Basic Information

Terpenoid ID TKC206849
Chirality TKC116861
Cell line 0
Protein target 28
DiseaseNCIT 0
ORDO 0
ICD 14

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC206849 Hepatocyte 21.0 pmol Drug uptake

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206849 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 96 % Inhibition
TKC206849 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 10000 nM Km
TKC206849 Q77YF9 Protein Vpr vpr 63096 nM Potency
TKC206849 P08183 ATP-dependent translocase ABCB1 ABCB1 88 % Activity
TKC206849 P0DTD1 Replicase polyprotein 1ab rep 11 % Inhibition
TKC206849 O15245 Solute carrier family 22 member 1 SLC22A1 -19 % Inhibition
TKC206849 O15439 ATP-binding cassette sub-family C member 4 ABCC4 250000 nM IC50
TKC206849 O15439 ATP-binding cassette sub-family C member 4 ABCC4 350000 nM IC50
TKC206849 O94956 Solute carrier organic anion transporter family member 2B1 SLCO2B1 96 % Inhibition
TKC206849 O95342 Bile salt export pump ABCB11 4250 nM Km
TKC206849 O95342 Bile salt export pump ABCB11 105 % Activity
TKC206849 Q92887 ATP-binding cassette sub-family C member 2 ABCC2 87 % Activity
TKC206849 P04054 Phospholipase A2 PLA2G1B 80 % Activity
TKC206849 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 32000 nM Ki
TKC206849 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 10800 nM Ki
TKC206849 Q9UNQ0 Broad substrate specificity ATP-binding cassette transporter ABCG2 ABCG2 70 % Activity
TKC206849 O70127 Bile salt export pump Abcb11 7500 nM Km
TKC206849 O35913 Solute carrier organic anion transporter family member 1A4 Slco1a4 39400 nM Ki
TKC206849 O35913 Solute carrier organic anion transporter family member 1A4 Slco1a4 1480000 nM IC50
TKC206849 O35913 Solute carrier organic anion transporter family member 1A4 Slco1a4 156000 nM Ki
TKC206849 O88397 Solute carrier organic anion transporter family member 1A5 Slco1a5 8800 nM Km
TKC206849 P46721 Solute carrier organic anion transporter family member 1A2 SLCO1A2 15900 nM Km
TKC206849 Q9QZX8 Solute carrier organic anion transporter family member 1B2 Slco1b2 9450 nM Km
TKC206849 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 4950 nM EC50
TKC206849 P33527 Multidrug resistance-associated protein 1 ABCC1 72 % Activity
TKC206849 P70502 Solute carrier organic anion transporter family member 1A3 Slco1a3 183000 nM Ki
TKC206849 Q9JHI3 Solute carrier organic anion transporter family member 2B1 Slco2b1 17600 nM Km
TKC206849 Q9QXZ6 Solute carrier organic anion transporter family member 1A1 Slco1a1 12000 nM Km
TKC206849 Q9QY30 Bile salt export pump Abcb11 11000 nM Km
TKC206849 Q9R1U7 Solute carrier family 22 member 8 Slc22a8 790000 nM Ki
TKC206849 O08705 Sodium/bile acid cotransporter Slc10a1 18000 nM Km
TKC206849 P26435 Sodium/bile acid cotransporter Slc10a1 6000 nM IC50
TKC206849 P70172 Ileal sodium/bile acid cotransporter Slc10a2 13000 nM Km
TKC206849 Q12908 Ileal sodium/bile acid cotransporter SLC10A2 41500 nM Ki
TKC206849 Q14973 Sodium/bile acid cotransporter SLC10A1 5300 nM IC50
TKC206849 Q62633 Ileal sodium/bile acid cotransporter Slc10a2 35000 nM Km
TKC206849 Q5T3U5 ATP-binding cassette sub-family C member 10 ABCC10 45 % Activity
TKC206849 Q96J66 ATP-binding cassette sub-family C member 11 ABCC11 72 % Activity
TKC206849 Q96QA9 ABC-type glutathione-S-conjugate transporter MRP3 40000 nM IC50
TKC206849 O88563 ATP-binding cassette sub-family C member 3 Abcc3 15900 nM Km
TKC206849 O35956 Solute carrier family 22 member 6 Slc22a6 2770000 nM Ki
TKC206849 O88909 Solute carrier family 22 member 8 Slc22a8 20 % Activity
TKC206849 Q95KY9 Solute carrier organic anion transporter family member SLCO1A2 40200 nM Km
TKC206849 Q96BD0 Solute carrier organic anion transporter family member 4A1 SLCO4A1 14900 nM Km
TKC206849 Q9ERB5 Solute carrier organic anion transporter family member 1C1 Slco1c1 109000 nM Ki
TKC206849 Q9UIG8 Solute carrier organic anion transporter family member 3A1 SLCO3A1 40 % Activity

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08183 MDR1_HUMAN Lung cancer [ICD-11: 2C25]
P08183 MDR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08183 MDR1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P08183 MDR1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P08183 MDR1_HUMAN Adrenal cancer [ICD-11: 2D11]
P08183 MDR1_HUMAN Ovarian cancer [ICD-11: 2C73]
P04054 PA21B_HUMAN Leishmaniasis [ICD-11: 1F54]
P04054 PA21B_HUMAN Lichen planus [ICD-11: EA91]
P04054 PA21B_HUMAN Peroxisomal disease [ICD-11: 5C57]
P04054 PA21B_HUMAN Rosacea [ICD-11: ED90]
P04054 PA21B_HUMAN Synthesis disorder [ICD-11: 5C52-5C59]
P04054 PA21B_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P04054 PA21B_HUMAN Contact dermatitis [ICD-11: EK00-EK0Z]
P04054 PA21B_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P04054 PA21B_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P04054 PA21B_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
P04054 PA21B_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04054 PA21B_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P04054 PA21B_HUMAN Asthma [ICD-11: CA23]
P04054 PA21B_HUMAN Pruritus [ICD-11: EC90]
P04054 PA21B_HUMAN Unspecific body region injury [ICD-11: ND56]
P04054 PA21B_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q9UNQ0 ABCG2_HUMAN Irritable bowel syndrome [ICD-11: DD91]
Q9UNQ0 ABCG2_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P33527 MRP1_HUMAN Gout [ICD-11: FA25]
Q12908 NTCP2_HUMAN Gallbladder/bile ducts/liver structural developmental anomaly [ICD-11: LB20]
Q12908 NTCP2_HUMAN Inborn lipid metabolism error [ICD-11: 5C52]
Q12908 NTCP2_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]
Q12908 NTCP2_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q12908 NTCP2_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q12908 NTCP2_HUMAN Pruritus [ICD-11: EC90]
Q12908 NTCP2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q14973 NTCP_HUMAN Hepatitis virus infection [ICD-11: 1E50-1E51]
Q14973 NTCP_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q14973 NTCP_HUMAN Gallbladder/bile ducts/liver structural developmental anomaly [ICD-11: LB20]
Q14973 NTCP_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]