Basic Information

Terpenoid ID TKC112787
Cell line 0
Protein target 4
DiseaseNCIT 0
ORDO 0
ICD 3

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC112787 MDA-N MDAN 100000.0 nM GI50 C3802
TKC112787 SN12C SN-12C 100000.0 nM GI50 C9385 Orphanet_217071
TKC112787 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 100000.0 nM GI50 C3512
TKC112787 UO-31 UO.31; UO31; U031 100000.0 nM GI50 C9385 Orphanet_217071
TKC112787 ACHN 100000.0 nM GI50 C6975 Orphanet_319298
TKC112787 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 100000.0 nM GI50 C9154 Orphanet_519
TKC112787 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 100000.0 nM GI50 C2926
TKC112787 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 100000.0 nM GI50 C4863
TKC112787 SF-539 SF-539; SF-539 BT; SF.539; SF 539 100000.0 nM GI50 C3796 Orphanet_251576
TKC112787 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 100000.0 nM GI50 C3224
TKC112787 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 100000.0 nM GI50 C3510
TKC112787 A498 A498 100000.0 nM GI50 C9385 Orphanet_217071
TKC112787 K562 K562; K.562; K 562; KO; GM05372; GM05372E 100000.0 nM GI50 C9110 Orphanet_521
TKC112787 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 100000.0 nM GI50 C105555
TKC112787 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 90991.0 nM GI50 C9142 Orphanet_99861
TKC112787 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 100000.0 nM GI50 C3512
TKC112787 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 100000.0 nM GI50 C60781 Orphanet_94
TKC112787 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 100000.0 nM GI50 C105555
TKC112787 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 100000.0 nM GI50 C105555
TKC112787 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 100000.0 nM GI50 C105555
TKC112787 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 100000.0 nM GI50 C60781 Orphanet_94
TKC112787 SR SR-786; SR786 28708.0 nM GI50 C37193 Orphanet_300895
TKC112787 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 100000.0 nM GI50 C5214
TKC112787 SW-620 SW-620; SW 620; SW.620 100000.0 nM GI50 C4349
TKC112787 TK-10 TK.10; TK 10; TK10 100000.0 nM GI50 C4033 Orphanet_319276
TKC112787 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 100000.0 nM GI50 C3512
TKC112787 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 100000.0 nM GI50 C3802
TKC112787 KM12 KM-12; KM.12 100000.0 nM GI50 C4910
TKC112787 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 100000.0 nM GI50 C2923
TKC112787 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 100000.0 nM GI50 C3242 Orphanet_29073
TKC112787 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 100000.0 nM GI50 C105555
TKC112787 BT-549 BT 549; BT.549; BT549 100000.0 nM GI50 C4194
TKC112787 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 100000.0 nM GI50 C3802
TKC112787 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 100000.0 nM GI50 C3224
TKC112787 A549 100000.0 nM GI50 C3512
TKC112787 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 100000.0 nM GI50 C4349
TKC112787 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 100000.0 nM GI50 C3058 Orphanet_360
TKC112787 HCT-15 HCT-15; HCT.15; HCT15 100000.0 nM GI50 C4349
TKC112787 SF-268 SF-268; SF.268; SF 268 100000.0 nM GI50 C60781 Orphanet_94
TKC112787 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 100000.0 nM GI50 C4910
TKC112787 EKVX 100000.0 nM GI50 C3512
TKC112787 MCF7 100000.0 nM GI50 C4194
TKC112787 PC-3 PC3; PC.3 100000.0 nM GI50 C4863
TKC112787 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 100000.0 nM GI50 C7978
TKC112787 T47D 100000.0 nM GI50 C4194
TKC112787 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 100000.0 nM GI50 C4450
TKC112787 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 100000.0 nM GI50 C3224
TKC112787 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 100000.0 nM GI50 C3224
TKC112787 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 100000.0 nM GI50 C3802
TKC112787 SF-295 SF-295; SF.295; SF 295 100000.0 nM GI50 C3058 Orphanet_360
TKC112787 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 100000.0 nM GI50 C7979 Orphanet_454723
TKC112787 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 100000.0 nM GI50 C4194
TKC112787 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 100000.0 nM GI50 C3224
TKC112787 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 100000.0 nM GI50 C9385 Orphanet_217071
TKC112787 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 100000.0 nM GI50 C7953 Orphanet_99861
TKC112787 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 100000.0 nM GI50 C45662 Orphanet_50251
TKC112787 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 100000.0 nM GI50 C3510
TKC112787 HT-29 HT 29; HT29 100000.0 nM GI50 C4349
TKC112787 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 100000.0 nM GI50 C9385 Orphanet_217071
TKC112787 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 100000.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC112787 P11473 Vitamin D3 receptor VDR >14500 nM IC50
TKC112787 P20309 Muscarinic acetylcholine receptor M3 CHRM3 >10000 nM Ki
TKC112787 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 90 % Inhibition
TKC112787 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 98 % Inhibition
TKC112787 P08183 ATP-dependent translocase ABCB1 ABCB1 40 % Activity
TKC112787 P08482 Muscarinic acetylcholine receptor M1 Chrm1 >10000 nM Ki
TKC112787 O15439 ATP-binding cassette sub-family C member 4 ABCC4 20000 nM IC50
TKC112787 O94956 Solute carrier organic anion transporter family member 2B1 SLCO2B1 95 % Inhibition
TKC112787 O95342 Bile salt export pump ABCB11 189200 nM IC50
TKC112787 Q92887 ATP-binding cassette sub-family C member 2 ABCC2 27 % Activity
TKC112787 Q96RI1 Bile acid receptor NR1H4 5 % Activity
TKC112787 P04054 Phospholipase A2 PLA2G1B 40 % Activity
TKC112787 Q9UNQ0 Broad substrate specificity ATP-binding cassette transporter ABCG2 ABCG2 20 % Activity
TKC112787 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 290 nM EC50
TKC112787 P33527 Multidrug resistance-associated protein 1 ABCC1 56 % Activity
TKC112787 Q14973 Sodium/bile acid cotransporter SLC10A1 33 % Activity
TKC112787 Q6PSM0 Multidrug resistance protein 1a Mdr1a 16 % Activity
TKC112787 P08483 Muscarinic acetylcholine receptor M3 Chrm3 >10000 nM Ki
TKC112787 Q03145 Ephrin type-A receptor 2 Epha2 72000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P20309 ACM3_HUMAN Asthma [ICD-11: CA23]
P20309 ACM3_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P20309 ACM3_HUMAN Functional bladder disorder [ICD-11: GC50]
P20309 ACM3_HUMAN Glaucoma [ICD-11: 9C61]
P20309 ACM3_HUMAN Nausea/vomiting [ICD-11: MD90]
P20309 ACM3_HUMAN Peptic ulcer [ICD-11: DA61]
P20309 ACM3_HUMAN Respiratory system disease [ICD-11: CB40-CB7Z]
P20309 ACM3_HUMAN Sebaceous gland disorder [ICD-11: ED91]
P20309 ACM3_HUMAN Sjogren syndrome [ICD-11: 4A43]
P20309 ACM3_HUMAN Tonus and reflex abnormality [ICD-11: MB47]
P20309 ACM3_HUMAN Abnormal micturition [ICD-11: MF50]
P20309 ACM3_HUMAN Alzheimer disease [ICD-11: 8A20]
P08183 MDR1_HUMAN Lung cancer [ICD-11: 2C25]
P08183 MDR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08183 MDR1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P08183 MDR1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P08183 MDR1_HUMAN Adrenal cancer [ICD-11: 2D11]
P08183 MDR1_HUMAN Ovarian cancer [ICD-11: 2C73]
Q96RI1 NR1H4_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q96RI1 NR1H4_HUMAN Cholelithiasis [ICD-11: DC11]
Q96RI1 NR1H4_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
Q96RI1 NR1H4_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
Q96RI1 NR1H4_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96RI1 NR1H4_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q96RI1 NR1H4_HUMAN Chronic kidney disease [ICD-11: GB61]
Q96RI1 NR1H4_HUMAN Skeletal anomaly [ICD-11: LD24]
Q96RI1 NR1H4_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q96RI1 NR1H4_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q96RI1 NR1H4_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P04054 PA21B_HUMAN Leishmaniasis [ICD-11: 1F54]
P04054 PA21B_HUMAN Lichen planus [ICD-11: EA91]
P04054 PA21B_HUMAN Peroxisomal disease [ICD-11: 5C57]
P04054 PA21B_HUMAN Rosacea [ICD-11: ED90]
P04054 PA21B_HUMAN Synthesis disorder [ICD-11: 5C52-5C59]
P04054 PA21B_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P04054 PA21B_HUMAN Contact dermatitis [ICD-11: EK00-EK0Z]
P04054 PA21B_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P04054 PA21B_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P04054 PA21B_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
P04054 PA21B_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04054 PA21B_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P04054 PA21B_HUMAN Asthma [ICD-11: CA23]
P04054 PA21B_HUMAN Pruritus [ICD-11: EC90]
P04054 PA21B_HUMAN Unspecific body region injury [ICD-11: ND56]
P04054 PA21B_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q9UNQ0 ABCG2_HUMAN Irritable bowel syndrome [ICD-11: DD91]
Q9UNQ0 ABCG2_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P33527 MRP1_HUMAN Gout [ICD-11: FA25]
Q14973 NTCP_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q14973 NTCP_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q14973 NTCP_HUMAN Gallbladder/bile ducts/liver structural developmental anomaly [ICD-11: LB20]
Q14973 NTCP_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]