Basic Information

Terpenoid ID TKC152765
Cell line 0
Protein target 1
DiseaseNCIT 0
ORDO 0
ICD 11

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC152765 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 12200.0 nM GI50 C9154 Orphanet_519
TKC152765 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 12700.0 nM GI50 C7978
TKC152765 A549 11100.0 nM GI50 C3512
TKC152765 HT-29 HT 29; HT29 13500.0 nM GI50 C4349
TKC152765 RAW264.7 RAW264 24.0 % Inhibition C21604
TKC152765 HepG2 16.0 U/L Activity C3728 Orphanet_449
TKC152765 HepG2 2.2.15 HEP-G2/2.2.15; Hep-G2/2215; HepG2/2215; HepG2-2.2.15; HepG2 2.2.15; HepG2.2.15; HepG2(2.2.15); 2.2.15 1787400.0 nM CC50 C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC152765 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 90 % Inhibition
TKC152765 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 112 % Inhibition
TKC152765 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 104 % Activity
TKC152765 P29477 Nitric oxide synthase, inducible Nos2 >50000 nM IC50
TKC152765 O42275 Acetylcholinesterase ache -4 % Inhibition
TKC152765 P81908 Cholinesterase BCHE -1 % Inhibition
TKC152765 Q96RI1 Bile acid receptor NR1H4 0 nM EC50
TKC152765 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 >0 % Efficacy

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q96RI1 NR1H4_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q96RI1 NR1H4_HUMAN Cholelithiasis [ICD-11: DC11]
Q96RI1 NR1H4_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
Q96RI1 NR1H4_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
Q96RI1 NR1H4_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96RI1 NR1H4_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q96RI1 NR1H4_HUMAN Chronic kidney disease [ICD-11: GB61]
Q96RI1 NR1H4_HUMAN Skeletal anomaly [ICD-11: LD24]
Q96RI1 NR1H4_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q96RI1 NR1H4_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q96RI1 NR1H4_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]