Basic Information

Terpenoid ID TKC112826
Cell line 0
Protein target 12
DiseaseNCIT 0
ORDO 0
ICD 14

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC112826 HT-29 HT 29; HT29 25700.0 nM IC50 C4349
TKC112826 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 75000.0 nM IC50
TKC112826 C6 C-6; C 6; RGC-6; RGC6; RGc6 20000.0 nM IC50 C64069
TKC112826 U-937 U937; U 937 2.0 % Activity C8263 Orphanet_514

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC112826 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 16360 nM Potency
TKC112826 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 91 % Inhibition
TKC112826 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 97 % Inhibition
TKC112826 O95398 Rap guanine nucleotide exchange factor 3 RAPGEF3 100000 nM Potency
TKC112826 P53350 Serine/threonine-protein kinase PLK1 PLK1 33588 nM Potency
TKC112826 Q9UNA4 DNA polymerase iota POLI 89125 nM Potency
TKC112826 O75496 Geminin GMNN 146 nM Potency
TKC112826 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 10000 nM Potency
TKC112826 O00255 Menin MEN1 3981 nM Potency
TKC112826 P02791 Ferritin light chain FTL 39811 nM Potency
TKC112826 P16050 Polyunsaturated fatty acid lipoxygenase ALOX15 ALOX15 31623 nM Potency
TKC112826 O75604 Ubiquitin carboxyl-terminal hydrolase 2 USP2 3981 nM Potency
TKC112826 P35398 Nuclear receptor ROR-alpha RORA 12 nM Ki
TKC112826 Q9UHC9 NPC1-like intracellular cholesterol transporter 1 NPC1L1 8700 nM EC50
TKC112826 Q9Y6A2 Cholesterol 24-hydroxylase CYP46A1 53 % Activity

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O95398 RPGF3_HUMAN Epidermal dysplasias [ICD-11: EK90]
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75604 UBP2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P35398 RORA_HUMAN Liver cancer [ICD-11: 2C12]
P35398 RORA_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q9UHC9 NPCL1_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q9Y6A2 CP46A_HUMAN Acidosis [ICD-11: 5C73]
Q9Y6A2 CP46A_HUMAN Epilepsy/seizure [ICD-11: 8A61-8A6Z]
Q9Y6A2 CP46A_HUMAN Epileptic encephalopathy [ICD-11: 8A62]
Q9Y6A2 CP46A_HUMAN Phakomatoses/hamartoneoplastic syndrome [ICD-11: LD2D]
Q9Y6A2 CP46A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]