Basic Information

Terpenoid ID TKC008359
Chirality TKC008361
Cell line 0
Protein target 14
DiseaseNCIT 0
ORDO 0
ICD 30

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC008359 XF498 XF-498; XF498 73621.0 nM GI50 C3058 Orphanet_360
TKC008359 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 15.0 ug.mL-1 CC50 C27677
TKC008359 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 53.0 ug.mL-1 CC50
TKC008359 SN12C SN-12C 62373.0 nM GI50 C9385 Orphanet_217071
TKC008359 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 45290.0 nM GI50 C3512
TKC008359 ACHN 53827.0 nM GI50 C6975 Orphanet_319298
TKC008359 UO-31 UO.31; UO31; U031 43652.0 nM GI50 C9385 Orphanet_217071
TKC008359 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 37239.0 nM GI50 C2926
TKC008359 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 50466.0 nM GI50 C9154 Orphanet_519
TKC008359 SF-539 SF-539; SF-539 BT; SF.539; SF 539 70795.0 nM GI50 C3796 Orphanet_251576
TKC008359 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 60534.0 nM GI50 C3510
TKC008359 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 66988.0 nM GI50 C3224
TKC008359 K562 K562; K.562; K 562; KO; GM05372; GM05372E 52966.0 nM GI50 C9110 Orphanet_521
TKC008359 A498 A498 49774.0 nM GI50 C9385 Orphanet_217071
TKC008359 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 35727.0 nM GI50 C105555
TKC008359 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 40179.0 nM GI50 C9142 Orphanet_99861
TKC008359 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 67764.0 nM GI50 C3512
TKC008359 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 50119.0 nM GI50 C60781 Orphanet_94
TKC008359 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 56885.0 nM GI50 C105555
TKC008359 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 75509.0 nM GI50 C105555
TKC008359 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 67143.0 nM GI50 C60781 Orphanet_94
TKC008359 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 48084.0 nM GI50 C4917 Orphanet_70573
TKC008359 TK-10 TK.10; TK 10; TK10 66374.0 nM GI50 C4033 Orphanet_319276
TKC008359 SR SR-786; SR786 100000.0 nM GI50 C37193 Orphanet_300895
TKC008359 M19-MEL M-19; M19 59020.0 nM GI50 C3802
TKC008359 SW-620 SW-620; SW 620; SW.620 45814.0 nM GI50 C4349
TKC008359 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 45709.0 nM GI50 C3512
TKC008359 KM12 KM-12; KM.12 37844.0 nM GI50 C4910
TKC008359 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 67920.0 nM GI50 C3802
TKC008359 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 65313.0 nM GI50 C2923
TKC008359 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 46559.0 nM GI50 C3242 Orphanet_29073
TKC008359 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 58614.0 nM GI50 C3802
TKC008359 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 59566.0 nM GI50 C105555
TKC008359 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 50933.0 nM GI50 C3224
TKC008359 KM-20L2 KM-20L2; KM 20L2; KM 2012 63241.0 nM GI50 C4349
TKC008359 A549 100000.0 nM IC50 C3512
TKC008359 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 55847.0 nM GI50 C3058 Orphanet_360
TKC008359 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 79983.0 nM GI50 C4349
TKC008359 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 45082.0 nM GI50 C4910
TKC008359 HCT-15 HCT-15; HCT.15; HCT15 43351.0 nM GI50 C4349
TKC008359 SF-268 SF-268; SF.268; SF 268 69024.0 nM GI50 C60781 Orphanet_94
TKC008359 EKVX 42560.0 nM GI50 C3512
TKC008359 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 64269.0 nM GI50 C2926
TKC008359 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 58884.0 nM GI50 C4917 Orphanet_70573
TKC008359 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 90400.0 nM IC50 C7978
TKC008359 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 36308.0 nM GI50 C3224
TKC008359 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 46989.0 nM GI50 C4450
TKC008359 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 36224.0 nM GI50 C3224
TKC008359 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 57544.0 nM GI50 C7979 Orphanet_454723
TKC008359 SF-295 SF-295; SF.295; SF 295 37844.0 nM GI50 C3058 Orphanet_360
TKC008359 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 62806.0 nM GI50 C9385 Orphanet_217071
TKC008359 SNB-78 SNB78; Surgical Neurology Branch-78 59704.0 nM GI50 C3058 Orphanet_360
TKC008359 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 56105.0 nM GI50 C3224
TKC008359 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 42855.0 nM GI50 C7953 Orphanet_99861
TKC008359 DLD-1 DLD 1; DLD1; CoCL3 67920.0 nM GI50 C4349
TKC008359 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 49204.0 nM GI50 C45662 Orphanet_50251
TKC008359 HT-29 HT 29; HT29 30061.0 nM GI50 C4349
TKC008359 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 59293.0 nM GI50 C3510
TKC008359 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 40272.0 nM GI50 C4349
TKC008359 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 62087.0 nM GI50 C9385 Orphanet_217071
TKC008359 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 74989.0 nM GI50 C4450

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC008359 P10636 Microtubule-associated protein tau MAPT 17783 nM Potency
TKC008359 P11473 Vitamin D3 receptor VDR 28184 nM Potency
TKC008359 P08684 Cytochrome P450 3A4 CYP3A4 39811 nM Potency
TKC008359 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 4080 nM Ki
TKC008359 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 1470 nM Ki
TKC008359 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 79433 nM Potency
TKC008359 P35354 Prostaglandin G/H synthase 2 PTGS2 <30 % Inhibition
TKC008359 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 19953 nM Potency
TKC008359 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 39811 nM Potency
TKC008359 P16050 Polyunsaturated fatty acid lipoxygenase ALOX15 ALOX15 2512 nM Potency
TKC008359 P51450 Nuclear receptor ROR-gamma Rorc 17783 nM Potency
TKC008359 O94925 Glutaminase kidney isoform, mitochondrial GLS 14125 nM Potency
TKC008359 P02545 Prelamin-A/C LMNA 1995 nM Potency
TKC008359 P0C6X7 Replicase polyprotein 1ab rep 189100 nM IC50
TKC008359 P0C6X7 Replicase polyprotein 1ab rep 189100 nM IC50
TKC008359 Q15119 Pyruvate dehydrogenase PDK2 20000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P35354 PGH2_HUMAN Alzheimer disease [ICD-11: 8A20]
P35354 PGH2_HUMAN Chronic pain [ICD-11: MG30]
P35354 PGH2_HUMAN Endometriosis [ICD-11: GA10]
P35354 PGH2_HUMAN Female pelvic pain [ICD-11: GA34]
P35354 PGH2_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
P35354 PGH2_HUMAN Indeterminate colitis [ICD-11: DD72]
P35354 PGH2_HUMAN Knee osteoarthritis [ICD-11: FA01]
P35354 PGH2_HUMAN Migraine [ICD-11: 8A80]
P35354 PGH2_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
P35354 PGH2_HUMAN Pain [ICD-11: MG30-MG3Z]
P35354 PGH2_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P35354 PGH2_HUMAN Tuberculosis [ICD-11: 1B10-1B12]
P35354 PGH2_HUMAN Shoulder lesion [ICD-11: FB53]
P35354 PGH2_HUMAN Soft tissue disorder [ICD-11: FB56]
P35354 PGH2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P35354 PGH2_HUMAN Asthma [ICD-11: CA23]
P35354 PGH2_HUMAN Gout [ICD-11: FA25]
P35354 PGH2_HUMAN General pain disorder [ICD-11: 8E43]
P35354 PGH2_HUMAN Lupus erythematosus [ICD-11: 4A40]
P35354 PGH2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P35354 PGH2_HUMAN Large intestine polyp [ICD-11: DB35]
P35354 PGH2_HUMAN Lung cancer [ICD-11: 2C25]
P35354 PGH2_HUMAN Pancreatic cancer [ICD-11: 2C10]
P35354 PGH2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P35354 PGH2_HUMAN Colorectal cancer [ICD-11: 2B91]
P35354 PGH2_HUMAN Fever [ICD-11: MG26]
P35354 PGH2_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q15119 PDK2_HUMAN Acute diabete complication [ICD-11: 5A2Y]