Basic Information

Terpenoid ID TKC039868
Chirality TKC151321
Cell line 0
Protein target 15
DiseaseNCIT 0
ORDO 0
ICD 2

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC039868 L6 L-6; L-6 myoblast 350000.0 nM CC50
TKC039868 HUVEC HUV-EC-C; HUVEC 1100.0 nM IC50
TKC039868 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 36900.0 nM EC50 C7953 Orphanet_99861
TKC039868 ADR5000 cell line CCRF ADR5000; CCRF-ADR5000; CEM/ADR5000; CEM/ADR 5000; CEM-ADR5000; CEM ADR5000; ADR5000 26900.0 nM EC50 C7953 Orphanet_99861
TKC039868 HepG2 50000.0 nM IC50 C3728 Orphanet_449
TKC039868 K562 K562; K.562; K 562; KO; GM05372; GM05372E 39030.0 nM IC50 C9110 Orphanet_521
TKC039868 PC-3 PC3; PC.3 39030.0 nM IC50 C4863
TKC039868 A-431 A431; A431/P 39030.0 nM IC50 C4819
TKC039868 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 39030.0 nM IC50 C4349
TKC039868 SK-N-DZ SKNDZ 40.0 % Activity C3270 Orphanet_635
TKC039868 BE(2)-C 42.0 % Activity C3270 Orphanet_635
TKC039868 SK-N-AS SKN-AS; SKNAS 22.0 % Activity C3270 Orphanet_635
TKC039868 HT-29 HT 29; HT29 1.0 ug ml-1 ED50 C4349
TKC039868 P388 P-388 1.0 ug ml-1 ED50 C21602
TKC039868 KB KB (HeLa derivative); HeLa-KB; Strain KB 1.0 ug ml-1 ED50 C27677
TKC039868 MDA-N MDAN 100000.0 nM GI50 C3802
TKC039868 SN12C SN-12C 92257.0 nM GI50 C9385 Orphanet_217071
TKC039868 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 100000.0 nM GI50 C3512
TKC039868 ACHN 100000.0 nM GI50 C6975 Orphanet_319298
TKC039868 UO-31 UO.31; UO31; U031 82224.0 nM GI50 C9385 Orphanet_217071
TKC039868 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 100000.0 nM GI50 C2926
TKC039868 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 37411.0 nM GI50 C9154 Orphanet_519
TKC039868 SF-539 SF-539; SF-539 BT; SF.539; SF 539 100000.0 nM GI50 C3796 Orphanet_251576
TKC039868 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 96161.0 nM GI50 C3510
TKC039868 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 100000.0 nM GI50 C3224
TKC039868 A498 A498 100000.0 nM GI50 C9385 Orphanet_217071
TKC039868 K562 K562; K.562; K 562; KO; GM05372; GM05372E 33113.0 nM GI50 C9110 Orphanet_521
TKC039868 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 67298.0 nM GI50 C105555
TKC039868 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 66069.0 nM GI50 C9142 Orphanet_99861
TKC039868 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 100000.0 nM GI50 C3512
TKC039868 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 100000.0 nM GI50 C60781 Orphanet_94
TKC039868 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 100000.0 nM GI50 C105555
TKC039868 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 100000.0 nM GI50 C105555
TKC039868 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 100000.0 nM GI50 C60781 Orphanet_94
TKC039868 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 100000.0 nM GI50 C4917 Orphanet_70573
TKC039868 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 62373.0 nM GI50 C5214
TKC039868 SR SR-786; SR786 100000.0 nM GI50 C37193 Orphanet_300895
TKC039868 M19-MEL M-19; M19 100000.0 nM GI50 C3802
TKC039868 TK-10 TK.10; TK 10; TK10 100000.0 nM GI50 C4033 Orphanet_319276
TKC039868 SW-620 SW-620; SW 620; SW.620 100000.0 nM GI50 C4349
TKC039868 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 45082.0 nM GI50 C3512
TKC039868 KM12 KM-12; KM.12 100000.0 nM GI50 C4910
TKC039868 XF498 XF-498; XF498 100000.0 nM GI50 C3058 Orphanet_360
TKC039868 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 100000.0 nM GI50 C3802
TKC039868 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 53211.0 nM GI50 C3242 Orphanet_29073
TKC039868 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 75336.0 nM GI50 C2923
TKC039868 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 97949.0 nM GI50 C3802
TKC039868 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 72778.0 nM GI50 C105555
TKC039868 BT-549 BT 549; BT.549; BT549 86497.0 nM GI50 C4194
TKC039868 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 100000.0 nM GI50 C3224
TKC039868 KM-20L2 KM-20L2; KM 20L2; KM 2012 100000.0 nM GI50 C4349
TKC039868 A549 89125.0 nM GI50 C3512
TKC039868 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 61660.0 nM GI50 C3058 Orphanet_360
TKC039868 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 100000.0 nM GI50 C4349
TKC039868 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 81658.0 nM GI50 C4910
TKC039868 HCT-15 HCT-15; HCT.15; HCT15 98401.0 nM GI50 C4349
TKC039868 SF-268 SF-268; SF.268; SF 268 100000.0 nM GI50 C60781 Orphanet_94
TKC039868 EKVX 97051.0 nM GI50 C3512
TKC039868 MCF7 100000.0 nM GI50 C4194
TKC039868 PC-3 PC3; PC.3 66834.0 nM GI50 C4863
TKC039868 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 65464.0 nM GI50 C2926
TKC039868 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 80353.0 nM GI50 C4917 Orphanet_70573
TKC039868 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 100000.0 nM GI50 C7978
TKC039868 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 100000.0 nM GI50 C3224
TKC039868 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 100000.0 nM GI50 C4450
TKC039868 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 100000.0 nM GI50 C3224
TKC039868 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 88920.0 nM GI50 C7979 Orphanet_454723
TKC039868 SF-295 SF-295; SF.295; SF 295 100000.0 nM GI50 C3058 Orphanet_360
TKC039868 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 100000.0 nM GI50 C9385 Orphanet_217071
TKC039868 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 100000.0 nM GI50 C4194
TKC039868 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 100000.0 nM GI50 C9385 Orphanet_217071
TKC039868 SNB-78 SNB78; Surgical Neurology Branch-78 100000.0 nM GI50 C3058 Orphanet_360
TKC039868 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 100000.0 nM GI50 C3224
TKC039868 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 82985.0 nM GI50 C7953 Orphanet_99861
TKC039868 DLD-1 DLD 1; DLD1; CoCL3 82794.0 nM GI50 C4349
TKC039868 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 100000.0 nM GI50 C45662 Orphanet_50251
TKC039868 HT-29 HT 29; HT29 100000.0 nM GI50 C4349
TKC039868 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 100000.0 nM GI50 C3510
TKC039868 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 100000.0 nM GI50 C4349
TKC039868 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 72946.0 nM GI50 C9385 Orphanet_217071
TKC039868 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 61802.0 nM GI50 C4450

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC039868 P00352 Retinal dehydrogenase 1 ALDH1A1 35481 nM Potency
TKC039868 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 820 nM Potency
TKC039868 P08684 Cytochrome P450 3A4 CYP3A4 10 % Drug metabolism
TKC039868 Q9UNA4 DNA polymerase iota POLI 89125 nM Potency
TKC039868 Q13148 TAR DNA-binding protein 43 TARDBP 4467 nM Potency
TKC039868 P0DTD1 Replicase polyprotein 1ab rep -5 % Inhibition
TKC039868 P11509 Cytochrome P450 2A6 CYP2A6 15 % Drug metabolism
TKC039868 P83916 Chromobox protein homolog 1 CBX1 100000 nM Potency
TKC039868 Q4QEW7 Dihydroorotate dehydrogenase DHODH 158489 nM IC50
TKC039868 P63096 Guanine nucleotide-binding protein G GNAI1 11220 nM Potency
TKC039868 P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD 39811 nM Potency
TKC039868 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 39811 nM Potency
TKC039868 Q9F4F7 4'-phosphopantetheinyl transferase ffp ffp 89125 nM Potency
TKC039868 O15438 ATP-binding cassette sub-family C member 3 ABCC3 133000 nM IC50
TKC039868 O15439 ATP-binding cassette sub-family C member 4 ABCC4 133000 nM IC50
TKC039868 O95342 Bile salt export pump ABCB11 133000 nM IC50
TKC039868 Q92887 ATP-binding cassette sub-family C member 2 ABCC2 133000 nM IC50
TKC039868 Q194T2 Non-structural protein 1 NS1 6310 nM Potency
TKC039868 P12821 Angiotensin-converting enzyme ACE 17 % Inhibition
TKC039868 Q02127 Dihydroorotate dehydrogenase DHODH 0 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
P11509 CP2A6_HUMAN Mycosis fungoides [ICD-11: 2B01]
P11509 CP2A6_HUMAN Psoriasis [ICD-11: EA90]
P12821 ACE_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P12821 ACE_HUMAN Heart failure [ICD-11: BD10-BD1Z]
P12821 ACE_HUMAN Hypertension [ICD-11: BA00-BA04]
P12821 ACE_HUMAN Thrombosis [ICD-11: DB61-GB90]
P12821 ACE_HUMAN Asthma [ICD-11: CA23]
P12821 ACE_HUMAN Hypotension [ICD-11: BA20-BA21]
P12821 ACE_HUMAN Chronic kidney disease [ICD-11: GB61]
P12821 ACE_HUMAN Kidney failure [ICD-11: GB60-GB6Z]
P12821 ACE_HUMAN Depression [ICD-11: 6A70-6A7Z]
Q02127 PYRD_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q02127 PYRD_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q02127 PYRD_HUMAN Multiple sclerosis [ICD-11: 8A40]
Q02127 PYRD_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q02127 PYRD_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q02127 PYRD_HUMAN COVID-19 [ICD-11: 1D6Y]
Q02127 PYRD_HUMAN Indeterminate colitis [ICD-11: DD72]
Q02127 PYRD_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
Q02127 PYRD_HUMAN Transplant rejection [ICD-11: NE84]