Basic Information
| Terpenoid ID | TKC074866 |
|
| Chirality | TKC019374 | |
| Cell line | 0 | |
| Protein target | 9 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 63 |
| Terpenoid ID | TKC074866 |
|
| Chirality | TKC019374 | |
| Cell line | 0 | |
| Protein target | 9 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 63 |
| ID | Cell Line | Synonyms | Value | Unit | Type | NCIt | ORDO |
|---|---|---|---|---|---|---|---|
| TKC074866 | COLO 205 | Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 | 100000.0 | nM | GI50 | C4349 | |
| TKC074866 | PC-3 | PC3; PC.3 | 10.0 | % | Activity | C4863 | |
| TKC074866 | SK-MEL-28 | SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 | 100000.0 | nM | GI50 | C3510 | |
| TKC074866 | SN12C | SN-12C | 100000.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC074866 | MDA-N | MDAN | 100000.0 | nM | GI50 | C3802 | |
| TKC074866 | ACHN | 100000.0 | nM | GI50 | C6975 | Orphanet_319298 | |
| TKC074866 | NCI-H23 | NCI.H23; NCI H23; H-23; H23; NCIH23 | 100000.0 | nM | GI50 | C3512 | |
| TKC074866 | UO-31 | UO.31; UO31; U031 | 100000.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC074866 | DU-145 | DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 | 100000.0 | nM | GI50 | C4863 | |
| TKC074866 | SK-MEL-5 | SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel | 100000.0 | nM | GI50 | C3510 | |
| TKC074866 | SF-539 | SF-539; SF-539 BT; SF.539; SF 539 | 100000.0 | nM | GI50 | C3796 | Orphanet_251576 |
| TKC074866 | Malme-3M | MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer | 100000.0 | nM | GI50 | C3224 | |
| TKC074866 | K562 | K562; K.562; K 562; KO; GM05372; GM05372E | 100000.0 | nM | GI50 | C9110 | Orphanet_521 |
| TKC074866 | A498 | A498 | 100000.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC074866 | OVCAR-3 | Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 | 100000.0 | nM | GI50 | C105555 | |
| TKC074866 | MOLT-4 | Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D | 100000.0 | nM | GI50 | C9142 | Orphanet_99861 |
| TKC074866 | HOP-62 | HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 | 100000.0 | nM | GI50 | C3512 | |
| TKC074866 | NCI/ADR-RES | NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR | 100000.0 | nM | GI50 | C105555 | |
| TKC074866 | OVCAR-8 | OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 | 100000.0 | nM | GI50 | C105555 | |
| TKC074866 | U-251 | U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) | 100000.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC074866 | OVCAR-5 | OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 | 100000.0 | nM | GI50 | C105555 | |
| TKC074866 | SNB-19 | SNB.19; SNB19; Surgical Neurology Branch-19 | 100000.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC074866 | MDA-MB-231 | MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 | 100000.0 | nM | GI50 | C5214 | |
| TKC074866 | TK-10 | TK.10; TK 10; TK10 | 100000.0 | nM | GI50 | C4033 | Orphanet_319276 |
| TKC074866 | SW-620 | SW-620; SW 620; SW.620 | 100000.0 | nM | GI50 | C4349 | |
| TKC074866 | KM12 | KM-12; KM.12 | 100000.0 | nM | GI50 | C4910 | |
| TKC074866 | NCI-H522 | NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 | 100000.0 | nM | GI50 | C3512 | |
| TKC074866 | M14 | M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 | 100000.0 | nM | GI50 | C3802 | |
| TKC074866 | NCI-H322M | NCI.H322M; H322M; H-322M; H-322m | 100000.0 | nM | GI50 | C2923 | |
| TKC074866 | RPMI-8226 | RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson | 100000.0 | nM | GI50 | C3242 | Orphanet_29073 |
| TKC074866 | OVCAR-4 | OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 | 100000.0 | nM | GI50 | C105555 | |
| TKC074866 | LOX IMVI | LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX | 100000.0 | nM | GI50 | C3802 | |
| TKC074866 | BT-549 | BT 549; BT.549; BT549 | 100000.0 | nM | GI50 | C4194 | |
| TKC074866 | SK-MEL-2 | SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 | 100000.0 | nM | GI50 | C3224 | |
| TKC074866 | HCC 2998 | HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 | 100000.0 | nM | GI50 | C4349 | |
| TKC074866 | A549 | 100000.0 | nM | GI50 | C3512 | ||
| TKC074866 | HCT-116 | HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 | 100000.0 | nM | GI50 | C4910 | |
| TKC074866 | HCT-15 | HCT-15; HCT.15; HCT15 | 100000.0 | nM | GI50 | C4349 | |
| TKC074866 | EKVX | 100000.0 | nM | GI50 | C3512 | ||
| TKC074866 | SF-268 | SF-268; SF.268; SF 268 | 100000.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC074866 | MCF7 | 100000.0 | nM | GI50 | C4194 | ||
| TKC074866 | SK-OV-3 | SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 | 100000.0 | nM | GI50 | C7978 | |
| TKC074866 | T47D | 100000.0 | nM | GI50 | C4194 | ||
| TKC074866 | NCI-H460 | NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 | 100000.0 | nM | GI50 | C4450 | |
| TKC074866 | UACC-62 | UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 | 100000.0 | nM | GI50 | C3224 | |
| TKC074866 | CAKI-1 | CAL 1; Centre Antoine Lacassagne-1 | 100000.0 | nM | GI50 | C3224 | |
| TKC074866 | MDA-MB-435 | MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 | 100000.0 | nM | GI50 | C3802 | |
| TKC074866 | SF-295 | SF-295; SF.295; SF 295 | 100000.0 | nM | GI50 | C3058 | Orphanet_360 |
| TKC074866 | IGROV-1 | Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P | 100000.0 | nM | GI50 | C7979 | Orphanet_454723 |
| TKC074866 | Hs-578T | HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells | 100000.0 | nM | GI50 | C4194 | |
| TKC074866 | 786-0 | 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT | 100000.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC074866 | UACC-257 | UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 | 100000.0 | nM | GI50 | C3224 | |
| TKC074866 | CCRF-CEM | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C | 100000.0 | nM | GI50 | C7953 | Orphanet_99861 |
| TKC074866 | HT-29 | HT 29; HT29 | 100000.0 | nM | GI50 | C4349 | |
| TKC074866 | NCI-H226 | NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 | 100000.0 | nM | GI50 | C45662 | Orphanet_50251 |
| TKC074866 | PANC-1 | Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P | 20.0 | % | Activity | C9120 |
| ID | Uniport | Pref_name | Gene name | value | unit | type |
|---|---|---|---|---|---|---|
| TKC074866 | P11473 | Vitamin D3 receptor | VDR | 1 | nM | Potency |
| TKC074866 | P08684 | Cytochrome P450 3A4 | CYP3A4 | 15849 | nM | Potency |
| TKC074866 | O42275 | Acetylcholinesterase | ache | 100000 | nM | Ki |
| TKC074866 | P04150 | Glucocorticoid receptor | NR3C1 | 25119 | nM | Potency |
| TKC074866 | O00255 | Menin | MEN1 | 3981 | nM | Potency |
| TKC074866 | P25779 | Cruzipain | 39811 | nM | Potency | |
| TKC074866 | Q8NHB7 | Olfactory receptor 5K1 | OR5K1 | >40 | % | Inhibition |
| TKC074866 | P16050 | Polyunsaturated fatty acid lipoxygenase ALOX15 | ALOX15 | 7943 | nM | Potency |
| TKC074866 | Q03181 | Peroxisome proliferator-activated receptor delta | PPARD | 1 | nM | Potency |
| TKC074866 | Q8MK44 | Diacylglycerol O-acyltransferase 1 | DGAT1 | 13 | % | Inhibition |
| TKC074866 | Q8NER1 | Transient receptor potential cation channel subfamily V member 1 | TRPV1 | >102 | uM | Activity |
| TKC074866 | P0DTE4 | UDP-glucuronosyltransferase 2A1 | UGT2A1 | 337 | pm/min/mg | Activity |
| TKC074866 | Q6RI86 | Transient receptor potential cation channel subfamily A member 1 | Trpa1 | >100000 | nM | IC50 |
| TKC074866 | Q8R455 | Transient receptor potential cation channel subfamily M member 8 | Trpm8 | >100000 | nM | IC50 |
| TKC074866 | Q7Z2W7 | Transient receptor potential cation channel subfamily M member 8 | TRPM8 | 5900000 | nM | EC50 |
| Uniport ID | Uniport Name | ICD-11 |
|---|---|---|
| P11473 | VDR_HUMAN | Chronic kidney disease [ICD-11: GB61] |
| P11473 | VDR_HUMAN | Hair/hair growth developmental defect [ICD-11: LC30] |
| P11473 | VDR_HUMAN | Hyper-parathyroidism [ICD-11: 5A51] |
| P11473 | VDR_HUMAN | Hypo-parathyroidism [ICD-11: 5A50] |
| P11473 | VDR_HUMAN | Mineral deficiency [ICD-11: 5B5K] |
| P11473 | VDR_HUMAN | Psoriasis [ICD-11: EA90] |
| P11473 | VDR_HUMAN | Vitamin deficiency [ICD-11: 5B55-5B5F] |
| P11473 | VDR_HUMAN | Low bone mass disorder [ICD-11: FB83] |
| P11473 | VDR_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| P11473 | VDR_HUMAN | Prostate cancer [ICD-11: 2C82] |
| P11473 | VDR_HUMAN | Prostate disease [ICD-11: GA91] |
| P11473 | VDR_HUMAN | Abnormal micturition [ICD-11: MF50] |
| P11473 | VDR_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P11473 | VDR_HUMAN | Postoperative inflammation [ICD-11: 1A00-CA43] |
| P11473 | VDR_HUMAN | Acne vulgaris [ICD-11: ED80] |
| P08684 | CP3A4_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P08684 | CP3A4_HUMAN | Atopic eczema [ICD-11: EA80] |
| P08684 | CP3A4_HUMAN | Anxiety disorder [ICD-11: 6B00-6B0Z] |
| P04150 | GCR_HUMAN | Acute diabete complication [ICD-11: 5A2Y] |
| P04150 | GCR_HUMAN | Indeterminate colitis [ICD-11: DD72] |
| P04150 | GCR_HUMAN | Multiple sclerosis [ICD-11: 8A40] |
| P04150 | GCR_HUMAN | Muscular dystrophy [ICD-11: 8C70] |
| P04150 | GCR_HUMAN | Prostate cancer [ICD-11: 2C82] |
| P04150 | GCR_HUMAN | Rheumatoid arthritis [ICD-11: FA20] |
| P04150 | GCR_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| P04150 | GCR_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P04150 | GCR_HUMAN | Adaptive immunity immunodeficiency [ICD-11: 4A01] |
| P04150 | GCR_HUMAN | Adrenogenital disorder [ICD-11: 5A71] |
| P04150 | GCR_HUMAN | Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z] |
| P04150 | GCR_HUMAN | Asthma [ICD-11: CA23] |
| P04150 | GCR_HUMAN | Atopic eczema [ICD-11: EA80] |
| P04150 | GCR_HUMAN | Chronic obstructive pulmonary disease [ICD-11: CA22] |
| P04150 | GCR_HUMAN | Cushing syndrome [ICD-11: 5A70] |
| P04150 | GCR_HUMAN | Eczema [ICD-11: EA80-EA89] |
| P04150 | GCR_HUMAN | Multiple sclerosis [ICD-11: 8A40] |
| P04150 | GCR_HUMAN | Muscular dystrophy [ICD-11: 8C70] |
| P04150 | GCR_HUMAN | Oesophagitis [ICD-11: DA24] |
| P04150 | GCR_HUMAN | Postoperative inflammation [ICD-11: 1A00-CA43] |
| P04150 | GCR_HUMAN | Rheumatoid arthritis [ICD-11: FA20] |
| P04150 | GCR_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P04150 | GCR_HUMAN | Spine/trunk injury [ICD-11: ND51] |
| P04150 | GCR_HUMAN | Vasomotor/allergic rhinitis [ICD-11: CA08] |
| P04150 | GCR_HUMAN | Herpes simplex infection [ICD-11: 1F00] |
| P04150 | GCR_HUMAN | Otitis externa [ICD-11: AA00-AA13] |
| P04150 | GCR_HUMAN | Substance abuse [ICD-11: 6C40] |
| P04150 | GCR_HUMAN | Breast cancer [ICD-11: 2C60-2C6Y] |
| P04150 | GCR_HUMAN | Depression [ICD-11: 6A70-6A7Z] |
| P04150 | GCR_HUMAN | Mood disorder [ICD-11: 6A60-6E23] |
| P04150 | GCR_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| P04150 | GCR_HUMAN | Vitamin deficiency [ICD-11: 5B55-5B5F] |
| P04150 | GCR_HUMAN | Retinopathy [ICD-11: 9B71] |
| P04150 | GCR_HUMAN | Anxiety disorder [ICD-11: 6B00-6B0Z] |
| P25779 | CYSP_TRYCR | Parasitic worm infestation [ICD-11: 1F90] |
| P25779 | CYSP_TRYCR | Malaria [ICD-11: 1F40-1F45] |
| Q03181 | PPARD_HUMAN | Non-alcoholic fatty liver disease [ICD-11: DB92] |
| Q03181 | PPARD_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| Q03181 | PPARD_HUMAN | Autoimmune liver disease [ICD-11: DB96] |
| Q03181 | PPARD_HUMAN | Hyper-lipoproteinaemia [ICD-11: 5C80] |
| Q03181 | PPARD_HUMAN | Obesity [ICD-11: 5B80-5B81] |
| Q03181 | PPARD_HUMAN | Alzheimer disease [ICD-11: 8A20] |
| Q03181 | PPARD_HUMAN | Dyslipidemia [ICD-11: 5C80-5C81] |
| Q03181 | PPARD_HUMAN | Metabolic disorder [ICD-11: 5C50-5D2Z] |
| Q03181 | PPARD_HUMAN | Diabetes mellitus [ICD-11: 5A10] |
| Q03181 | PPARD_HUMAN | Central nervous system disease [ICD-11: 8A04-8D87] |
| Q8NER1 | TRPV1_HUMAN | Visual system disease [ICD-11: 9E1Z] |
| Q8NER1 | TRPV1_HUMAN | General pain disorder [ICD-11: 8E43] |
| Q8NER1 | TRPV1_HUMAN | Knee osteoarthritis [ICD-11: FA01] |
| Q8NER1 | TRPV1_HUMAN | Lower limb mononeuropathy [ICD-11: 8C11] |
| Q8NER1 | TRPV1_HUMAN | Pain [ICD-11: MG30-MG3Z] |
| Q8NER1 | TRPV1_HUMAN | Atopic eczema [ICD-11: EA80] |
| Q8NER1 | TRPV1_HUMAN | Chronic pain [ICD-11: MG30] |
| Q8NER1 | TRPV1_HUMAN | Functional bladder disorder [ICD-11: GC50] |
| Q8NER1 | TRPV1_HUMAN | Migraine [ICD-11: 8A80] |
| Q8NER1 | TRPV1_HUMAN | Osteoarthritis [ICD-11: FA00-FA05] |
| Q8NER1 | TRPV1_HUMAN | Rheumatoid arthritis [ICD-11: FA20] |
| Q8NER1 | TRPV1_HUMAN | Asthma [ICD-11: CA23] |
| Q8NER1 | TRPV1_HUMAN | Acute/chronic pain [ICD-11: MG30-MG31] |
| Q8NER1 | TRPV1_HUMAN | Esophagus sensitivity [ICD-11: DA2Y-DA2Z] |
| Q8NER1 | TRPV1_HUMAN | Gastro-oesophageal reflux disease [ICD-11: DA22] |
| Q8NER1 | TRPV1_HUMAN | Neuropathy [ICD-11: 8C0Z] |
| Q8NER1 | TRPV1_HUMAN | Zoster [ICD-11: 1E91] |
| Q8NER1 | TRPV1_HUMAN | Cough [ICD-11: MD12] |
| Q7Z2W7 | TRPM8_HUMAN | Upper respiratory tract disorder [ICD-11: CA0Z] |
| Q7Z2W7 | TRPM8_HUMAN | Pain [ICD-11: MG30-MG3Z] |
| Q7Z2W7 | TRPM8_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| Q7Z2W7 | TRPM8_HUMAN | General pain disorder [ICD-11: 8E43] |