Basic Information

Terpenoid ID TKC109622
Chirality TKC206671
Cell line 0
Protein target 10
DiseaseNCIT 0
ORDO 0
ICD 30

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC109622 P0DTD1 Replicase polyprotein 1ab rep 16 % Inhibition
TKC109622 O15439 ATP-binding cassette sub-family C member 4 ABCC4 26 % Activity
TKC109622 O95342 Bile salt export pump ABCB11 11900 nM Km
TKC109622 Q96RI1 Bile acid receptor NR1H4 2 % Activity
TKC109622 P04054 Phospholipase A2 PLA2G1B 10000 nM Kd
TKC109622 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 13000 nM Km
TKC109622 O70127 Bile salt export pump Abcb11 4100 nM Km
TKC109622 O35913 Solute carrier organic anion transporter family member 1A4 Slco1a4 17000 nM Km
TKC109622 O88397 Solute carrier organic anion transporter family member 1A5 Slco1a5 6600 nM Km
TKC109622 P46721 Solute carrier organic anion transporter family member 1A2 SLCO1A2 9 % Activity
TKC109622 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 30000 nM EC50
TKC109622 P26435 Sodium/bile acid cotransporter Slc10a1 14000 nM Km
TKC109622 Q12908 Ileal sodium/bile acid cotransporter SLC10A2 28000 nM Ki
TKC109622 Q14973 Sodium/bile acid cotransporter SLC10A1 8 % Activity
TKC109622 Q13822 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 ENPP2 10300 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q96RI1 NR1H4_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q96RI1 NR1H4_HUMAN Cholelithiasis [ICD-11: DC11]
Q96RI1 NR1H4_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
Q96RI1 NR1H4_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
Q96RI1 NR1H4_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96RI1 NR1H4_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q96RI1 NR1H4_HUMAN Chronic kidney disease [ICD-11: GB61]
Q96RI1 NR1H4_HUMAN Skeletal anomaly [ICD-11: LD24]
Q96RI1 NR1H4_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q96RI1 NR1H4_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q96RI1 NR1H4_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P04054 PA21B_HUMAN Leishmaniasis [ICD-11: 1F54]
P04054 PA21B_HUMAN Lichen planus [ICD-11: EA91]
P04054 PA21B_HUMAN Peroxisomal disease [ICD-11: 5C57]
P04054 PA21B_HUMAN Rosacea [ICD-11: ED90]
P04054 PA21B_HUMAN Synthesis disorder [ICD-11: 5C52-5C59]
P04054 PA21B_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P04054 PA21B_HUMAN Contact dermatitis [ICD-11: EK00-EK0Z]
P04054 PA21B_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P04054 PA21B_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P04054 PA21B_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
P04054 PA21B_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04054 PA21B_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P04054 PA21B_HUMAN Asthma [ICD-11: CA23]
P04054 PA21B_HUMAN Pruritus [ICD-11: EC90]
P04054 PA21B_HUMAN Unspecific body region injury [ICD-11: ND56]
P04054 PA21B_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
Q12908 NTCP2_HUMAN Gallbladder/bile ducts/liver structural developmental anomaly [ICD-11: LB20]
Q12908 NTCP2_HUMAN Inborn lipid metabolism error [ICD-11: 5C52]
Q12908 NTCP2_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]
Q12908 NTCP2_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q12908 NTCP2_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q12908 NTCP2_HUMAN Pruritus [ICD-11: EC90]
Q12908 NTCP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q14973 NTCP_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q14973 NTCP_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q14973 NTCP_HUMAN Gallbladder/bile ducts/liver structural developmental anomaly [ICD-11: LB20]
Q14973 NTCP_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]
Q13822 ENPP2_HUMAN Fibrosis [ICD-11: GA14-GC01]
Q13822 ENPP2_HUMAN Pain [ICD-11: MG30-MG3Z]
Q13822 ENPP2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q13822 ENPP2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]