Basic Information

Terpenoid ID TKC053930
Cell line 0
Protein target 11
DiseaseNCIT 0
ORDO 0
ICD 14

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC053930 HepG2 15.0 % Protection C3728 Orphanet_449
TKC053930 Hepatocyte 24.0 % Activity
TKC053930 ECV-304 ECV 304; ECV304; ECV; E304; T24(ECV304) 119000.0 nM IC50 C4912
TKC053930 MDCK MDCK (NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney 15200.0 nM EC50

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC053930 P18031 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 >100000 nM IC50
TKC053930 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 12500 nM Ki
TKC053930 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 15900 nM Ki
TKC053930 Q9UBT6 DNA polymerase kappa POLK 31623 nM Potency
TKC053930 P25779 Cruzipain 3162 nM Potency
TKC053930 P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 6 nM IC50
TKC053930 P04798 Cytochrome P450 1A1 CYP1A1 39 % Inhibition
TKC053930 Q16678 Cytochrome P450 1B1 CYP1B1 11 % Inhibition
TKC053930 P50172 Corticosteroid 11-beta-dehydrogenase isozyme 1 Hsd11b1 3 nM IC50
TKC053930 O94956 Solute carrier organic anion transporter family member 2B1 SLCO2B1 29 % Inhibition
TKC053930 Q92887 ATP-binding cassette sub-family C member 2 ABCC2 5 % Activity
TKC053930 P00690 Pancreatic alpha-amylase AMY2 >200000 nM IC50
TKC053930 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 52 % Activity
TKC053930 P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0 nM IC50
TKC053930 P00489 Glycogen phosphorylase, muscle form PYGM 822000 nM IC50
TKC053930 Q63120 ATP-binding cassette sub-family C member 2 Abcc2 1910 nM Ki
TKC053930 O35913 Solute carrier organic anion transporter family member 1A4 Slco1a4 47 % Activity
TKC053930 O88397 Solute carrier organic anion transporter family member 1A5 Slco1a5 51 % Activity
TKC053930 P09429 High mobility group protein B1 HMGB1 87000 nM Kd
TKC053930 P63158 High mobility group protein B1 Hmgb1 70 uM ED50
TKC053930 Q9QZX8 Solute carrier organic anion transporter family member 1B2 Slco1b2 6100 nM Ki

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P18031 PTN1_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P18031 PTN1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P18031 PTN1_HUMAN Obesity [ICD-11: 5B80-5B81]
P18031 PTN1_HUMAN Ophthalmic devices/implants/grafts injury [ICD-11: PK97]
P18031 PTN1_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P18031 PTN1_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P25779 CYSP_TRYCR Parasitic worm infestation [ICD-11: 1F90]
P25779 CYSP_TRYCR Malaria [ICD-11: 1F40-1F45]
P28845 DHI1_HUMAN Influenza [ICD-11: 1E30-1E32]
P28845 DHI1_HUMAN Lupus erythematosus [ICD-11: 4A40]
P28845 DHI1_HUMAN Myasthenia gravis [ICD-11: 8C6Y]
P28845 DHI1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P28845 DHI1_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P28845 DHI1_HUMAN Alzheimer disease [ICD-11: 8A20]
P28845 DHI1_HUMAN Glaucoma [ICD-11: 9C61]
P28845 DHI1_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
P28845 DHI1_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P28845 DHI1_HUMAN Inborn lipid metabolism error [ICD-11: 5C52]
P28845 DHI1_HUMAN Obesity [ICD-11: 5B80-5B81]
P80365 DHI2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]