TKC013753
|
P03372 |
Estrogen receptor |
None |
8913 |
nM |
Potency |
TKC019072
|
P03372 |
Estrogen receptor |
None |
78 |
% |
Activity |
TKC022931
|
P03372 |
Estrogen receptor |
None |
1995 |
nM |
Potency |
TKC022961
|
P03372 |
Estrogen receptor |
None |
54 |
% |
Activity |
TKC028029
|
P03372 |
Estrogen receptor |
None |
0 |
% |
Activity |
TKC028034
|
P03372 |
Estrogen receptor |
None |
<0 |
% |
Activity |
TKC028037
|
P03372 |
Estrogen receptor |
None |
1 |
% |
Activity |
TKC028038
|
P03372 |
Estrogen receptor |
None |
<0 |
% |
Activity |
TKC028041
|
P03372 |
Estrogen receptor |
None |
<0 |
% |
Activity |
TKC034016
|
P03372 |
Estrogen receptor |
None |
51 |
% |
Activity |
TKC034337
|
P03372 |
Estrogen receptor |
None |
2800000 |
nM |
IC50 |
TKC034640
|
P03372 |
Estrogen receptor |
None |
>1000000 |
nM |
Ki |
TKC035208
|
P03372 |
Estrogen receptor |
None |
39 |
% |
Activity |
TKC035272
|
P03372 |
Estrogen receptor |
None |
2551 |
nM |
IC50 |
TKC035462
|
P03372 |
Estrogen receptor |
None |
42 |
% |
Activity |
TKC066169
|
P03372 |
Estrogen receptor |
None |
39811 |
nM |
Potency |
TKC075769
|
P03372 |
Estrogen receptor |
None |
251 |
nM |
Potency |
TKC079320
|
P03372 |
Estrogen receptor |
None |
<0 |
% |
Activity |
TKC079321
|
P03372 |
Estrogen receptor |
None |
<0 |
% |
Activity |
TKC087664
|
P03372 |
Estrogen receptor |
None |
3162 |
nM |
Potency |
TKC087988
|
P03372 |
Estrogen receptor |
None |
631 |
nM |
Potency |
TKC087991
|
P03372 |
Estrogen receptor |
None |
4467 |
nM |
Potency |
TKC092297
|
P03372 |
Estrogen receptor |
None |
15849 |
nM |
Potency |
TKC092348
|
P03372 |
Estrogen receptor |
None |
8913 |
nM |
Potency |
TKC096012
|
P03372 |
Estrogen receptor |
None |
126 |
nM |
Potency |
TKC100644
|
P03372 |
Estrogen receptor |
None |
31623 |
nM |
Potency |
TKC101365
|
P03372 |
Estrogen receptor |
None |
12570 |
nM |
EC50 |
TKC102448
|
P03372 |
Estrogen receptor |
None |
2550 |
nM |
EC50 |
TKC107086
|
P03372 |
Estrogen receptor |
None |
8913 |
nM |
Potency |
TKC107735
|
P03372 |
Estrogen receptor |
None |
50119 |
nM |
Potency |
TKC111727
|
P03372 |
Estrogen receptor |
None |
0 |
nM |
Ki |
TKC111738
|
P03372 |
Estrogen receptor |
None |
1 |
nM |
EC50 |
TKC111738
|
P03372 |
Estrogen receptor |
None |
166 |
nM |
IC50 |
TKC111738
|
P03372 |
Estrogen receptor |
None |
210 |
nM |
IC50 |
TKC111738
|
P03372 |
Estrogen receptor |
None |
96 |
nM |
IC50 |
TKC112923
|
P03372 |
Estrogen receptor |
None |
26 |
nM |
EC50 |
TKC115268
|
P03372 |
Estrogen receptor |
None |
15849 |
nM |
Potency |
TKC129821
|
P03372 |
Estrogen receptor |
None |
70 |
% |
Activity |
TKC151345
|
P03372 |
Estrogen receptor |
None |
35 |
% |
Activity |
TKC151713
|
P03372 |
Estrogen receptor |
None |
40 |
% |
Activity |
TKC151765
|
P03372 |
Estrogen receptor |
None |
81 |
% |
Activity |
TKC206549
|
P03372 |
Estrogen receptor |
None |
3548 |
nM |
Potency |
TKC206608
|
P03372 |
Estrogen receptor |
None |
8170 |
nM |
EC50 |
TKC206652
|
P03372 |
Estrogen receptor |
None |
112 |
nM |
Potency |
TKC206725
|
P03372 |
Estrogen receptor |
None |
8 |
nM |
Ki |
TKC206726
|
P03372 |
Estrogen receptor |
None |
72 |
nM |
EC50 |
TKC206759
|
P03372 |
Estrogen receptor |
None |
>10000 |
nM |
IC50 |
TKC206759
|
P03372 |
Estrogen receptor |
None |
>10000 |
nM |
IC50 |
TKC206760
|
P03372 |
Estrogen receptor |
None |
25119 |
nM |
Potency |
TKC206764
|
P03372 |
Estrogen receptor |
None |
0 |
% |
RBA |
TKC206770
|
P03372 |
Estrogen receptor |
None |
5012 |
nM |
Potency |
TKC206779
|
P03372 |
Estrogen receptor |
None |
6310 |
nM |
Potency |
TKC206812
|
P03372 |
Estrogen receptor |
None |
62000 |
nM |
IC50 |
TKC206812
|
P03372 |
Estrogen receptor |
None |
39811 |
nM |
Potency |
TKC206816
|
P03372 |
Estrogen receptor |
None |
>1000 |
nM |
IC50 |
TKC206816
|
P03372 |
Estrogen receptor |
None |
>1000 |
nM |
IC50 |
TKC008187
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
30200 |
nM |
IC50 |
TKC023515
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
53 |
% |
Inhibition |
TKC025574
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
52 |
% |
Inhibition |
TKC026893
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
21 |
% |
Inhibition |
TKC026895
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
61 |
% |
Inhibition |
TKC057019
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
22300 |
nM |
IC50 |
TKC100777
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
30 |
% |
Inhibition |
TKC101031
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
1500 |
nM |
IC50 |
TKC101538
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
39 |
% |
Inhibition |
TKC101847
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
1000 |
nM |
IC50 |
TKC103703
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
40 |
% |
Inhibition |
TKC137314
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
8400 |
nM |
IC50 |
TKC138471
|
P04035 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase |
None |
21700 |
nM |
IC50 |
TKC057132
|
P10613 |
Lanosterol 14-alpha demethylase |
None |
7400 |
nM |
Km |
TKC206812
|
P10827 |
Thyroid hormone receptor alpha |
None |
>100000 |
nM |
EC50 |
TKC005454
|
P10828 |
Thyroid hormone receptor beta |
None |
50119 |
nM |
Potency |
TKC017379
|
P10828 |
Thyroid hormone receptor beta |
None |
35481 |
nM |
Potency |
TKC019353
|
P10828 |
Thyroid hormone receptor beta |
None |
4467 |
nM |
Potency |
TKC020732
|
P10828 |
Thyroid hormone receptor beta |
None |
794328 |
nM |
Potency |
TKC026870
|
P10828 |
Thyroid hormone receptor beta |
None |
2239 |
nM |
Potency |
TKC034632
|
P10828 |
Thyroid hormone receptor beta |
None |
63096 |
nM |
Potency |
TKC035272
|
P10828 |
Thyroid hormone receptor beta |
None |
22387 |
nM |
Potency |
TKC042351
|
P10828 |
Thyroid hormone receptor beta |
None |
2512 |
nM |
Potency |
TKC075769
|
P10828 |
Thyroid hormone receptor beta |
None |
126 |
nM |
Potency |
TKC079004
|
P10828 |
Thyroid hormone receptor beta |
None |
89125 |
nM |
Potency |
TKC079006
|
P10828 |
Thyroid hormone receptor beta |
None |
89125 |
nM |
Potency |
TKC087988
|
P10828 |
Thyroid hormone receptor beta |
None |
22387 |
nM |
Potency |
TKC088230
|
P10828 |
Thyroid hormone receptor beta |
None |
25119 |
nM |
Potency |
TKC092297
|
P10828 |
Thyroid hormone receptor beta |
None |
39811 |
nM |
Potency |
TKC096012
|
P10828 |
Thyroid hormone receptor beta |
None |
3 |
nM |
Potency |
TKC102144
|
P10828 |
Thyroid hormone receptor beta |
None |
4 |
nM |
Potency |
TKC102407
|
P10828 |
Thyroid hormone receptor beta |
None |
1 |
nM |
Potency |
TKC107086
|
P10828 |
Thyroid hormone receptor beta |
None |
8913 |
nM |
Potency |
TKC107515
|
P10828 |
Thyroid hormone receptor beta |
None |
25119 |
nM |
Potency |
TKC108536
|
P10828 |
Thyroid hormone receptor beta |
None |
44668 |
nM |
Potency |
TKC109617
|
P10828 |
Thyroid hormone receptor beta |
None |
36 |
nM |
Potency |
TKC113161
|
P10828 |
Thyroid hormone receptor beta |
None |
18 |
nM |
Potency |
TKC113663
|
P10828 |
Thyroid hormone receptor beta |
None |
3 |
nM |
Potency |
TKC115268
|
P10828 |
Thyroid hormone receptor beta |
None |
44668 |
nM |
Potency |
TKC118419
|
P10828 |
Thyroid hormone receptor beta |
None |
31623 |
nM |
Potency |
TKC120161
|
P10828 |
Thyroid hormone receptor beta |
None |
36 |
nM |
Potency |
TKC136852
|
P10828 |
Thyroid hormone receptor beta |
None |
501 |
nM |
Potency |
TKC151274
|
P10828 |
Thyroid hormone receptor beta |
None |
18 |
nM |
Potency |
TKC205928
|
P10828 |
Thyroid hormone receptor beta |
None |
1000000 |
nM |
Potency |
TKC206348
|
P10828 |
Thyroid hormone receptor beta |
None |
2818 |
nM |
Potency |
TKC206652
|
P10828 |
Thyroid hormone receptor beta |
None |
71 |
nM |
Potency |
TKC206688
|
P10828 |
Thyroid hormone receptor beta |
None |
35481 |
nM |
Potency |
TKC206760
|
P10828 |
Thyroid hormone receptor beta |
None |
22387 |
nM |
Potency |
TKC206812
|
P10828 |
Thyroid hormone receptor beta |
None |
44668 |
nM |
Potency |
TKC206816
|
P10828 |
Thyroid hormone receptor beta |
None |
44668 |
nM |
Potency |
TKC206884
|
P10828 |
Thyroid hormone receptor beta |
None |
1585 |
nM |
Potency |
TKC002411
|
P11597 |
Cholesteryl ester transfer protein |
None |
196000 |
nM |
IC50 |
TKC026245
|
P11597 |
Cholesteryl ester transfer protein |
None |
25000 |
nM |
IC50 |
TKC026309
|
P11597 |
Cholesteryl ester transfer protein |
None |
6000 |
nM |
IC50 |
TKC026600
|
P11597 |
Cholesteryl ester transfer protein |
None |
100000 |
nM |
IC50 |
TKC027200
|
P11597 |
Cholesteryl ester transfer protein |
None |
5000 |
nM |
IC50 |
TKC027200
|
P11597 |
Cholesteryl ester transfer protein |
None |
5200 |
nM |
IC50 |
TKC027201
|
P11597 |
Cholesteryl ester transfer protein |
None |
1000 |
nM |
IC50 |
TKC027201
|
P11597 |
Cholesteryl ester transfer protein |
None |
5200 |
nM |
IC50 |
TKC056482
|
P11597 |
Cholesteryl ester transfer protein |
None |
46600 |
nM |
IC50 |
TKC077689
|
P11597 |
Cholesteryl ester transfer protein |
None |
10 |
% |
Inhibition |
TKC094496
|
P11597 |
Cholesteryl ester transfer protein |
None |
46000 |
nM |
IC50 |
TKC097288
|
P11597 |
Cholesteryl ester transfer protein |
None |
600 |
nM |
IC50 |
TKC106450
|
P11597 |
Cholesteryl ester transfer protein |
None |
5200 |
nM |
IC50 |
TKC123088
|
P11597 |
Cholesteryl ester transfer protein |
None |
31 |
% |
Inhibition |
TKC005454
|
P23141 |
Liver carboxylesterase 1 |
None |
544 |
nM |
Ki |
TKC012269
|
P23141 |
Liver carboxylesterase 1 |
None |
2530 |
nM |
Ki |
TKC014568
|
P23141 |
Liver carboxylesterase 1 |
None |
26250 |
nM |
Ki |
TKC088678
|
P23141 |
Liver carboxylesterase 1 |
None |
20970 |
nM |
IC50 |
TKC088715
|
P23141 |
Liver carboxylesterase 1 |
None |
49860 |
nM |
IC50 |
TKC101270
|
P23141 |
Liver carboxylesterase 1 |
None |
23610 |
nM |
IC50 |
TKC103069
|
P23141 |
Liver carboxylesterase 1 |
None |
49860 |
nM |
IC50 |
TKC107319
|
P23141 |
Liver carboxylesterase 1 |
None |
>100000 |
nM |
Ki |
TKC141401
|
P23141 |
Liver carboxylesterase 1 |
None |
10530 |
nM |
IC50 |
TKC141510
|
P23141 |
Liver carboxylesterase 1 |
None |
22360 |
nM |
IC50 |
TKC151739
|
P23141 |
Liver carboxylesterase 1 |
None |
>100000 |
nM |
IC50 |
TKC000611
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
40000 |
nM |
IC50 |
TKC001618
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
34000 |
nM |
IC50 |
TKC009896
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
791100 |
nM |
IC50 |
TKC019819
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
48 |
% |
Inhibition |
TKC019859
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
54 |
% |
Inhibition |
TKC020491
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
4000 |
nM |
IC50 |
TKC020796
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
30 |
% |
Inhibition |
TKC021940
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
40 |
% |
Inhibition |
TKC022833
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
43 |
% |
Inhibition |
TKC022834
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
43 |
% |
Inhibition |
TKC022961
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
44 |
% |
Inhibition |
TKC024587
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
3300 |
nM |
IC50 |
TKC024587
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
3300 |
nM |
IC50 |
TKC031258
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
3600 |
nM |
IC50 |
TKC034201
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>200000 |
nM |
IC50 |
TKC034358
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
39000 |
nM |
IC50 |
TKC034359
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
39000 |
nM |
IC50 |
TKC036372
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
14000 |
nM |
IC50 |
TKC037595
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
36000 |
nM |
IC50 |
TKC043613
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
43000 |
nM |
IC50 |
TKC049750
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC049818
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
44 |
ug |
IC50 |
TKC054011
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
8800 |
nM |
IC50 |
TKC054031
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC054081
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC054090
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
7500 |
nM |
IC50 |
TKC054099
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
8800 |
nM |
IC50 |
TKC054100
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
8900 |
nM |
IC50 |
TKC054101
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
7600 |
nM |
IC50 |
TKC054240
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
7800 |
nM |
IC50 |
TKC054241
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
6300 |
nM |
IC50 |
TKC056482
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
210000 |
nM |
IC50 |
TKC060184
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
8300 |
nM |
IC50 |
TKC060216
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC060284
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC060302
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC060303
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
7800 |
nM |
IC50 |
TKC060304
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
8000 |
nM |
IC50 |
TKC060399
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC060602
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
5900 |
nM |
IC50 |
TKC066954
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
38 |
% |
Inhibition |
TKC068533
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
28000 |
nM |
IC50 |
TKC071010
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC077689
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
380000 |
nM |
IC50 |
TKC077689
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
380000 |
nM |
IC50 |
TKC095276
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
48 |
% |
Inhibition |
TKC113936
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
65 |
% |
Inhibition |
TKC122543
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
35 |
% |
Inhibition |
TKC130084
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
39 |
% |
Inhibition |
TKC130119
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
33 |
% |
Inhibition |
TKC130577
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
<43 |
% |
Inhibition |
TKC130901
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
36 |
% |
Inhibition |
TKC133309
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>200000 |
nM |
IC50 |
TKC133517
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
1300 |
nM |
IC50 |
TKC133656
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>200000 |
nM |
IC50 |
TKC134278
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>200000 |
nM |
IC50 |
TKC139036
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC140627
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC141365
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC143641
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
>50000 |
nM |
IC50 |
TKC151113
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
116400 |
nM |
IC50 |
TKC151284
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
51 |
% |
Inhibition |
TKC151765
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
48 |
% |
Inhibition |
TKC151792
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
14000 |
nM |
IC50 |
TKC172853
|
P23219 |
Prostaglandin G/H synthase 1 |
None |
43700 |
nM |
IC50 |
TKC012378
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
56 |
% |
Inhibition |
TKC036177
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
13 |
nM |
IC50 |
TKC036177
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
13 |
nM |
IC50 |
TKC047464
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
<50 |
% |
Inhibition |
TKC049301
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
22 |
% |
Inhibition |
TKC049302
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
6 |
% |
Inhibition |
TKC049559
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
11400 |
nM |
IC50 |
TKC049666
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
3800 |
nM |
IC50 |
TKC049832
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
395 |
nM |
IC50 |
TKC049833
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
34 |
nM |
IC50 |
TKC050879
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
>10000 |
nM |
IC50 |
TKC051029
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
46 |
% |
Inhibition |
TKC051154
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
63 |
% |
Inhibition |
TKC052452
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
>10000 |
nM |
IC50 |
TKC053100
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
3200 |
nM |
IC50 |
TKC053930
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
6 |
nM |
IC50 |
TKC055403
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
1400 |
nM |
IC50 |
TKC055404
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
4100 |
nM |
IC50 |
TKC055890
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
105 |
nM |
IC50 |
TKC056332
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
>10000 |
nM |
IC50 |
TKC056482
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
1900 |
nM |
IC50 |
TKC057835
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
2300 |
nM |
IC50 |
TKC063150
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
<50 |
% |
Inhibition |
TKC063649
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
72 |
nM |
IC50 |
TKC064069
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
76 |
nM |
IC50 |
TKC064070
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
195 |
nM |
IC50 |
TKC064071
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
15 |
nM |
IC50 |
TKC064939
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
45 |
% |
Inhibition |
TKC064940
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
3740 |
nM |
IC50 |
TKC075891
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
6 |
nM |
IC50 |
TKC076051
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
>35 |
% |
Inhibition |
TKC077375
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
97 |
% |
Inhibition |
TKC079733
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
82 |
% |
Inhibition |
TKC080267
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
40 |
% |
Inhibition |
TKC088620
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
62 |
nM |
Ki |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
9 |
nM |
IC50 |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
29 |
nM |
IC50 |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
13 |
nM |
IC50 |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
778 |
nM |
IC50 |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
778 |
nM |
IC50 |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
11.78 |
nM |
IC50 |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
11 |
nM |
IC50 |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
29 |
nM |
IC50 |
TKC088678
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
8.8 |
nM |
IC50 |
TKC088715
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
800 |
nM |
IC50 |
TKC088715
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
7138 |
nM |
IC50 |
TKC088715
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
7100 |
nM |
IC50 |
TKC088961
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
929 |
nM |
IC50 |
TKC088962
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
825 |
nM |
IC50 |
TKC088963
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
626 |
nM |
IC50 |
TKC088981
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
504 |
nM |
IC50 |
TKC102290
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
>10000 |
nM |
IC50 |
TKC103069
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
800 |
nM |
IC50 |
TKC104256
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
2060 |
nM |
IC50 |
TKC104829
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
20 |
% |
Inhibition |
TKC105165
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
4 |
% |
Activity |
TKC106140
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
17 |
% |
Inhibition |
TKC107137
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
910 |
nM |
IC50 |
TKC138609
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
<50 |
% |
Inhibition |
TKC139322
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
810 |
nM |
IC50 |
TKC139355
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
5200 |
nM |
IC50 |
TKC139366
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
52 |
% |
Inhibition |
TKC141002
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
<50 |
% |
Inhibition |
TKC145231
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
<50 |
% |
Inhibition |
TKC145651
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
9400 |
nM |
IC50 |
TKC145901
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
1350 |
nM |
IC50 |
TKC151633
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
1236 |
nM |
IC50 |
TKC151739
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
619 |
nM |
IC50 |
TKC151798
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
1417 |
nM |
IC50 |
TKC205472
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
>9900 |
nM |
IC50 |
TKC205869
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
>1900 |
nM |
IC50 |
TKC206764
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
81 |
% |
Inhibition |
TKC207256
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
>353700 |
nM |
Ki |
TKC207257
|
P28845 |
Corticosteroid 11-beta-dehydrogenase isozyme 1 |
None |
13500 |
nM |
Ki |
TKC008359
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC010020
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
61 |
% |
Inhibition |
TKC010022
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
55 |
% |
Inhibition |
TKC010023
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
57 |
% |
Inhibition |
TKC010024
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
42 |
% |
Inhibition |
TKC010025
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
78 |
% |
Inhibition |
TKC010026
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
17 |
% |
Inhibition |
TKC011599
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
64 |
% |
Inhibition |
TKC012919
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC012941
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
8500 |
nM |
IC50 |
TKC012956
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
2200 |
nM |
IC50 |
TKC012962
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC015443
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC015459
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
2200 |
nM |
IC50 |
TKC015537
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
0 |
% |
Inhibition |
TKC016794
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
40 |
nM |
IC50 |
TKC019436
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC019466
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC019819
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
35 |
% |
Inhibition |
TKC019859
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<33 |
% |
Inhibition |
TKC020479
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC020796
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC021940
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC022833
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC022834
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC022961
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC026245
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
2300 |
nM |
IC50 |
TKC027200
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
700 |
nM |
IC50 |
TKC028143
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Inhibition |
TKC031202
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
3800 |
nM |
IC50 |
TKC031223
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
45 |
% |
Inhibition |
TKC032234
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
400 |
nM |
IC50 |
TKC035208
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
7 |
uM |
IC60 |
TKC037534
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
97 |
% |
Inhibition |
TKC038330
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
2900 |
nM |
IC50 |
TKC041884
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
18000 |
nM |
IC50 |
TKC043993
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
98 |
% |
Inhibition |
TKC045188
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
98 |
% |
Inhibition |
TKC048282
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
370 |
nM |
IC50 |
TKC049750
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC049818
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
5 |
ug |
IC50 |
TKC051154
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>61 |
% |
Activity |
TKC054011
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
9000 |
nM |
IC50 |
TKC054031
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC054081
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC054090
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
8900 |
nM |
IC50 |
TKC054099
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
7800 |
nM |
IC50 |
TKC054100
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
7900 |
nM |
IC50 |
TKC054101
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
8800 |
nM |
IC50 |
TKC054240
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
6700 |
nM |
IC50 |
TKC054241
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
6100 |
nM |
IC50 |
TKC056482
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
40000 |
nM |
IC50 |
TKC056482
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
86000 |
nM |
IC50 |
TKC056482
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
130000 |
nM |
IC50 |
TKC057308
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC058811
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>85 |
% |
Activity |
TKC058812
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>78 |
% |
Activity |
TKC060184
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
8500 |
nM |
IC50 |
TKC060216
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC060284
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC060302
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC060303
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
7200 |
nM |
IC50 |
TKC060304
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
7600 |
nM |
IC50 |
TKC060399
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC060602
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
6700 |
nM |
IC50 |
TKC061939
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>10000 |
nM |
IC50 |
TKC061968
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>10000 |
nM |
IC50 |
TKC061969
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>10000 |
nM |
IC50 |
TKC064374
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>73 |
% |
Activity |
TKC064407
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>78 |
% |
Activity |
TKC065375
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>70 |
% |
Activity |
TKC066954
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC070952
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>100000 |
nM |
IC50 |
TKC071010
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC071640
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC076350
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC077689
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
40000 |
nM |
IC50 |
TKC077689
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
295000 |
nM |
IC50 |
TKC077689
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
295000 |
nM |
IC50 |
TKC077689
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
87000 |
nM |
IC50 |
TKC077703
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC078194
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>74 |
% |
Activity |
TKC085168
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<60 |
% |
Inhibition |
TKC088678
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>72 |
% |
Activity |
TKC095276
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC095567
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>10000 |
nM |
IC50 |
TKC110247
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>10 |
ug.mL-1 |
IC50 |
TKC113936
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
60 |
% |
Inhibition |
TKC122543
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
30 |
% |
Inhibition |
TKC123028
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>72 |
% |
Activity |
TKC129152
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>100000 |
nM |
IC50 |
TKC130084
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
37 |
% |
Inhibition |
TKC130119
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC130223
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC130577
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC130901
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC135264
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
400 |
nM |
IC50 |
TKC135559
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
4600 |
nM |
IC50 |
TKC139036
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC139322
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>82 |
% |
Activity |
TKC139366
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
40000 |
nM |
IC50 |
TKC140627
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC141365
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC141401
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>75 |
% |
Activity |
TKC141499
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>87 |
% |
Activity |
TKC141601
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
10000 |
nM |
IC50 |
TKC141602
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
10000 |
nM |
IC50 |
TKC141622
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
10000 |
nM |
IC50 |
TKC141805
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
40000 |
nM |
IC50 |
TKC142150
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
450000 |
nM |
IC50 |
TKC142203
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>10000 |
nM |
IC50 |
TKC142208
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>10000 |
nM |
IC50 |
TKC142849
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>69 |
% |
Activity |
TKC142897
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC142922
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC143527
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
97 |
% |
Inhibition |
TKC143539
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC143641
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC145295
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
22 |
% |
Inhibition |
TKC145848
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC145932
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC145968
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>94 |
% |
Activity |
TKC146116
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>5.0e+4 |
nM |
IC50 |
TKC146774
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>78 |
% |
Activity |
TKC146857
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
600 |
nM |
IC50 |
TKC149251
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
1100 |
nM |
IC50 |
TKC149759
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
100 |
% |
Activity |
TKC149924
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
800 |
nM |
IC50 |
TKC149926
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
800 |
nM |
IC50 |
TKC150635
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
10000 |
nM |
IC50 |
TKC150706
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>76 |
% |
Activity |
TKC150907
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC151280
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC151284
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
33 |
% |
Inhibition |
TKC151765
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC152742
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC152813
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
10000 |
nM |
IC50 |
TKC156345
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
25 |
% |
Inhibition |
TKC156572
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
10000 |
nM |
IC50 |
TKC156716
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
2200 |
nM |
IC50 |
TKC170277
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
>50000 |
nM |
IC50 |
TKC172853
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
4700 |
nM |
IC50 |
TKC174442
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
10000 |
nM |
IC50 |
TKC205509
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
540000 |
nM |
IC50 |
TKC205699
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC205700
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
<30 |
% |
Inhibition |
TKC206319
|
P35354 |
Prostaglandin G/H synthase 2 |
None |
99 |
% |
Inhibition |
TKC005728
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
>100000 |
nM |
EC50 |
TKC005729
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
16700 |
nM |
EC50 |
TKC013753
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
2818 |
nM |
Potency |
TKC021262
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
21700 |
nM |
EC50 |
TKC035272
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
7943 |
nM |
Potency |
TKC066169
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
28184 |
nM |
Potency |
TKC075769
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
316 |
nM |
Potency |
TKC079000
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
50119 |
nM |
Potency |
TKC087664
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
44668 |
nM |
Potency |
TKC087991
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
3162 |
nM |
Potency |
TKC088230
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
44668 |
nM |
Potency |
TKC092297
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
15849 |
nM |
Potency |
TKC096012
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
316 |
nM |
Potency |
TKC100644
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
44668 |
nM |
Potency |
TKC102407
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
50119 |
nM |
Potency |
TKC107086
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
28184 |
nM |
Potency |
TKC107735
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
39811 |
nM |
Potency |
TKC108536
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
44668 |
nM |
Potency |
TKC110634
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
6400 |
nM |
EC50 |
TKC110635
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
8200 |
nM |
EC50 |
TKC111200
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
22300 |
nM |
EC50 |
TKC111271
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
>50000 |
nM |
EC50 |
TKC111272
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
18700 |
nM |
EC50 |
TKC111273
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
>50000 |
nM |
EC50 |
TKC111274
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
20600 |
nM |
EC50 |
TKC111276
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
>50000 |
nM |
EC50 |
TKC111284
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
>50000 |
nM |
EC50 |
TKC111466
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
>50000 |
nM |
EC50 |
TKC115268
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
44668 |
nM |
Potency |
TKC170559
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
1000 |
nM |
EC50 |
TKC206549
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
126 |
nM |
Potency |
TKC206652
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
316 |
nM |
Potency |
TKC206672
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
31623 |
nM |
Potency |
TKC206759
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
12589 |
nM |
Potency |
TKC206760
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
17783 |
nM |
Potency |
TKC206812
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
27000 |
nM |
IC50 |
TKC206812
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
50119 |
nM |
Potency |
TKC206816
|
P37231 |
Peroxisome proliferator-activated receptor gamma |
None |
39811 |
nM |
Potency |
TKC073907
|
P37268 |
Squalene synthase |
None |
2300 |
nM |
Km |
TKC122582
|
P37268 |
Squalene synthase |
None |
2300 |
nM |
Km |
TKC147153
|
P37268 |
Squalene synthase |
None |
2300 |
nM |
Km |
TKC038192
|
Q02127 |
Dihydroorotate dehydrogenase |
None |
3 |
% |
Inhibition |
TKC039868
|
Q02127 |
Dihydroorotate dehydrogenase |
None |
0 |
% |
Inhibition |
TKC043742
|
Q02127 |
Dihydroorotate dehydrogenase |
None |
0 |
% |
Inhibition |
TKC079733
|
Q02127 |
Dihydroorotate dehydrogenase |
None |
28 |
% |
Inhibition |
TKC136181
|
Q02127 |
Dihydroorotate dehydrogenase |
None |
12 |
% |
Inhibition |
TKC020732
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
1258925 |
nM |
Potency |
TKC021262
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
48500 |
nM |
EC50 |
TKC021321
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
50119 |
nM |
Potency |
TKC034760
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
50119 |
nM |
Potency |
TKC035272
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
10000 |
nM |
Potency |
TKC038473
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
14125 |
nM |
Potency |
TKC066169
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
15849 |
nM |
Potency |
TKC074866
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
1 |
nM |
Potency |
TKC075769
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
141 |
nM |
Potency |
TKC079001
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
50119 |
nM |
Potency |
TKC087664
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
50119 |
nM |
Potency |
TKC092297
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
44668 |
nM |
Potency |
TKC096012
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
44668 |
nM |
Potency |
TKC100644
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
15849 |
nM |
Potency |
TKC102407
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
22387 |
nM |
Potency |
TKC107086
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
39811 |
nM |
Potency |
TKC107735
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
12589 |
nM |
Potency |
TKC108536
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
2 |
nM |
Potency |
TKC110634
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
100 |
% |
Activity |
TKC110635
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
100 |
% |
Activity |
TKC115268
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
39811 |
nM |
Potency |
TKC122884
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
79433 |
nM |
Potency |
TKC136411
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
31623 |
nM |
Potency |
TKC206652
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
251 |
nM |
Potency |
TKC206672
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
17783 |
nM |
Potency |
TKC206759
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
50119 |
nM |
Potency |
TKC206760
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
35481 |
nM |
Potency |
TKC206770
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
31623 |
nM |
Potency |
TKC206812
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
22387 |
nM |
Potency |
TKC206816
|
Q03181 |
Peroxisome proliferator-activated receptor delta |
None |
25119 |
nM |
Potency |
TKC021262
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
19500 |
nM |
EC50 |
TKC021666
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
28 |
% |
Activity |
TKC021674
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
25 |
% |
Activity |
TKC035272
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
15849 |
nM |
Potency |
TKC056482
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
259 |
% |
Activity |
TKC057132
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
12589 |
nM |
Potency |
TKC088526
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
12 |
% |
Activity |
TKC100644
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
8913 |
nM |
Potency |
TKC108536
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
50119 |
nM |
Potency |
TKC110634
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
309 |
% |
Activity |
TKC110635
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
289 |
% |
Activity |
TKC170559
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
1000 |
nM |
EC50 |
TKC171329
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
184 |
nM |
EC50 |
TKC206812
|
Q07869 |
Peroxisome proliferator-activated receptor alpha |
None |
>20000 |
nM |
IC50 |
TKC106240
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
3300 |
nM |
Ki |
TKC106250
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
75000 |
nM |
Ki |
TKC109619
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
75000 |
nM |
Ki |
TKC109621
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
4100 |
nM |
Km |
TKC109622
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
28000 |
nM |
Ki |
TKC109625
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
2000 |
nM |
Km |
TKC206670
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
5700 |
nM |
Km |
TKC206671
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
6100 |
nM |
Ki |
TKC206672
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
6300 |
nM |
Ki |
TKC206849
|
Q12908 |
Ileal sodium/bile acid cotransporter |
None |
41500 |
nM |
Ki |
TKC023246
|
Q92731 |
Estrogen receptor beta |
None |
>10000 |
nM |
IC50 |
TKC028029
|
Q92731 |
Estrogen receptor beta |
None |
<1 |
% |
Activity |
TKC028037
|
Q92731 |
Estrogen receptor beta |
None |
10 |
% |
Activity |
TKC035272
|
Q92731 |
Estrogen receptor beta |
None |
>50000 |
nM |
IC50 |
TKC100932
|
Q92731 |
Estrogen receptor beta |
None |
25300 |
nM |
EC50 |
TKC101365
|
Q92731 |
Estrogen receptor beta |
None |
17690 |
nM |
EC50 |
TKC102448
|
Q92731 |
Estrogen receptor beta |
None |
4680 |
nM |
EC50 |
TKC106878
|
Q92731 |
Estrogen receptor beta |
None |
>10000 |
nM |
IC50 |
TKC110673
|
Q92731 |
Estrogen receptor beta |
None |
2.78E+11 |
M-1 |
Ka |
TKC111721
|
Q92731 |
Estrogen receptor beta |
None |
1520000000 |
M-1 |
Ka |
TKC111727
|
Q92731 |
Estrogen receptor beta |
None |
614000000 |
M-1 |
Ka |
TKC111727
|
Q92731 |
Estrogen receptor beta |
None |
0 |
nM |
EC50 |
TKC111738
|
Q92731 |
Estrogen receptor beta |
None |
2 |
nM |
EC50 |
TKC111738
|
Q92731 |
Estrogen receptor beta |
None |
4 |
% |
RSA |
TKC111738
|
Q92731 |
Estrogen receptor beta |
None |
26 |
nM |
IC50 |
TKC111738
|
Q92731 |
Estrogen receptor beta |
None |
540 |
nM |
IC50 |
TKC111738
|
Q92731 |
Estrogen receptor beta |
None |
8 |
nM |
EC50 |
TKC112923
|
Q92731 |
Estrogen receptor beta |
None |
6 |
nM |
EC50 |
TKC206608
|
Q92731 |
Estrogen receptor beta |
None |
4280 |
nM |
EC50 |
TKC206725
|
Q92731 |
Estrogen receptor beta |
None |
24 |
nM |
Ki |
TKC206726
|
Q92731 |
Estrogen receptor beta |
None |
11 |
nM |
EC50 |
TKC206759
|
Q92731 |
Estrogen receptor beta |
None |
>10000 |
nM |
IC50 |
TKC206759
|
Q92731 |
Estrogen receptor beta |
None |
>10000 |
nM |
IC50 |
TKC206764
|
Q92731 |
Estrogen receptor beta |
None |
1 |
% |
RBA |
TKC206765
|
Q92731 |
Estrogen receptor beta |
None |
18000000 |
M-1 |
Ka |
TKC206769
|
Q92731 |
Estrogen receptor beta |
None |
27000000 |
M-1 |
Ka |
TKC206812
|
Q92731 |
Estrogen receptor beta |
None |
>5000 |
nM |
IC50 |
TKC206816
|
Q92731 |
Estrogen receptor beta |
None |
1000000 |
nM |
IC50 |
TKC013753
|
Q96RI1 |
Bile acid receptor |
None |
16 |
nM |
Potency |
TKC016414
|
Q96RI1 |
Bile acid receptor |
None |
9700 |
nM |
IC50 |
TKC016817
|
Q96RI1 |
Bile acid receptor |
None |
3900 |
nM |
IC50 |
TKC017639
|
Q96RI1 |
Bile acid receptor |
None |
1 |
% |
Activity |
TKC019374
|
Q96RI1 |
Bile acid receptor |
None |
4 |
nM |
Potency |
TKC021321
|
Q96RI1 |
Bile acid receptor |
None |
39811 |
nM |
Potency |
TKC021365
|
Q96RI1 |
Bile acid receptor |
None |
28184 |
nM |
Potency |
TKC021425
|
Q96RI1 |
Bile acid receptor |
None |
28184 |
nM |
Potency |
TKC022931
|
Q96RI1 |
Bile acid receptor |
None |
50119 |
nM |
Potency |
TKC026455
|
Q96RI1 |
Bile acid receptor |
None |
17000 |
nM |
IC50 |
TKC027095
|
Q96RI1 |
Bile acid receptor |
None |
1500 |
nM |
IC50 |
TKC027096
|
Q96RI1 |
Bile acid receptor |
None |
1500 |
nM |
IC50 |
TKC027225
|
Q96RI1 |
Bile acid receptor |
None |
5900 |
nM |
IC50 |
TKC035272
|
Q96RI1 |
Bile acid receptor |
None |
22387 |
nM |
Potency |
TKC045729
|
Q96RI1 |
Bile acid receptor |
None |
>100000 |
nM |
IC50 |
TKC045739
|
Q96RI1 |
Bile acid receptor |
None |
60400 |
nM |
IC50 |
TKC045844
|
Q96RI1 |
Bile acid receptor |
None |
24800 |
nM |
IC50 |
TKC045846
|
Q96RI1 |
Bile acid receptor |
None |
81100 |
nM |
IC50 |
TKC046058
|
Q96RI1 |
Bile acid receptor |
None |
31600 |
nM |
IC50 |
TKC046480
|
Q96RI1 |
Bile acid receptor |
None |
24000 |
nM |
EC50 |
TKC048922
|
Q96RI1 |
Bile acid receptor |
None |
8800 |
nM |
EC50 |
TKC048923
|
Q96RI1 |
Bile acid receptor |
None |
3570 |
nM |
EC50 |
TKC048938
|
Q96RI1 |
Bile acid receptor |
None |
15100 |
nM |
EC50 |
TKC048939
|
Q96RI1 |
Bile acid receptor |
None |
25290 |
nM |
EC50 |
TKC048940
|
Q96RI1 |
Bile acid receptor |
None |
4740 |
nM |
EC50 |
TKC048951
|
Q96RI1 |
Bile acid receptor |
None |
3260 |
nM |
EC50 |
TKC050873
|
Q96RI1 |
Bile acid receptor |
None |
3030 |
nM |
EC50 |
TKC050874
|
Q96RI1 |
Bile acid receptor |
None |
140 |
nM |
EC50 |
TKC050875
|
Q96RI1 |
Bile acid receptor |
None |
2400 |
nM |
EC50 |
TKC052230
|
Q96RI1 |
Bile acid receptor |
None |
13300 |
nM |
EC50 |
TKC052231
|
Q96RI1 |
Bile acid receptor |
None |
5660 |
nM |
EC50 |
TKC052444
|
Q96RI1 |
Bile acid receptor |
None |
10400 |
nM |
EC50 |
TKC053303
|
Q96RI1 |
Bile acid receptor |
None |
40740 |
nM |
EC50 |
TKC054499
|
Q96RI1 |
Bile acid receptor |
None |
20240 |
nM |
EC50 |
TKC055291
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC055602
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC056482
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC061474
|
Q96RI1 |
Bile acid receptor |
None |
4 |
nM |
Potency |
TKC062736
|
Q96RI1 |
Bile acid receptor |
None |
5640 |
nM |
EC50 |
TKC063162
|
Q96RI1 |
Bile acid receptor |
None |
29680 |
nM |
EC50 |
TKC063163
|
Q96RI1 |
Bile acid receptor |
None |
10160 |
nM |
EC50 |
TKC063164
|
Q96RI1 |
Bile acid receptor |
None |
15310 |
nM |
EC50 |
TKC063165
|
Q96RI1 |
Bile acid receptor |
None |
64890 |
nM |
EC50 |
TKC063168
|
Q96RI1 |
Bile acid receptor |
None |
940 |
nM |
EC50 |
TKC063169
|
Q96RI1 |
Bile acid receptor |
None |
8900 |
nM |
EC50 |
TKC064374
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC064856
|
Q96RI1 |
Bile acid receptor |
None |
6000 |
nM |
EC50 |
TKC064857
|
Q96RI1 |
Bile acid receptor |
None |
12140 |
nM |
EC50 |
TKC064858
|
Q96RI1 |
Bile acid receptor |
None |
15470 |
nM |
EC50 |
TKC064860
|
Q96RI1 |
Bile acid receptor |
None |
24090 |
nM |
EC50 |
TKC066169
|
Q96RI1 |
Bile acid receptor |
None |
35481 |
nM |
Potency |
TKC074296
|
Q96RI1 |
Bile acid receptor |
None |
20150 |
nM |
EC50 |
TKC074867
|
Q96RI1 |
Bile acid receptor |
None |
1 |
nM |
Potency |
TKC075769
|
Q96RI1 |
Bile acid receptor |
None |
18 |
nM |
Potency |
TKC077533
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC077595
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC077599
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC077601
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC077608
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC077609
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC077612
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC077626
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC077689
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082589
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082597
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082600
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082608
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082609
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082639
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082652
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082703
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082710
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082711
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC082712
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC086929
|
Q96RI1 |
Bile acid receptor |
None |
2 |
nM |
Potency |
TKC087988
|
Q96RI1 |
Bile acid receptor |
None |
7080 |
nM |
Potency |
TKC087991
|
Q96RI1 |
Bile acid receptor |
None |
70795 |
nM |
Potency |
TKC092297
|
Q96RI1 |
Bile acid receptor |
None |
39811 |
nM |
Potency |
TKC092348
|
Q96RI1 |
Bile acid receptor |
None |
25119 |
nM |
Potency |
TKC093375
|
Q96RI1 |
Bile acid receptor |
None |
9000 |
nM |
IC50 |
TKC096012
|
Q96RI1 |
Bile acid receptor |
None |
17783 |
nM |
Potency |
TKC100644
|
Q96RI1 |
Bile acid receptor |
None |
39811 |
nM |
Potency |
TKC102407
|
Q96RI1 |
Bile acid receptor |
None |
22387 |
nM |
Potency |
TKC103074
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC104925
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC105149
|
Q96RI1 |
Bile acid receptor |
None |
1 |
% |
Activity |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
3400 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
13000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
27000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
8300 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
>01000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
>10000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
>10000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
>10000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
18000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
18000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
18000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
13000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
21000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
10000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
8660 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
9000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
8660 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
8660 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
3500 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
11700 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
8660 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
13000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
6310 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
13000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
27000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
13000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
15000 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
8660 |
nM |
EC50 |
TKC106240
|
Q96RI1 |
Bile acid receptor |
None |
>10000 |
nM |
EC50 |
TKC106250
|
Q96RI1 |
Bile acid receptor |
None |
50000 |
nM |
EC50 |
TKC107086
|
Q96RI1 |
Bile acid receptor |
None |
28184 |
nM |
Potency |
TKC107735
|
Q96RI1 |
Bile acid receptor |
None |
15849 |
nM |
Potency |
TKC108191
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC108536
|
Q96RI1 |
Bile acid receptor |
None |
4 |
nM |
Potency |
TKC109619
|
Q96RI1 |
Bile acid receptor |
None |
50000 |
nM |
EC50 |
TKC109622
|
Q96RI1 |
Bile acid receptor |
None |
2 |
% |
Activity |
TKC111390
|
Q96RI1 |
Bile acid receptor |
None |
80 |
% |
Inhibition |
TKC112787
|
Q96RI1 |
Bile acid receptor |
None |
5 |
% |
Activity |
TKC113499
|
Q96RI1 |
Bile acid receptor |
None |
30 |
% |
Activity |
TKC114511
|
Q96RI1 |
Bile acid receptor |
None |
12000 |
nM |
EC50 |
TKC114511
|
Q96RI1 |
Bile acid receptor |
None |
100000 |
nM |
IC50 |
TKC114511
|
Q96RI1 |
Bile acid receptor |
None |
10000 |
nM |
IC50 |
TKC114511
|
Q96RI1 |
Bile acid receptor |
None |
12000 |
nM |
IC50 |
TKC114511
|
Q96RI1 |
Bile acid receptor |
None |
89360 |
nM |
IC50 |
TKC114511
|
Q96RI1 |
Bile acid receptor |
None |
4100 |
nM |
IC50 |
TKC114511
|
Q96RI1 |
Bile acid receptor |
None |
41000 |
nM |
IC50 |
TKC114511
|
Q96RI1 |
Bile acid receptor |
None |
44000 |
nM |
IC50 |
TKC115268
|
Q96RI1 |
Bile acid receptor |
None |
44668 |
nM |
Potency |
TKC117705
|
Q96RI1 |
Bile acid receptor |
None |
>9 |
% |
Efficacy |
TKC117716
|
Q96RI1 |
Bile acid receptor |
None |
33180 |
nM |
EC50 |
TKC117717
|
Q96RI1 |
Bile acid receptor |
None |
10230 |
nM |
EC50 |
TKC123088
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC131507
|
Q96RI1 |
Bile acid receptor |
None |
2500 |
nM |
IC50 |
TKC134780
|
Q96RI1 |
Bile acid receptor |
None |
35481 |
nM |
Potency |
TKC137135
|
Q96RI1 |
Bile acid receptor |
None |
2400 |
nM |
IC50 |
TKC137137
|
Q96RI1 |
Bile acid receptor |
None |
75000 |
nM |
IC50 |
TKC137142
|
Q96RI1 |
Bile acid receptor |
None |
24000 |
nM |
IC50 |
TKC137199
|
Q96RI1 |
Bile acid receptor |
None |
64500 |
nM |
IC50 |
TKC137200
|
Q96RI1 |
Bile acid receptor |
None |
25300 |
nM |
IC50 |
TKC141147
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC141164
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC141622
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC144889
|
Q96RI1 |
Bile acid receptor |
None |
189050 |
nM |
EC50 |
TKC145498
|
Q96RI1 |
Bile acid receptor |
None |
3360 |
nM |
EC50 |
TKC145848
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC145932
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC147336
|
Q96RI1 |
Bile acid receptor |
None |
34190 |
nM |
EC50 |
TKC150706
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC151412
|
Q96RI1 |
Bile acid receptor |
None |
110 |
nM |
EC50 |
TKC151556
|
Q96RI1 |
Bile acid receptor |
None |
2100 |
nM |
EC50 |
TKC152742
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC152765
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC152829
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC166596
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC167188
|
Q96RI1 |
Bile acid receptor |
None |
8100 |
nM |
IC50 |
TKC170602
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC170603
|
Q96RI1 |
Bile acid receptor |
None |
0 |
nM |
EC50 |
TKC203882
|
Q96RI1 |
Bile acid receptor |
None |
7320 |
nM |
EC50 |
TKC206249
|
Q96RI1 |
Bile acid receptor |
None |
12430 |
nM |
EC50 |
TKC206344
|
Q96RI1 |
Bile acid receptor |
None |
90 |
nM |
EC50 |
TKC206652
|
Q96RI1 |
Bile acid receptor |
None |
447 |
nM |
Potency |
TKC206670
|
Q96RI1 |
Bile acid receptor |
None |
3000 |
nM |
EC50 |
TKC206671
|
Q96RI1 |
Bile acid receptor |
None |
3000 |
nM |
EC50 |
TKC206672
|
Q96RI1 |
Bile acid receptor |
None |
45000 |
nM |
EC50 |
TKC206688
|
Q96RI1 |
Bile acid receptor |
None |
28184 |
nM |
Potency |
TKC206759
|
Q96RI1 |
Bile acid receptor |
None |
22387 |
nM |
Potency |
TKC206760
|
Q96RI1 |
Bile acid receptor |
None |
100000 |
nM |
EC50 |
TKC206760
|
Q96RI1 |
Bile acid receptor |
None |
18 |
nM |
IC50 |
TKC206760
|
Q96RI1 |
Bile acid receptor |
None |
20000 |
nM |
EC50 |
TKC206760
|
Q96RI1 |
Bile acid receptor |
None |
6700 |
nM |
EC50 |
TKC206812
|
Q96RI1 |
Bile acid receptor |
None |
130 |
nM |
EC50 |
TKC206812
|
Q96RI1 |
Bile acid receptor |
None |
5000 |
nM |
Ki |
TKC206816
|
Q96RI1 |
Bile acid receptor |
None |
12589 |
nM |
Potency |
TKC206884
|
Q96RI1 |
Bile acid receptor |
None |
25119 |
nM |
Potency |
TKC206884
|
Q96RI1 |
Bile acid receptor |
None |
2 |
% |
Efficacy |
TKC206884
|
Q96RI1 |
Bile acid receptor |
None |
>100000 |
nM |
EC50 |
TKC206884
|
Q96RI1 |
Bile acid receptor |
None |
>100000 |
nM |
EC50 |
TKC206885
|
Q96RI1 |
Bile acid receptor |
None |
100000 |
nM |
EC50 |
TKC206927
|
Q96RI1 |
Bile acid receptor |
None |
520 |
nM |
EC50 |
TKC112754
|
Q9UHC9 |
NPC1-like intracellular cholesterol transporter 1 |
None |
>10000 |
nM |
EC50 |
TKC112813
|
Q9UHC9 |
NPC1-like intracellular cholesterol transporter 1 |
None |
3400 |
nM |
EC50 |
TKC112826
|
Q9UHC9 |
NPC1-like intracellular cholesterol transporter 1 |
None |
8700 |
nM |
EC50 |
TKC118895
|
Q9UHC9 |
NPC1-like intracellular cholesterol transporter 1 |
None |
1700 |
nM |
EC50 |
TKC206458
|
Q9UHC9 |
NPC1-like intracellular cholesterol transporter 1 |
None |
2900 |
nM |
EC50 |
TKC206915
|
Q9UHC9 |
NPC1-like intracellular cholesterol transporter 1 |
None |
3400 |
nM |
EC50 |