Basic Information

Terpenoid ID TKC020732
Chirality TKC130223
Cell line 0
Protein target 6
DiseaseNCIT 0
ORDO 0
ICD 57

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC020732 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 100000.0 nM GI50 C4450
TKC020732 SN12C SN-12C 893305.0 nM GI50 C9385 Orphanet_217071
TKC020732 ACHN 870964.0 nM GI50 C6975 Orphanet_319298
TKC020732 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 933254.0 nM GI50 C3512
TKC020732 UO-31 UO.31; UO31; U031 924698.0 nM GI50 C9385 Orphanet_217071
TKC020732 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 841395.0 nM GI50 C2926
TKC020732 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 816582.0 nM GI50 C9154 Orphanet_519
TKC020732 SF-539 SF-539; SF-539 BT; SF.539; SF 539 899498.0 nM GI50 C3796 Orphanet_251576
TKC020732 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 885116.0 nM GI50 C3224
TKC020732 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 849180.0 nM GI50 C3510
TKC020732 A498 A498 905733.0 nM GI50 C9385 Orphanet_217071
TKC020732 K562 K562; K.562; K 562; KO; GM05372; GM05372E 812831.0 nM GI50 C9110 Orphanet_521
TKC020732 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 891251.0 nM GI50 C105555
TKC020732 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 1137627.0 nM GI50 C9142 Orphanet_99861
TKC020732 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 883080.0 nM GI50 C3512
TKC020732 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 787046.0 nM GI50 C60781 Orphanet_94
TKC020732 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 968278.0 nM GI50 C105555
TKC020732 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 1044720.0 nM GI50 C105555
TKC020732 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 993116.0 nM GI50 C4917 Orphanet_70573
TKC020732 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 905733.0 nM GI50 C60781 Orphanet_94
TKC020732 TK-10 TK.10; TK 10; TK10 1004616.0 nM GI50 C4033 Orphanet_319276
TKC020732 SR SR-786; SR786 889201.0 nM GI50 C37193 Orphanet_300895
TKC020732 M19-MEL M-19; M19 879023.0 nM GI50 C3802
TKC020732 SW-620 SW-620; SW 620; SW.620 895365.0 nM GI50 C4349
TKC020732 KM12 KM-12; KM.12 1023293.0 nM GI50 C4910
TKC020732 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 988553.0 nM GI50 C3512
TKC020732 XF498 XF-498; XF498 993116.0 nM GI50 C3058 Orphanet_360
TKC020732 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 893305.0 nM GI50 C3802
TKC020732 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 100000.0 nM GI50 C3242 Orphanet_29073
TKC020732 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 968278.0 nM GI50 C2923
TKC020732 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 963829.0 nM GI50 C105555
TKC020732 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 897429.0 nM GI50 C3802
TKC020732 KM-20L2 KM-20L2; KM 20L2; KM 2012 903649.0 nM GI50 C4349
TKC020732 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 797995.0 nM GI50 C3224
TKC020732 A549 968278.0 nM GI50 C3512
TKC020732 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 972747.0 nM GI50 C4349
TKC020732 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 864968.0 nM GI50 C3058 Orphanet_360
TKC020732 HCT-15 HCT-15; HCT.15; HCT15 891251.0 nM GI50 C4349
TKC020732 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 922571.0 nM GI50 C4910
TKC020732 SF-268 SF-268; SF.268; SF 268 944061.0 nM GI50 C60781 Orphanet_94
TKC020732 EKVX 1030386.0 nM GI50 C3512
TKC020732 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 891251.0 nM GI50 C4917 Orphanet_70573
TKC020732 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 1135011.0 nM GI50 C7978
TKC020732 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 855067.0 nM GI50 C2926
TKC020732 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 968278.0 nM GI50 C4450
TKC020732 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 837529.0 nM GI50 C3224
TKC020732 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 935406.0 nM GI50 C3224
TKC020732 SF-295 SF-295; SF.295; SF 295 924698.0 nM GI50 C3058 Orphanet_360
TKC020732 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 993116.0 nM GI50 C7979 Orphanet_454723
TKC020732 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 907821.0 nM GI50 C9385 Orphanet_217071
TKC020732 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 922571.0 nM GI50 C9385 Orphanet_217071
TKC020732 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 926830.0 nM GI50 C3224
TKC020732 SNB-78 SNB78; Surgical Neurology Branch-78 986279.0 nM GI50 C3058 Orphanet_360
TKC020732 DLD-1 DLD 1; DLD1; CoCL3 885116.0 nM GI50 C4349
TKC020732 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 826038.0 nM GI50 C7953 Orphanet_99861
TKC020732 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 829851.0 nM GI50 C45662 Orphanet_50251
TKC020732 HT-29 HT 29; HT29 922571.0 nM GI50 C4349
TKC020732 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 950605.0 nM GI50 C3510
TKC020732 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 981748.0 nM GI50 C9385 Orphanet_217071
TKC020732 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 1006932.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC020732 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 630957 nM Potency
TKC020732 P10828 Thyroid hormone receptor beta THRB 794328 nM Potency
TKC020732 P02545 Prelamin-A/C LMNA 794 nM Potency
TKC020732 Q03181 Peroxisome proliferator-activated receptor delta PPARD 1258925 nM Potency
TKC020732 P19793 Retinoic acid receptor RXR-alpha RXRA 1258925 nM Potency
TKC020732 P04637 Cellular tumor antigen p53 TP53 3162 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P10828 THB_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
P10828 THB_HUMAN Hypo-thyroidism [ICD-11: 5A00]
P10828 THB_HUMAN Inborn lipid metabolism error [ICD-11: 5C52]
P10828 THB_HUMAN Skin postprocedural disorder [ICD-11: EL8Y]
P10828 THB_HUMAN Thyrotoxicosis [ICD-11: 5A02]
Q03181 PPARD_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q03181 PPARD_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q03181 PPARD_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q03181 PPARD_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q03181 PPARD_HUMAN Obesity [ICD-11: 5B80-5B81]
Q03181 PPARD_HUMAN Alzheimer disease [ICD-11: 8A20]
Q03181 PPARD_HUMAN Dyslipidemia [ICD-11: 5C80-5C81]
Q03181 PPARD_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
Q03181 PPARD_HUMAN Diabetes mellitus [ICD-11: 5A10]
Q03181 PPARD_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P19793 RXRA_HUMAN Kaposi sarcoma [ICD-11: 2B57]
P19793 RXRA_HUMAN Mycosis fungoides [ICD-11: 2B01]
P04637 P53_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04637 P53_HUMAN Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
P04637 P53_HUMAN Metastatic liver/bile duct neoplasm [ICD-11: 2D80]
P04637 P53_HUMAN Transplant rejection [ICD-11: NE84]
P04637 P53_HUMAN Ovarian dysfunction [ICD-11: 5A80]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Bladder cancer [ICD-11: 2C94]
P04637 P53_HUMAN Brain cancer [ICD-11: 2A00]
P04637 P53_HUMAN Colorectal cancer [ICD-11: 2B91]
P04637 P53_HUMAN Esophageal cancer [ICD-11: 2B70]
P04637 P53_HUMAN Head and neck cancer [ICD-11: 2D42]
P04637 P53_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P04637 P53_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P04637 P53_HUMAN Ovarian cancer [ICD-11: 2C73]
P04637 P53_HUMAN Pancreatic cancer [ICD-11: 2C10]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Stomach cancer [ICD-11: 2B72]
P04637 P53_HUMAN Cervical cancer [ICD-11: 2C77]
P04637 P53_HUMAN Endometrial cancer [ICD-11: 2C76]
P04637 P53_HUMAN Fallopian tube cancer [ICD-11: 2C74]
P04637 P53_HUMAN Liposarcoma [ICD-11: 2B59]
P04637 P53_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P04637 P53_HUMAN Peritoneal cancer [ICD-11: 2C51]
P04637 P53_HUMAN Toxicity [ICD-11: N.A.]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Kidney failure [ICD-11: GB60-GB6Z]
P04637 P53_HUMAN Hearing disorder [ICD-11: AB50-AB57]