Basic Information

Terpenoid ID TKC206671
Chirality TKC109622
Cell line 0
Protein target 10
DiseaseNCIT 0
ORDO 0
ICD 21

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC206671 MDA-N MDAN 100000.0 nM GI50 C3802
TKC206671 SN12C SN-12C 100000.0 nM GI50 C9385 Orphanet_217071
TKC206671 ACHN 100000.0 nM GI50 C6975 Orphanet_319298
TKC206671 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 100000.0 nM GI50 C3512
TKC206671 UO-31 UO.31; UO31; U031 100000.0 nM GI50 C9385 Orphanet_217071
TKC206671 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 100000.0 nM GI50 C2926
TKC206671 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 100000.0 nM GI50 C9154 Orphanet_519
TKC206671 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 100000.0 nM GI50 C4863
TKC206671 SF-539 SF-539; SF-539 BT; SF.539; SF 539 100000.0 nM GI50 C3796 Orphanet_251576
TKC206671 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 100000.0 nM GI50 C3510
TKC206671 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 100000.0 nM GI50 C3224
TKC206671 K562 K562; K.562; K 562; KO; GM05372; GM05372E 100000.0 nM GI50 C9110 Orphanet_521
TKC206671 A498 A498 100000.0 nM GI50 C9385 Orphanet_217071
TKC206671 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 100000.0 nM GI50 C105555
TKC206671 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 100000.0 nM GI50 C9142 Orphanet_99861
TKC206671 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 100000.0 nM GI50 C3512
TKC206671 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 45920.0 nM GI50 C105555
TKC206671 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 100000.0 nM GI50 C60781 Orphanet_94
TKC206671 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 100000.0 nM GI50 C105555
TKC206671 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 100000.0 nM GI50 C105555
TKC206671 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 100000.0 nM GI50 C60781 Orphanet_94
TKC206671 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 100000.0 nM GI50 C5214
TKC206671 SR SR-786; SR786 100000.0 nM GI50 C37193 Orphanet_300895
TKC206671 TK-10 TK.10; TK 10; TK10 100000.0 nM GI50 C4033 Orphanet_319276
TKC206671 SW-620 SW-620; SW 620; SW.620 100000.0 nM GI50 C4349
TKC206671 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 100000.0 nM GI50 C3512
TKC206671 KM12 KM-12; KM.12 100000.0 nM GI50 C4910
TKC206671 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 100000.0 nM GI50 C3802
TKC206671 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 100000.0 nM GI50 C2923
TKC206671 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 100000.0 nM GI50 C3242 Orphanet_29073
TKC206671 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 100000.0 nM GI50 C105555
TKC206671 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 100000.0 nM GI50 C3802
TKC206671 BT-549 BT 549; BT.549; BT549 100000.0 nM GI50 C4194
TKC206671 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 100000.0 nM GI50 C3224
TKC206671 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 100000.0 nM GI50 C4349
TKC206671 A549 100000.0 nM GI50 C3512
TKC206671 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 100000.0 nM GI50 C4910
TKC206671 HCT-15 HCT-15; HCT.15; HCT15 100000.0 nM GI50 C4349
TKC206671 EKVX 100000.0 nM GI50 C3512
TKC206671 SF-268 SF-268; SF.268; SF 268 100000.0 nM GI50 C60781 Orphanet_94
TKC206671 PC-3 PC3; PC.3 100000.0 nM GI50 C4863
TKC206671 MCF7 100000.0 nM GI50 C4194
TKC206671 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 100000.0 nM GI50 C7978
TKC206671 T47D 100000.0 nM GI50 C4194
TKC206671 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 100000.0 nM GI50 C4450
TKC206671 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 100000.0 nM GI50 C3224
TKC206671 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 100000.0 nM GI50 C3802
TKC206671 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 100000.0 nM GI50 C3224
TKC206671 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 100000.0 nM GI50 C7979 Orphanet_454723
TKC206671 SF-295 SF-295; SF.295; SF 295 100000.0 nM GI50 C3058 Orphanet_360
TKC206671 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 100000.0 nM GI50 C9385 Orphanet_217071
TKC206671 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 100000.0 nM GI50 C4194
TKC206671 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 100000.0 nM GI50 C3224
TKC206671 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 100000.0 nM GI50 C7953 Orphanet_99861
TKC206671 HT-29 HT 29; HT29 100000.0 nM GI50 C4349
TKC206671 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 100000.0 nM GI50 C45662 Orphanet_50251
TKC206671 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 100000.0 nM GI50 C3510
TKC206671 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 100000.0 nM GI50 C9385 Orphanet_217071
TKC206671 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 100000.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206671 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 82 % Inhibition
TKC206671 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 90 % Inhibition
TKC206671 P08183 ATP-dependent translocase ABCB1 ABCB1 66 % Activity
TKC206671 O15439 ATP-binding cassette sub-family C member 4 ABCC4 55000 nM IC50
TKC206671 O94956 Solute carrier organic anion transporter family member 2B1 SLCO2B1 47 % Inhibition
TKC206671 O95342 Bile salt export pump ABCB11 28000 nM Ki
TKC206671 Q96RI1 Bile acid receptor NR1H4 3000 nM EC50
TKC206671 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 7000 nM Km
TKC206671 O70127 Bile salt export pump Abcb11 2200 nM Km
TKC206671 O35913 Solute carrier organic anion transporter family member 1A4 Slco1a4 12000 nM Km
TKC206671 O88397 Solute carrier organic anion transporter family member 1A5 Slco1a5 7000 nM Km
TKC206671 P46721 Solute carrier organic anion transporter family member 1A2 SLCO1A2 17 % Activity
TKC206671 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 1920 nM EC50
TKC206671 Q9QY30 Bile salt export pump Abcb11 25 % Activity
TKC206671 P26435 Sodium/bile acid cotransporter Slc10a1 5000 nM Km
TKC206671 Q12908 Ileal sodium/bile acid cotransporter SLC10A2 6100 nM Ki
TKC206671 Q14973 Sodium/bile acid cotransporter SLC10A1 19 % Activity
TKC206671 Q6PSM0 Multidrug resistance protein 1a Mdr1a 33 % Activity
TKC206671 Q96QA9 ABC-type glutathione-S-conjugate transporter MRP3 6 % Activity

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08183 MDR1_HUMAN Lung cancer [ICD-11: 2C25]
P08183 MDR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08183 MDR1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P08183 MDR1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P08183 MDR1_HUMAN Adrenal cancer [ICD-11: 2D11]
P08183 MDR1_HUMAN Ovarian cancer [ICD-11: 2C73]
Q96RI1 NR1H4_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q96RI1 NR1H4_HUMAN Cholelithiasis [ICD-11: DC11]
Q96RI1 NR1H4_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
Q96RI1 NR1H4_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
Q96RI1 NR1H4_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96RI1 NR1H4_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q96RI1 NR1H4_HUMAN Chronic kidney disease [ICD-11: GB61]
Q96RI1 NR1H4_HUMAN Skeletal anomaly [ICD-11: LD24]
Q96RI1 NR1H4_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q96RI1 NR1H4_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q96RI1 NR1H4_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
Q12908 NTCP2_HUMAN Gallbladder/bile ducts/liver structural developmental anomaly [ICD-11: LB20]
Q12908 NTCP2_HUMAN Inborn lipid metabolism error [ICD-11: 5C52]
Q12908 NTCP2_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]
Q12908 NTCP2_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q12908 NTCP2_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q12908 NTCP2_HUMAN Pruritus [ICD-11: EC90]
Q12908 NTCP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q14973 NTCP_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q14973 NTCP_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q14973 NTCP_HUMAN Gallbladder/bile ducts/liver structural developmental anomaly [ICD-11: LB20]
Q14973 NTCP_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]