Basic Information

Terpenoid ID TKC118895
Cell line 0
Protein target 10
DiseaseNCIT 0
ORDO 0
ICD 34

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC118895 HT-29 HT 29; HT29 10300.0 nM IC50 C4349
TKC118895 LAMA-84 Lama-84; LAMA84; Lama84 5000.0 nM IC50 C3174 Orphanet_521
TKC118895 A549 17900.0 nM IC50 C3512
TKC118895 PC-3 PC3; PC.3 17400.0 nM IC50 C4863
TKC118895 HepG2 10900.0 nM IC50 C3728 Orphanet_449
TKC118895 MCF7 13600.0 nM IC50 C4194
TKC118895 BJ 18400.0 nM IC50
TKC118895 SH-SY5Y SH-Sy5y; SHSY5Y; SHSY-5Y; SK-SH-SY5Y; SY5Y; SH-SY5Y Parental 17200.0 nM IC50 C3270 Orphanet_635

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC118895 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 18356 nM Potency
TKC118895 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 94 % Inhibition
TKC118895 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 90 % Inhibition
TKC118895 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 14 nM Potency
TKC118895 Q9UBT6 DNA polymerase kappa POLK 35481 nM Potency
TKC118895 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 89125 nM Potency
TKC118895 O00255 Menin MEN1 3162 nM Potency
TKC118895 Q92830 Histone acetyltransferase KAT2A KAT2A 31623 nM Potency
TKC118895 P02545 Prelamin-A/C LMNA 12589 nM Potency
TKC118895 O75604 Ubiquitin carboxyl-terminal hydrolase 2 USP2 3162 nM Potency
TKC118895 P04637 Cellular tumor antigen p53 TP53 31623 nM Potency
TKC118895 Q9UHC9 NPC1-like intracellular cholesterol transporter 1 NPC1L1 1700 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75604 UBP2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P04637 P53_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04637 P53_HUMAN Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
P04637 P53_HUMAN Metastatic liver/bile duct neoplasm [ICD-11: 2D80]
P04637 P53_HUMAN Transplant rejection [ICD-11: NE84]
P04637 P53_HUMAN Ovarian dysfunction [ICD-11: 5A80]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Bladder cancer [ICD-11: 2C94]
P04637 P53_HUMAN Brain cancer [ICD-11: 2A00]
P04637 P53_HUMAN Colorectal cancer [ICD-11: 2B91]
P04637 P53_HUMAN Esophageal cancer [ICD-11: 2B70]
P04637 P53_HUMAN Head and neck cancer [ICD-11: 2D42]
P04637 P53_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P04637 P53_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P04637 P53_HUMAN Ovarian cancer [ICD-11: 2C73]
P04637 P53_HUMAN Pancreatic cancer [ICD-11: 2C10]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Stomach cancer [ICD-11: 2B72]
P04637 P53_HUMAN Cervical cancer [ICD-11: 2C77]
P04637 P53_HUMAN Endometrial cancer [ICD-11: 2C76]
P04637 P53_HUMAN Fallopian tube cancer [ICD-11: 2C74]
P04637 P53_HUMAN Liposarcoma [ICD-11: 2B59]
P04637 P53_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P04637 P53_HUMAN Peritoneal cancer [ICD-11: 2C51]
P04637 P53_HUMAN Toxicity [ICD-11: N.A.]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Kidney failure [ICD-11: GB60-GB6Z]
P04637 P53_HUMAN Hearing disorder [ICD-11: AB50-AB57]
Q9UHC9 NPCL1_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]