Basic Information
| Terpenoid ID | TKC016414 |
|
| Chirality | TKC016418 | |
| Cell line | 0 | |
| Protein target | 11 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 38 |
| Terpenoid ID | TKC016414 |
|
| Chirality | TKC016418 | |
| Cell line | 0 | |
| Protein target | 11 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 38 |
| ID | Cell Line | Synonyms | Value | Unit | Type | NCIt | ORDO |
|---|---|---|---|---|---|---|---|
| TKC016414 | A498 | A498 | 30.0 | uM | IG50 | C9385 | Orphanet_217071 |
| TKC016414 | NCI/ADR-RES | NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR | 15.0 | uM | IG50 | C105555 | |
| TKC016414 | U-251 | U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) | 3.0 | uM | IG50 | C60781 | Orphanet_94 |
| TKC016414 | SW-620 | SW-620; SW 620; SW.620 | 10.0 | uM | IG50 | C4349 | |
| TKC016414 | NCI-H522 | NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 | 17.0 | uM | IG50 | C3512 | |
| TKC016414 | SK-OV-3 | SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 | 15.0 | uM | IG50 | C7978 | |
| TKC016414 | DU-145 | DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 | 20.0 | uM | IG50 | C4863 | |
| TKC016414 | J774.A1 | J-774A.1; J774.A1; J774 A1; J774A.1; J 774A.1; J774 A.1 | 49.0 | % | Inhibition | C134780 | |
| TKC016414 | HL-60 | HL 60; HL.60 HL60; Human Leukemia-60 | 27000.0 | nM | IC50 | C9154 | Orphanet_519 |
| TKC016414 | U-937 | U937; U 937 | 12870.0 | nM | IC50 | C8263 | Orphanet_514 |
| TKC016414 | THP-1 | THP1; THP 1; THPI; THP-1(ATCC); THP-1-O; O-THP-1; Tohoku Hospital Pediatrics-1 | 6690.0 | nM | IC50 | C9163 | Orphanet_514 |
| TKC016414 | K562 | K562; K.562; K 562; KO; GM05372; GM05372E | 41850.0 | nM | IC50 | C9110 | Orphanet_521 |
| TKC016414 | A549 | 27900.0 | nM | IC50 | C3512 | ||
| TKC016414 | P388 | P-388 | 2250.0 | nM | IC50 | C21602 | |
| TKC016414 | KB | KB (HeLa derivative); HeLa-KB; Strain KB | 27370.0 | nM | IC50 | C27677 | |
| TKC016414 | Col2 | Col-2; Col2 | 14.0 | uM | ED50 | C4910 | |
| TKC016414 | MCF7 | 3000.0 | nM | GI50 | C4194 | ||
| TKC016414 | Lu1 | Lu1 | 13.0 | uM | ED50 | C21678 | |
| TKC016414 | RAW264.7 | RAW264 | 6960.0 | nM | IC50 | C21604 | |
| TKC016414 | HUVEC | HUV-EC-C; HUVEC | 10.0 | % | Inhibition | ||
| TKC016414 | HCT-116 | HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 | 23930.0 | nM | IC50 | C4910 | |
| TKC016414 | PC-3 | PC3; PC.3 | 30000.0 | nM | IC50 | C4863 | |
| TKC016414 | SGC-7901 | SGC 7901; SGC7901 | 21.0 | % | Inhibition | C27677 | |
| TKC016414 | HT-29 | HT 29; HT29 | 9340.0 | nM | IC50 | C4349 | |
| TKC016414 | 5637 | 35.0 | % | Inhibition | C4912 | ||
| TKC016414 | HEK293 | 25000.0 | nM | LC50 | |||
| TKC016414 | MDA-MB-231 | MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 | 16550.0 | nM | IC50 | C5214 | |
| TKC016414 | CCRF-CEM | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C | 23.0 | % | Activity | C7953 | Orphanet_99861 |
| TKC016414 | SR | SR-786; SR786 | 20.0 | % | GI | C37193 | Orphanet_300895 |
| TKC016414 | EKVX | 105.0 | % | Activity | C3512 | ||
| TKC016414 | NCI-H226 | NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 | 8.0 | % | GI | C45662 | Orphanet_50251 |
| TKC016414 | NCI-H23 | NCI.H23; NCI H23; H-23; H23; NCIH23 | 2.0 | % | GI | C3512 | |
| TKC016414 | NCI-H322M | NCI.H322M; H322M; H-322M; H-322m | 7.0 | % | GI | C2923 | |
| TKC016414 | NCI-H460 | NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 | 2.0 | % | GI | C4450 | |
| TKC016414 | KM12 | KM-12; KM.12 | 20.0 | % | GI | C4910 | |
| TKC016414 | M14 | M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 | 15.0 | % | GI | C3802 | |
| TKC016414 | MDA-MB-435 | MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 | 27.0 | % | GI | C3802 | |
| TKC016414 | SK-MEL-28 | SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 | 5.0 | % | GI | C3510 | |
| TKC016414 | SK-MEL-5 | SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel | 23.0 | % | GI | C3510 | |
| TKC016414 | 786-0 | 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT | 15.0 | % | GI | C9385 | Orphanet_217071 |
| TKC016414 | ACHN | 3.0 | ug.mL-1 | IC50 | C6975 | Orphanet_319298 | |
| TKC016414 | SN12C | SN-12C | 18.0 | % | GI | C9385 | Orphanet_217071 |
| TKC016414 | T47D | 12.0 | % | GI | C4194 | ||
| TKC016414 | MDA-MB-468 | MDA-MB 468; MDA-MB468; MDAMB468; MDA-468; MDA468; MB468; MD Anderson-Metastatic Breast-468 | 42.0 | % | Activity | C5214 | |
| TKC016414 | HeLa | HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri | 10.0 | ug.mL-1 | IC50 | C27677 | |
| TKC016414 | B16 | B-16; B16 melanoma; B16 subline B78; B78 | 8.0 | ug.mL-1 | IC50 | C21790 | |
| TKC016414 | NIH3T3 | NIH/3T3; NIH-3T3; NIH3T3; 3T3; 3T3NIH; 3T3-Swiss; Swiss-3T3; Swiss/3T3; Swiss 3T3; Swiss3T3 | 95280.0 | nM | IC50 | ||
| TKC016414 | BV-2 | BV2 | 77.0 | % | Inhibition | ||
| TKC016414 | RAW264.7 | RAW264 | 8810.0 | nM | IC50 | C21604 |
| ID | Uniport | Pref_name | Gene name | value | unit | type |
|---|---|---|---|---|---|---|
| TKC016414 | Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | 8200 | nM | Potency |
| TKC016414 | P31749 | RAC-alpha serine/threonine-protein kinase | AKT1 | 36 | % | Activity |
| TKC016414 | Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | SLCO1B3 | 85 | % | Inhibition |
| TKC016414 | Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | SLCO1B1 | 80 | % | Inhibition |
| TKC016414 | O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | IDH1 | 29093 | nM | Potency |
| TKC016414 | P84022 | Mothers against decapentaplegic homolog 3 | SMAD3 | 14125 | nM | Potency |
| TKC016414 | Q03431 | Parathyroid hormone/parathyroid hormone-related peptide receptor | PTH1R | 112202 | nM | Potency |
| TKC016414 | Q16236 | Nuclear factor erythroid 2-related factor 2 | NFE2L2 | 12589 | nM | Potency |
| TKC016414 | Q99700 | Ataxin-2 | ATXN2 | 35481 | nM | Potency |
| TKC016414 | P19838 | Nuclear factor NF-kappa-B p105 subunit | NFKB1 | 49600 | nM | IC50 |
| TKC016414 | O75496 | Geminin | GMNN | 2909 | nM | Potency |
| TKC016414 | Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | APOBEC3G | 22387 | nM | Potency |
| TKC016414 | Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | PIN1 | 100000 | nM | Potency |
| TKC016414 | P40763 | Signal transducer and activator of transcription 3 | STAT3 | >10000 | nM | EC50 |
| TKC016414 | O42275 | Acetylcholinesterase | ache | 25 | % | Inhibition |
| TKC016414 | P0DTD1 | Replicase polyprotein 1ab | rep | 6 | % | Inhibition |
| TKC016414 | P81908 | Cholinesterase | BCHE | 9 | % | Inhibition |
| TKC016414 | Q96RI1 | Bile acid receptor | NR1H4 | 9700 | nM | IC50 |
| TKC016414 | P52789 | Hexokinase-2 | HK2 | >50000 | nM | IC50 |
| Uniport ID | Uniport Name | ICD-11 |
|---|---|---|
| P31749 | AKT1_HUMAN | Brain cancer [ICD-11: 2A00] |
| P31749 | AKT1_HUMAN | Breast cancer [ICD-11: 2C60-2C6Y] |
| P31749 | AKT1_HUMAN | Central nervous system disease [ICD-11: 8A04-8D87] |
| P31749 | AKT1_HUMAN | Colorectal cancer [ICD-11: 2B91] |
| P31749 | AKT1_HUMAN | Diffuse large B-cell lymphoma [ICD-11: 2A81] |
| P31749 | AKT1_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| P31749 | AKT1_HUMAN | Prostate cancer [ICD-11: 2C82] |
| P31749 | AKT1_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P31749 | AKT1_HUMAN | Stomach cancer [ICD-11: 2B72] |
| P31749 | AKT1_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| P31749 | AKT1_HUMAN | Cardiovascular disease [ICD-11: BA00-BE2Z] |
| P31749 | AKT1_HUMAN | Injury [ICD-11: NA00-ND5Z] |
| P31749 | AKT1_HUMAN | Leukaemia [ICD-11: 2A60-2B33] |
| P31749 | AKT1_HUMAN | Lymphoma [ICD-11: 2A80-2A86] |
| P31749 | AKT1_HUMAN | Multiple myeloma [ICD-11: 2A83] |
| P31749 | AKT1_HUMAN | Ovarian cancer [ICD-11: 2C73] |
| P31749 | AKT1_HUMAN | Overgrowth syndrome [ICD-11: LD2C] |
| P31749 | AKT1_HUMAN | Pancreatic cancer [ICD-11: 2C10] |
| P31749 | AKT1_HUMAN | Parkinsonism [ICD-11: 8A00] |
| P31749 | AKT1_HUMAN | Renal cell carcinoma [ICD-11: 2C90] |
| P31749 | AKT1_HUMAN | Arterial occlusive disease [ICD-11: BD40] |
| O75874 | IDHC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| O75874 | IDHC_HUMAN | Liver cancer [ICD-11: 2C12] |
| O75874 | IDHC_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| O75874 | IDHC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| O75874 | IDHC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| O75874 | IDHC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P84022 | SMAD3_HUMAN | Herpes simplex infection [ICD-11: 1F00] |
| P84022 | SMAD3_HUMAN | Kidney fibrosis [ICD-11: GC01] |
| Q03431 | PTH1R_HUMAN | Low bone mass disorder [ICD-11: FB83] |
| Q03431 | PTH1R_HUMAN | Hypo-parathyroidism [ICD-11: 5A50] |
| Q16236 | NF2L2_HUMAN | Ataxic disorder [ICD-11: 8A03] |
| Q16236 | NF2L2_HUMAN | Breast cancer [ICD-11: 2C60-2C6Y] |
| Q16236 | NF2L2_HUMAN | Glaucoma [ICD-11: 9C61] |
| Q16236 | NF2L2_HUMAN | Lung cancer [ICD-11: 2C25] |
| Q16236 | NF2L2_HUMAN | Macular degeneration [ICD-11: 9B75] |
| Q16236 | NF2L2_HUMAN | Melanoma [ICD-11: 2C30] |
| Q16236 | NF2L2_HUMAN | Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z] |
| Q16236 | NF2L2_HUMAN | Pulmonary hypertension [ICD-11: BB01] |
| Q16236 | NF2L2_HUMAN | Subarachnoid haemorrhage [ICD-11: 8B01] |
| Q16236 | NF2L2_HUMAN | Urinary system clinical sympton [ICD-11: MF8Y] |
| Q16236 | NF2L2_HUMAN | Non-alcoholic fatty liver disease [ICD-11: DB92] |
| Q16236 | NF2L2_HUMAN | Alpha-1-antitrypsin deficiency [ICD-11: 5C5A] |
| Q16236 | NF2L2_HUMAN | Motor neuron disease [ICD-11: 8B60] |
| Q16236 | NF2L2_HUMAN | Multiple sclerosis [ICD-11: 8A40] |
| P19838 | NFKB1_HUMAN | Muscular dystrophy [ICD-11: 8C70] |
| P19838 | NFKB1_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P19838 | NFKB1_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| Q13526 | PIN1_HUMAN | Lung cancer [ICD-11: 2C25] |
| Q13526 | PIN1_HUMAN | Nasopharyngeal cancer [ICD-11: 2B6B] |
| P40763 | STAT3_HUMAN | Psoriasis [ICD-11: EA90] |
| P40763 | STAT3_HUMAN | Brain cancer [ICD-11: 2A00] |
| P40763 | STAT3_HUMAN | Colorectal cancer [ICD-11: 2B91] |
| P40763 | STAT3_HUMAN | Liver cancer [ICD-11: 2C12] |
| P40763 | STAT3_HUMAN | Malignant digestive organ neoplasm [ICD-11: 2C11] |
| P40763 | STAT3_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| P40763 | STAT3_HUMAN | Pancreatic cancer [ICD-11: 2C10] |
| P40763 | STAT3_HUMAN | Respiratory infection [ICD-11: CA07-CA4Z] |
| P40763 | STAT3_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P40763 | STAT3_HUMAN | Immune system disease [ICD-11: 4A01-4B41] |
| P40763 | STAT3_HUMAN | Postoperative inflammation [ICD-11: 1A00-CA43] |
| P40763 | STAT3_HUMAN | Mature B-cell leukaemia [ICD-11: 2A82] |
| P40763 | STAT3_HUMAN | Multiple myeloma [ICD-11: 2A83] |
| P40763 | STAT3_HUMAN | Mycosis fungoides [ICD-11: 2B01] |
| P40763 | STAT3_HUMAN | Ulcerative colitis [ICD-11: DD71] |
| P40763 | STAT3_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| Q96RI1 | NR1H4_HUMAN | Autoimmune liver disease [ICD-11: DB96] |
| Q96RI1 | NR1H4_HUMAN | Cholelithiasis [ICD-11: DC11] |
| Q96RI1 | NR1H4_HUMAN | Insomnia [ICD-11: 7A00-7A0Z] |
| Q96RI1 | NR1H4_HUMAN | Osteoarthritis [ICD-11: FA00-FA05] |
| Q96RI1 | NR1H4_HUMAN | Breast cancer [ICD-11: 2C60-2C6Y] |
| Q96RI1 | NR1H4_HUMAN | Non-alcoholic fatty liver disease [ICD-11: DB92] |
| Q96RI1 | NR1H4_HUMAN | Chronic kidney disease [ICD-11: GB61] |
| Q96RI1 | NR1H4_HUMAN | Skeletal anomaly [ICD-11: LD24] |
| Q96RI1 | NR1H4_HUMAN | Hepatic fibrosis/cirrhosis [ICD-11: DB93] |
| Q96RI1 | NR1H4_HUMAN | Hyper-lipoproteinaemia [ICD-11: 5C80] |
| Q96RI1 | NR1H4_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| P52789 | HXK2_HUMAN | Epidermal dysplasias [ICD-11: EK90] |