Basic Information

Terpenoid ID TKC016794
Chirality TKC096365
Cell line 0
Protein target 10
DiseaseNCIT 0
ORDO 0
ICD 42

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC016794 KB KB (HeLa derivative); HeLa-KB; Strain KB 43.0 nM IC50 C27677
TKC016794 PC-3 PC3; PC.3 18.0 nM IC50 C4863
TKC016794 MDA-MB-468 MDA-MB 468; MDA-MB468; MDAMB468; MDA-468; MDA468; MB468; MD Anderson-Metastatic Breast-468 10.0 nM IC50 C5214
TKC016794 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 6.0 nM IC50 C7978
TKC016794 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 8.0 nM GI50 C9142 Orphanet_99861
TKC016794 K562 K562; K.562; K 562; KO; GM05372; GM05372E 17.0 nM GI50 C9110 Orphanet_521
TKC016794 SGC-7901 SGC 7901; SGC7901 15.0 nM IC50 C27677
TKC016794 MKN-28 MKN-28; MKN 28 200.0 nM IC50 C5473
TKC016794 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 5.0 nM IC50 C4910
TKC016794 HCT-15 HCT-15; HCT.15; HCT15 14.0 nM GI50 C4349
TKC016794 SMMC-7721 SMMC 7721; SMMC7721; H7721; H-7721 18.0 nM IC50 C27677
TKC016794 Bel-7402 Bel-7402; BEL 7402; Bel 7402; BEL7402; Bel7402 20.0 nM IC50 C27677
TKC016794 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 14.0 nM GI50 C5214
TKC016794 MCF7 4.0 nM GI50 C4194
TKC016794 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 24.0 nM IC50 C4863
TKC016794 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 47.0 nM IC50 C27677
TKC016794 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 33.0 nM IC50 C60781 Orphanet_94
TKC016794 MEF 9200.0 nM IC50 C3043 Orphanet_2030
TKC016794 SN12C SN-12C 9.0 nM GI50 C9385 Orphanet_217071
TKC016794 MDA-N MDAN 8.0 nM GI50 C3802
TKC016794 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 3.0 nM GI50 C3512
TKC016794 ACHN 7.0 nM GI50 C6975 Orphanet_319298
TKC016794 UO-31 UO.31; UO31; U031 12.0 nM GI50 C9385 Orphanet_217071
TKC016794 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 23.0 nM GI50 C2926
TKC016794 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 7.0 nM GI50 C9154 Orphanet_519
TKC016794 SF-539 SF-539; SF-539 BT; SF.539; SF 539 7.0 nM GI50 C3796 Orphanet_251576
TKC016794 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 7.0 nM GI50 C3510
TKC016794 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 11.0 nM GI50 C3224
TKC016794 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 6.0 nM GI50 C105555
TKC016794 A498 A498 18.0 nM GI50 C9385 Orphanet_217071
TKC016794 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 7.0 nM GI50 C3512
TKC016794 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 26.0 nM GI50 C105555
TKC016794 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 20.0 nM GI50 C105555
TKC016794 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 21.0 nM GI50 C105555
TKC016794 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 104.0 nM GI50 C60781 Orphanet_94
TKC016794 SR SR-786; SR786 17.0 nM GI50 C37193 Orphanet_300895
TKC016794 TK-10 TK.10; TK 10; TK10 14.0 nM GI50 C4033 Orphanet_319276
TKC016794 SW-620 SW-620; SW 620; SW.620 14.0 nM GI50 C4349
TKC016794 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 9.0 nM GI50 C3512
TKC016794 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 14.0 nM GI50 C3802
TKC016794 KM12 KM-12; KM.12 27.0 nM GI50 C4910
TKC016794 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 11.0 nM GI50 C2923
TKC016794 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 5.0 nM GI50 C3242 Orphanet_29073
TKC016794 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 8.0 nM GI50 C105555
TKC016794 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 5.0 nM GI50 C3802
TKC016794 BT-549 BT 549; BT.549; BT549 11.0 nM GI50 C4194
TKC016794 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 6.0 nM GI50 C3224
TKC016794 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 10.0 nM GI50 C3058 Orphanet_360
TKC016794 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 18.0 nM GI50 C4349
TKC016794 SF-268 SF-268; SF.268; SF 268 25.0 nM GI50 C60781 Orphanet_94
TKC016794 EKVX 21.0 nM GI50 C3512
TKC016794 T47D 19.0 nM GI50 C4194
TKC016794 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 4.0 nM GI50 C3224
TKC016794 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 5.0 nM GI50 C4450
TKC016794 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 7.0 nM GI50 C3802
TKC016794 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 6.0 nM GI50 C3224
TKC016794 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 7.0 nM GI50 C7979 Orphanet_454723
TKC016794 SF-295 SF-295; SF.295; SF 295 28.0 nM GI50 C3058 Orphanet_360
TKC016794 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 15.0 nM GI50 C4194
TKC016794 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 17.0 nM GI50 C9385 Orphanet_217071
TKC016794 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 11.0 nM GI50 C7953 Orphanet_99861
TKC016794 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 13.0 nM GI50 C3224
TKC016794 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 22.0 nM GI50 C45662 Orphanet_50251
TKC016794 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 6.0 nM GI50 C3510
TKC016794 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 8.0 nM GI50 C4349
TKC016794 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 8.0 nM GI50 C9385 Orphanet_217071
TKC016794 MDCK MDCK (NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney 1200.0 nM IC50
TKC016794 Jurkat JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024 140.0 nM IC50 C7953 Orphanet_99861
TKC016794 NIH3T3 NIH/3T3; NIH-3T3; NIH3T3; 3T3; 3T3NIH; 3T3-Swiss; Swiss-3T3; Swiss/3T3; Swiss 3T3; Swiss3T3 50.0 nM IC50
TKC016794 HepG2 43.0 nM IC50 C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC016794 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 121 nM Potency
TKC016794 P0DTD1 Replicase polyprotein 1ab rep -6 % Inhibition
TKC016794 P35354 Prostaglandin G/H synthase 2 PTGS2 40 nM IC50
TKC016794 Q01196 Runt-related transcription factor 1 RUNX1 28184 nM Potency
TKC016794 Q9F4F7 4'-phosphopantetheinyl transferase ffp ffp 14125 nM Potency
TKC016794 P51450 Nuclear receptor ROR-gamma Rorc 316 nM Potency
TKC016794 P02545 Prelamin-A/C LMNA 89 nM Potency
TKC016794 O15118 NPC intracellular cholesterol transporter 1 NPC1 89 nM Potency
TKC016794 P51151 Ras-related protein Rab-9A RAB9A 1000 nM Potency
TKC016794 P55085 Proteinase-activated receptor 2 F2RL1 14 nM IC50
TKC016794 Q00613 Heat shock factor protein 1 HSF1 35 % Activity
TKC016794 Q9H773 dCTP pyrophosphatase 1 DCTPP1 30900 nM IC50
TKC016794 Q9H773 dCTP pyrophosphatase 1 DCTPP1 168000 nM Ki
TKC016794 Q9H773 dCTP pyrophosphatase 1 DCTPP1 30900 nM IC50
TKC016794 Q9H773 dCTP pyrophosphatase 1 DCTPP1 30900 nM IC50
TKC016794 Q9H773 dCTP pyrophosphatase 1 DCTPP1 30900 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P35354 PGH2_HUMAN Alzheimer disease [ICD-11: 8A20]
P35354 PGH2_HUMAN Chronic pain [ICD-11: MG30]
P35354 PGH2_HUMAN Endometriosis [ICD-11: GA10]
P35354 PGH2_HUMAN Female pelvic pain [ICD-11: GA34]
P35354 PGH2_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
P35354 PGH2_HUMAN Indeterminate colitis [ICD-11: DD72]
P35354 PGH2_HUMAN Knee osteoarthritis [ICD-11: FA01]
P35354 PGH2_HUMAN Migraine [ICD-11: 8A80]
P35354 PGH2_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
P35354 PGH2_HUMAN Pain [ICD-11: MG30-MG3Z]
P35354 PGH2_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P35354 PGH2_HUMAN Tuberculosis [ICD-11: 1B10-1B12]
P35354 PGH2_HUMAN Shoulder lesion [ICD-11: FB53]
P35354 PGH2_HUMAN Soft tissue disorder [ICD-11: FB56]
P35354 PGH2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P35354 PGH2_HUMAN Asthma [ICD-11: CA23]
P35354 PGH2_HUMAN Gout [ICD-11: FA25]
P35354 PGH2_HUMAN General pain disorder [ICD-11: 8E43]
P35354 PGH2_HUMAN Lupus erythematosus [ICD-11: 4A40]
P35354 PGH2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P35354 PGH2_HUMAN Large intestine polyp [ICD-11: DB35]
P35354 PGH2_HUMAN Lung cancer [ICD-11: 2C25]
P35354 PGH2_HUMAN Pancreatic cancer [ICD-11: 2C10]
P35354 PGH2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P35354 PGH2_HUMAN Colorectal cancer [ICD-11: 2B91]
P35354 PGH2_HUMAN Fever [ICD-11: MG26]
P35354 PGH2_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
P55085 PAR2_HUMAN Acquired cutaneous blood vessel malformation [ICD-11: EF20]
P55085 PAR2_HUMAN Arterial occlusive disease [ICD-11: BD40]
P55085 PAR2_HUMAN Atopic eczema [ICD-11: EA80]
P55085 PAR2_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P55085 PAR2_HUMAN Digestive system disease [ICD-11: DE2Z]
P55085 PAR2_HUMAN Gastric ulcer [ICD-11: DA60]
P55085 PAR2_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
P55085 PAR2_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P55085 PAR2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P55085 PAR2_HUMAN Pain [ICD-11: MG30-MG3Z]
P55085 PAR2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P55085 PAR2_HUMAN Psoriasis [ICD-11: EA90]
P55085 PAR2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P55085 PAR2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]