Basic Information

Terpenoid ID TKC141147
Cell line 0
Protein target 10
DiseaseNCIT 0
ORDO 0
ICD 25

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC141147 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 26000.0 nM IC50 C3224
TKC141147 KB KB (HeLa derivative); HeLa-KB; Strain KB 3800.0 nM IC50 C27677
TKC141147 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 1.0 ug ml-1 ED50 C9142 Orphanet_99861
TKC141147 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 8400.0 nM IC50 C7953 Orphanet_99861
TKC141147 BRISTOL8 BRISTOL 8; Bristol-8; BRISTOL-8; BRISTOL8; Bri-8; BRI-8; BRI 8; GM03357; GM3357; GM03357B 3.0 ug ml-1 ED50
TKC141147 U-937 U937; U 937 3.0 ug ml-1 ED50 C8263 Orphanet_514
TKC141147 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 36000.0 nM IC50 C4863
TKC141147 PA-1 PA1; PA I; PAI 1.0 ug ml-1 ED50 C8114 Orphanet_180234
TKC141147 K562 K562; K.562; K 562; KO; GM05372; GM05372E 6000.0 nM IC50 C9110 Orphanet_521
TKC141147 MCF7 10000.0 nM IC50 C4194
TKC141147 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 36800.0 nM IC50 C4349
TKC141147 HT-29 HT 29; HT29 10020.0 nM IC50 C4349
TKC141147 PC-3 PC3; PC.3 10000.0 nM IC50 C4863
TKC141147 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 400000.0 nM CC50
TKC141147 H9 HT clone H9; HT(H9); H 9; H-9 2.0 ug.mL-1 IC50 C3366 Orphanet_3162
TKC141147 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 2610.0 nM IC50 C4910
TKC141147 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 9770.0 nM IC50 C5214
TKC141147 SW948 SW-948; SW 948 19170.0 nM IC50 C4349
TKC141147 A-431 A431; A431/P 3260.0 nM IC50 C4819
TKC141147 A2780 A-2780; 2780; A2780S; A2780par 2980.0 nM IC50 C7979 Orphanet_454723
TKC141147 SW-1736 SW-1736; SW 1736 3050.0 nM IC50 C3878 Orphanet_142
TKC141147 HepG2 4.0 ug.mL-1 IC50 C3728 Orphanet_449
TKC141147 Ca9-22 CA9-22; Ca 9-22; CA922; Ca922 14.0 ug.mL-1 IC50 C129857 Orphanet_502363
TKC141147 8505C 8505c 14000.0 nM IC50 C3878 Orphanet_142
TKC141147 Bcap37 BCap-37; Bcap-37; BCaP 37; BCap 37; Bcap 37; BCAP37; Bcap37 25700.0 nM IC50 C27677
TKC141147 MGC-803 MGC803; MGc80-3 17700.0 nM IC50 C5248
TKC141147 A-375 A 375; A375; A375-MEL; A375-mel; A375mel 28900.0 nM IC50 C3802
TKC141147 J774 J-774 38.0 % Activity C134780
TKC141147 MIA PaCa-2 MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2; MiaPaCa 10000.0 nM IC50 C9120
TKC141147 SiHa Siha; SIHA 500000.0 nM IC50 C27676 Orphanet_213767
TKC141147 U2OS U-2 OS; U-2OS; U-2-OS; U2-OS; U20-S; U20S; 2T 38000.0 nM IC50 C9145 Orphanet_668
TKC141147 BJ 39500.0 nM IC50
TKC141147 MRC5 MRC5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5 29500.0 nM IC50

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC141147 Q16637 Survival motor neuron protein SMN1,SMN2 15849 nM Potency
TKC141147 Q16637 Survival motor neuron protein SMN1,SMN2 15849 nM Potency
TKC141147 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 2909 nM Potency
TKC141147 P53350 Serine/threonine-protein kinase PLK1 PLK1 13371 nM Potency
TKC141147 Q9UNA4 DNA polymerase iota POLI 1413 nM Potency
TKC141147 O75496 Geminin GMNN 4110 nM Potency
TKC141147 P25779 Cruzipain 5012 nM Potency
TKC141147 P10520 Streptokinase A ska 1848 nM EC50
TKC141147 P02545 Prelamin-A/C LMNA 794 nM Potency
TKC141147 Q96RI1 Bile acid receptor NR1H4 0 nM EC50
TKC141147 P0DPI0 Botulinum neurotoxin type A botA <100000 nM IC50
TKC141147 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 4710 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P25779 CYSP_TRYCR Parasitic worm infestation [ICD-11: 1F90]
P25779 CYSP_TRYCR Malaria [ICD-11: 1F40-1F45]
Q96RI1 NR1H4_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q96RI1 NR1H4_HUMAN Cholelithiasis [ICD-11: DC11]
Q96RI1 NR1H4_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
Q96RI1 NR1H4_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
Q96RI1 NR1H4_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96RI1 NR1H4_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q96RI1 NR1H4_HUMAN Chronic kidney disease [ICD-11: GB61]
Q96RI1 NR1H4_HUMAN Skeletal anomaly [ICD-11: LD24]
Q96RI1 NR1H4_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q96RI1 NR1H4_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q96RI1 NR1H4_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P0DPI0 BXA1_CLOBO Acne vulgaris [ICD-11: ED80]
P0DPI0 BXA1_CLOBO Ataxic disorder [ICD-11: 8A03]
P0DPI0 BXA1_CLOBO Clostridium difficile enterocolitis [ICD-11: 1A04]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]