Basic Information

Terpenoid ID TKC071640
Chirality TKC050495
Cell line 0
Protein target 3
DiseaseNCIT 0
ORDO 0
ICD 4

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC071640 A549 10000.0 nM IC50 C3512
TKC071640 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 58000.0 nM IC50 C3802
TKC071640 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 42270.0 nM IC50 C27677
TKC071640 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 27520.0 nM IC50 C9154 Orphanet_519
TKC071640 HepG2 28050.0 nM IC50 C3728 Orphanet_449
TKC071640 A2780 A-2780; 2780; A2780S; A2780par 19900.0 nM EC50 C7979 Orphanet_454723
TKC071640 HT-29 HT 29; HT29 30000.0 nM EC50 C4349
TKC071640 MCF7 10000.0 nM IC50 C4194
TKC071640 8505C 8505c 30000.0 nM EC50 C3878 Orphanet_142
TKC071640 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 10000.0 nM IC50 C5214
TKC071640 MKN-45 MKN-45; MKN 45 53690.0 nM IC50 C4004
TKC071640 AGS 36140.0 nM IC50 C4004
TKC071640 BGC-823 BGC823 52070.0 nM IC50 C27677

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC071640 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 680 nM Ki
TKC071640 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 2110 nM Ki
TKC071640 P08183 ATP-dependent translocase ABCB1 ABCB1 100 % Survival
TKC071640 P00533 Epidermal growth factor receptor EGFR >20000 nM IC50
TKC071640 P35354 Prostaglandin G/H synthase 2 PTGS2 100 % Activity
TKC071640 O15296 Polyunsaturated fatty acid lipoxygenase ALOX15B ALOX15B >65 % Activity
TKC071640 P05979 Prostaglandin G/H synthase 1 PTGS1 100 % Activity
TKC071640 P09917 Polyunsaturated fatty acid 5-lipoxygenase ALOX5 >60 % Activity
TKC071640 P15559 NAD(P)H dehydrogenase [quinone] 1 NQO1 >20 ug ml-1 CD
TKC071640 P13726 Tissue factor F3 0 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08183 MDR1_HUMAN Lung cancer [ICD-11: 2C25]
P08183 MDR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08183 MDR1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P08183 MDR1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P08183 MDR1_HUMAN Adrenal cancer [ICD-11: 2D11]
P08183 MDR1_HUMAN Ovarian cancer [ICD-11: 2C73]
P00533 EGFR_HUMAN Non-small cell lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Head and neck cancer [ICD-11: 2D42]
P00533 EGFR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P00533 EGFR_HUMAN Angina pectoris [ICD-11: BA40]
P00533 EGFR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P00533 EGFR_HUMAN Colon cancer [ICD-11: 2B90]
P00533 EGFR_HUMAN Colorectal cancer [ICD-11: 2B91]
P00533 EGFR_HUMAN Diabetic foot ulcer [ICD-11: BD54]
P00533 EGFR_HUMAN Head and neck cancer [ICD-11: 2D42]
P00533 EGFR_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
P00533 EGFR_HUMAN Ischemia [ICD-11: 8B10-8B11]
P00533 EGFR_HUMAN Liver cancer [ICD-11: 2C12]
P00533 EGFR_HUMAN Lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Melanoma [ICD-11: 2C30]
P00533 EGFR_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P00533 EGFR_HUMAN Pancreatic cancer [ICD-11: 2C10]
P00533 EGFR_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P00533 EGFR_HUMAN Skin postprocedural disorder [ICD-11: EL8Y]
P00533 EGFR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P00533 EGFR_HUMAN Stomach cancer [ICD-11: 2B72]
P00533 EGFR_HUMAN Unspecific body region injury [ICD-11: ND56]
P00533 EGFR_HUMAN Urethral cancer [ICD-11: 2C93]
P00533 EGFR_HUMAN Brain cancer [ICD-11: 2A00]
P00533 EGFR_HUMAN Hypopharyngeal cancer [ICD-11: 2B6D]
P00533 EGFR_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P00533 EGFR_HUMAN Metastatic biliary tract neoplasms [ICD-11: 2C14-2C17]
P00533 EGFR_HUMAN Chronic pain [ICD-11: MG30]
P00533 EGFR_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P00533 EGFR_HUMAN Malignant mesenchymal neoplasm [ICD-11: 2B5D-2B5Y]
P00533 EGFR_HUMAN Non-small cell lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Intracerebral haemorrhage [ICD-11: 8B00]
P00533 EGFR_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P00533 EGFR_HUMAN Metastatic lymph node neoplasm [ICD-11: 2D60]
P00533 EGFR_HUMAN Spinal cord/cranial nerve neoplasm [ICD-11: 2A02]
P00533 EGFR_HUMAN Testicular cancer [ICD-11: 2C80]
P00533 EGFR_HUMAN Esophageal cancer [ICD-11: 2B70]
P00533 EGFR_HUMAN Psoriasis [ICD-11: EA90]
P00533 EGFR_HUMAN Digestive system disease [ICD-11: DE2Z]
P00533 EGFR_HUMAN Cerebral ischaemia [ICD-11: 8B1Z]
P00533 EGFR_HUMAN Cryptosporidiosis [ICD-11: 1A32]
P00533 EGFR_HUMAN Diffuse large B-cell lymphoma [ICD-11: 2A81]
P00533 EGFR_HUMAN Gram-positive bacterial infection [ICD-11: 1B74-1F40]
P00533 EGFR_HUMAN Brain cancer [ICD-11: 2A00]
P00533 EGFR_HUMAN Liver cancer [ICD-11: 2C12]
P00533 EGFR_HUMAN Lung cancer [ICD-11: 2C25]
P00533 EGFR_HUMAN Pancreatic cancer [ICD-11: 2C10]
P35354 PGH2_HUMAN Alzheimer disease [ICD-11: 8A20]
P35354 PGH2_HUMAN Chronic pain [ICD-11: MG30]
P35354 PGH2_HUMAN Endometriosis [ICD-11: GA10]
P35354 PGH2_HUMAN Female pelvic pain [ICD-11: GA34]
P35354 PGH2_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
P35354 PGH2_HUMAN Indeterminate colitis [ICD-11: DD72]
P35354 PGH2_HUMAN Knee osteoarthritis [ICD-11: FA01]
P35354 PGH2_HUMAN Migraine [ICD-11: 8A80]
P35354 PGH2_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
P35354 PGH2_HUMAN Pain [ICD-11: MG30-MG3Z]
P35354 PGH2_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P35354 PGH2_HUMAN Tuberculosis [ICD-11: 1B10-1B12]
P35354 PGH2_HUMAN Shoulder lesion [ICD-11: FB53]
P35354 PGH2_HUMAN Soft tissue disorder [ICD-11: FB56]
P35354 PGH2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P35354 PGH2_HUMAN Asthma [ICD-11: CA23]
P35354 PGH2_HUMAN Gout [ICD-11: FA25]
P35354 PGH2_HUMAN General pain disorder [ICD-11: 8E43]
P35354 PGH2_HUMAN Lupus erythematosus [ICD-11: 4A40]
P35354 PGH2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P35354 PGH2_HUMAN Large intestine polyp [ICD-11: DB35]
P35354 PGH2_HUMAN Lung cancer [ICD-11: 2C25]
P35354 PGH2_HUMAN Pancreatic cancer [ICD-11: 2C10]
P35354 PGH2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P35354 PGH2_HUMAN Colorectal cancer [ICD-11: 2B91]
P35354 PGH2_HUMAN Fever [ICD-11: MG26]
P35354 PGH2_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P09917 LOX5_HUMAN Asthma [ICD-11: CA23]
P09917 LOX5_HUMAN Filariasis [ICD-11: 1F66]
P09917 LOX5_HUMAN Thrombocytopenia [ICD-11: 3B64]
P09917 LOX5_HUMAN Lung cancer [ICD-11: 2C25]
P09917 LOX5_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P09917 LOX5_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P09917 LOX5_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P09917 LOX5_HUMAN Atopic eczema [ICD-11: EA80]
P09917 LOX5_HUMAN Carcinoid syndrome [ICD-11: 5B10]
P09917 LOX5_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
P09917 LOX5_HUMAN Idiopathic interstitial pneumonitis [ICD-11: CB03]
P09917 LOX5_HUMAN Influenza [ICD-11: 1E30-1E32]
P09917 LOX5_HUMAN Pituitary gland disorder [ICD-11: 5A60-5A61]
P09917 LOX5_HUMAN Psoriasis [ICD-11: EA90]
P09917 LOX5_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P09917 LOX5_HUMAN Pain [ICD-11: MG30-MG3Z]
P09917 LOX5_HUMAN Respiratory system disease [ICD-11: CB40-CB7Z]
P09917 LOX5_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P09917 LOX5_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P09917 LOX5_HUMAN Eczema [ICD-11: EA80-EA89]
P09917 LOX5_HUMAN Pruritus [ICD-11: EC90]
P09917 LOX5_HUMAN Thrombosis [ICD-11: DB61-GB90]
P09917 LOX5_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
P09917 LOX5_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P09917 LOX5_HUMAN Arterial occlusive disease [ICD-11: BD40]
P09917 LOX5_HUMAN Malaria [ICD-11: 1F40-1F45]
P09917 LOX5_HUMAN Asthma [ICD-11: CA23]
P09917 LOX5_HUMAN Pain [ICD-11: MG30-MG3Z]
P09917 LOX5_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P15559 NQO1_HUMAN Choreiform disorder [ICD-11: 8A01]
P15559 NQO1_HUMAN CNS anomalies syndrome [ICD-11: LD20]
P15559 NQO1_HUMAN Inborn energy metabolism error [ICD-11: 5C53]
P15559 NQO1_HUMAN Intellectual development disorder [ICD-11: LD90]
P15559 NQO1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P15559 NQO1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P13726 TF_HUMAN Acute respiratory distress syndrome [ICD-11: CB00]
P13726 TF_HUMAN Bleeding disorder [ICD-11: GA20-GA21]
P13726 TF_HUMAN Pancreatic cancer [ICD-11: 2C10]
P13726 TF_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]