Basic Information

Terpenoid ID TKC141164
Cell line 0
Protein target 1
DiseaseNCIT 0
ORDO 0
ICD 11

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC141164 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 8.0 ug ml-1 ED50 C3224
TKC141164 KB KB (HeLa derivative); HeLa-KB; Strain KB 12.0 ug ml-1 ED50 C27677
TKC141164 PC-3 PC3; PC.3 16711.0 nM GI50 C4863
TKC141164 K562 K562; K.562; K 562; KO; GM05372; GM05372E 20512.0 nM GI50 C9110 Orphanet_521
TKC141164 HT-29 HT 29; HT29 20464.0 nM GI50 C4349
TKC141164 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 19409.0 nM GI50 C7953 Orphanet_99861
TKC141164 B16 B-16; B16 melanoma; B16 subline B78; B78 4900.0 nM IC50 C21790
TKC141164 8505C 8505c 17170.0 nM IC50 C3878 Orphanet_142
TKC141164 A-431 A431; A431/P 26990.0 nM IC50 C4819
TKC141164 A549 17170.0 nM IC50 C3512
TKC141164 A2780 A-2780; 2780; A2780S; A2780par 16270.0 nM IC50 C7979 Orphanet_454723
TKC141164 DLD-1 DLD 1; DLD1; CoCL3 45860.0 nM IC50 C4349
TKC141164 FaDu FaDU; FADU 20330.0 nM IC50 C4043 Orphanet_494547
TKC141164 HCT-8 HCT-8; HCT8 17250.0 nM IC50 C4349
TKC141164 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 17418.0 nM GI50 C4910
TKC141164 MCF7 16930.0 nM IC50 C4194
TKC141164 SW480 SW-480; SW 480; SW480E 17920.0 nM IC50 C4349
TKC141164 SW-1736 SW-1736; SW 1736 32100.0 nM IC50 C3878 Orphanet_142
TKC141164 SN12C SN-12C 16106.0 nM GI50 C9385 Orphanet_217071
TKC141164 MDA-N MDAN 18155.0 nM GI50 C3802
TKC141164 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 30339.0 nM GI50 C3512
TKC141164 UO-31 UO.31; UO31; U031 22803.0 nM GI50 C9385 Orphanet_217071
TKC141164 ACHN 16943.0 nM GI50 C6975 Orphanet_319298
TKC141164 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 35481.0 nM GI50 C9154 Orphanet_519
TKC141164 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 19409.0 nM GI50 C2926
TKC141164 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 39811.0 nM GI50 C4863
TKC141164 SF-539 SF-539; SF-539 BT; SF.539; SF 539 13740.0 nM GI50 C3796 Orphanet_251576
TKC141164 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 18836.0 nM GI50 C3510
TKC141164 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 22491.0 nM GI50 C3224
TKC141164 A498 A498 18880.0 nM GI50 C9385 Orphanet_217071
TKC141164 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 19815.0 nM GI50 C105555
TKC141164 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 18793.0 nM GI50 C9142 Orphanet_99861
TKC141164 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 18836.0 nM GI50 C3512
TKC141164 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 17783.0 nM GI50 C60781 Orphanet_94
TKC141164 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 19011.0 nM GI50 C105555
TKC141164 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 26792.0 nM GI50 C105555
TKC141164 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 21528.0 nM GI50 C105555
TKC141164 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 18664.0 nM GI50 C60781 Orphanet_94
TKC141164 SR SR-786; SR786 32285.0 nM GI50 C37193 Orphanet_300895
TKC141164 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 34041.0 nM GI50 C5214
TKC141164 SW-620 SW-620; SW 620; SW.620 19634.0 nM GI50 C4349
TKC141164 TK-10 TK.10; TK 10; TK10 10000.0 nM GI50 C4033 Orphanet_319276
TKC141164 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 18923.0 nM GI50 C3512
TKC141164 KM12 KM-12; KM.12 15560.0 nM GI50 C4910
TKC141164 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 35400.0 nM GI50 C3802
TKC141164 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 19454.0 nM GI50 C2923
TKC141164 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 18365.0 nM GI50 C3802
TKC141164 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 21627.0 nM GI50 C3058 Orphanet_360
TKC141164 HCT-15 HCT-15; HCT.15; HCT15 20512.0 nM GI50 C4349
TKC141164 SF-268 SF-268; SF.268; SF 268 21429.0 nM GI50 C60781 Orphanet_94
TKC141164 EKVX 21677.0 nM GI50 C3512
TKC141164 T47D 11995.0 nM GI50 C4194
TKC141164 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 18493.0 nM GI50 C4450
TKC141164 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 20989.0 nM GI50 C3802
TKC141164 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 20797.0 nM GI50 C3224
TKC141164 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 18072.0 nM GI50 C7979 Orphanet_454723
TKC141164 SF-295 SF-295; SF.295; SF 295 18408.0 nM GI50 C3058 Orphanet_360
TKC141164 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 21627.0 nM GI50 C4194
TKC141164 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 19275.0 nM GI50 C3224
TKC141164 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 19724.0 nM GI50 C9385 Orphanet_217071
TKC141164 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 19953.0 nM GI50 C45662 Orphanet_50251
TKC141164 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 22336.0 nM GI50 C3510
TKC141164 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 14521.0 nM GI50 C9385 Orphanet_217071

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC141164 Q96RI1 Bile acid receptor NR1H4 0 nM EC50
TKC141164 P0DPI0 Botulinum neurotoxin type A botA <100000 nM IC50
TKC141164 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 >0 % Efficacy
TKC141164 P00921 Carbonic anhydrase 2 CA2 >50000 nM Ki

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q96RI1 NR1H4_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q96RI1 NR1H4_HUMAN Cholelithiasis [ICD-11: DC11]
Q96RI1 NR1H4_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
Q96RI1 NR1H4_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
Q96RI1 NR1H4_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96RI1 NR1H4_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q96RI1 NR1H4_HUMAN Chronic kidney disease [ICD-11: GB61]
Q96RI1 NR1H4_HUMAN Skeletal anomaly [ICD-11: LD24]
Q96RI1 NR1H4_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q96RI1 NR1H4_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q96RI1 NR1H4_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P0DPI0 BXA1_CLOBO Acne vulgaris [ICD-11: ED80]
P0DPI0 BXA1_CLOBO Ataxic disorder [ICD-11: 8A03]
P0DPI0 BXA1_CLOBO Clostridium difficile enterocolitis [ICD-11: 1A04]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]