Basic Information

Terpenoid ID TKC026895
Cell line 3
Protein target 1
DiseaseNCIT 2
ORDO 1
ICD 13

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC026895 HepG2 64.0 % Inhibition C3728 Orphanet_449
TKC026895 MCF7 7100.0 nM IC50 C4194
TKC026895 MDA-MB-468 MDA-MB 468; MDA-MB468; MDAMB468; MDA-468; MDA468; MB468; MD Anderson-Metastatic Breast-468 108.0 % Activity C5214
TKC026895 T47D 83.0 % Activity C4194
TKC026895 BT-549 BT 549; BT.549; BT549 141.0 % Activity C4194
TKC026895 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 100.0 % Activity C4863
TKC026895 PC-3 PC3; PC.3 97.0 % Activity C4863
TKC026895 UO-31 UO.31; UO31; U031 64.0 % Activity C9385 Orphanet_217071
TKC026895 TK-10 TK.10; TK 10; TK10 122.0 % Activity C4033 Orphanet_319276
TKC026895 SN12C SN-12C 96.0 % Activity C9385 Orphanet_217071
TKC026895 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 84.0 % Activity C9385 Orphanet_217071
TKC026895 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 90.0 % Activity C3224
TKC026895 ACHN 100.0 % Activity C6975 Orphanet_319298
TKC026895 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 114.0 % Activity C9385 Orphanet_217071
TKC026895 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 112.0 % Activity C105555
TKC026895 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 114.0 % Activity C105555
TKC026895 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 102.0 % Activity C105555
TKC026895 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 110.0 % Activity C105555
TKC026895 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 96.0 % Activity C7979 Orphanet_454723
TKC026895 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 108.0 % Activity C3224
TKC026895 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 123.0 % Activity C3224
TKC026895 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 99.0 % Activity C3510
TKC026895 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 97.0 % Activity C3510
TKC026895 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 91.0 % Activity C3224
TKC026895 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 102.0 % Activity C3802
TKC026895 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 109.0 % Activity C3802
TKC026895 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 92.0 % Activity C3224
TKC026895 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 90.0 % Activity C3802
TKC026895 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 102.0 % Activity C60781 Orphanet_94
TKC026895 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 84.0 % Activity C3058 Orphanet_360
TKC026895 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 114.0 % Activity C60781 Orphanet_94
TKC026895 SF-539 SF-539; SF-539 BT; SF.539; SF 539 101.0 % Activity C3796 Orphanet_251576
TKC026895 SF-295 SF-295; SF.295; SF 295 105.0 % Activity C3058 Orphanet_360
TKC026895 SF-268 SF-268; SF.268; SF 268 108.0 % Activity C60781 Orphanet_94
TKC026895 SW-620 SW-620; SW 620; SW.620 110.0 % Activity C4349
TKC026895 KM12 KM-12; KM.12 107.0 % Activity C4910
TKC026895 HT-29 HT 29; HT29 96.0 % Activity C4349
TKC026895 HCT-15 HCT-15; HCT.15; HCT15 102.0 % Activity C4349
TKC026895 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 109.0 % Activity C4910
TKC026895 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 94.0 % Activity C4349
TKC026895 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 69.0 % Activity C3512
TKC026895 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 105.0 % Activity C4450
TKC026895 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 95.0 % Activity C2923
TKC026895 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 93.0 % Activity C3512
TKC026895 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 91.0 % Activity C45662 Orphanet_50251
TKC026895 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 92.0 % Activity C2926
TKC026895 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 108.0 % Activity C3512
TKC026895 A549 105.0 % Activity C3512
TKC026895 SR SR-786; SR786 86.0 % Activity C37193 Orphanet_300895
TKC026895 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 78.0 % Activity C3242 Orphanet_29073
TKC026895 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 84.0 % Activity C9142 Orphanet_99861
TKC026895 K562 K562; K.562; K 562; KO; GM05372; GM05372E 85.0 % Activity C9110 Orphanet_521
TKC026895 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 86.0 % Activity C9154 Orphanet_519
TKC026895 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 84.0 % Activity C7953 Orphanet_99861
TKC026895 MCF-10A MCF 10A; MCF.10A; MCF10A; MCF10-A; MCF10a; MCF-10 Attached; Michigan Cancer Foundation-10A 4400.0 nM IC50
TKC026895 HepG2 2800.0 nM IC50 C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC026895 P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 61 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P04035 HMDH_HUMAN Blood/blood-forming organ sympton [ICD-11: MA14]
P04035 HMDH_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P04035 HMDH_HUMAN Dyslipidemia [ICD-11: 5C80-5C81]
P04035 HMDH_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
P04035 HMDH_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
P04035 HMDH_HUMAN Multiple myeloma [ICD-11: 2A83]
P04035 HMDH_HUMAN Multiple sclerosis [ICD-11: 8A40]
P04035 HMDH_HUMAN Myocardial infarction [ICD-11: BA41-BA43]
P04035 HMDH_HUMAN Pain [ICD-11: MG30-MG3Z]
P04035 HMDH_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P04035 HMDH_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04035 HMDH_HUMAN Coronary atherosclerosis [ICD-11: BA80]
P04035 HMDH_HUMAN Thrombosis [ICD-11: DB61-GB90]