Basic Information

Terpenoid ID TKC112754
Chirality TKC206757
Cell line 0
Protein target 21
DiseaseNCIT 0
ORDO 0
ICD 43

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC112754 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 100000.0 nM GI50 C105555
TKC112754 J774.A1 J-774A.1; J774.A1; J774 A1; J774A.1; J 774A.1; J774 A.1 141.0 nM IC50 C134780
TKC112754 MCF7 20000.0 nM IC50 C4194
TKC112754 SN12C SN-12C 100000.0 nM GI50 C9385 Orphanet_217071
TKC112754 MDA-N MDAN 100000.0 nM GI50 C3802
TKC112754 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 100000.0 nM GI50 C3512
TKC112754 ACHN 100000.0 nM GI50 C6975 Orphanet_319298
TKC112754 UO-31 UO.31; UO31; U031 100000.0 nM GI50 C9385 Orphanet_217071
TKC112754 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 100000.0 nM GI50 C4863
TKC112754 SF-539 SF-539; SF-539 BT; SF.539; SF 539 100000.0 nM GI50 C3796 Orphanet_251576
TKC112754 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 100000.0 nM GI50 C3224
TKC112754 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 100000.0 nM GI50 C3510
TKC112754 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 100000.0 nM GI50 C105555
TKC112754 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 100000.0 nM GI50 C9142 Orphanet_99861
TKC112754 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 100000.0 nM GI50 C105555
TKC112754 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 100000.0 nM GI50 C60781 Orphanet_94
TKC112754 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 100000.0 nM GI50 C105555
TKC112754 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 100000.0 nM GI50 C105555
TKC112754 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 100000.0 nM GI50 C60781 Orphanet_94
TKC112754 TK-10 TK.10; TK 10; TK10 100000.0 nM GI50 C4033 Orphanet_319276
TKC112754 SR SR-786; SR786 100000.0 nM GI50 C37193 Orphanet_300895
TKC112754 SW-620 SW-620; SW 620; SW.620 100000.0 nM GI50 C4349
TKC112754 KM12 KM-12; KM.12 100000.0 nM GI50 C4910
TKC112754 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 100000.0 nM GI50 C3512
TKC112754 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 100000.0 nM GI50 C3802
TKC112754 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 100000.0 nM GI50 C3242 Orphanet_29073
TKC112754 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 100000.0 nM GI50 C3802
TKC112754 BT-549 BT 549; BT.549; BT549 100000.0 nM GI50 C4194
TKC112754 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 100000.0 nM GI50 C3224
TKC112754 A549 20000.0 nM IC50 C3512
TKC112754 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 100000.0 nM GI50 C3058 Orphanet_360
TKC112754 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 100000.0 nM GI50 C4349
TKC112754 HCT-15 HCT-15; HCT.15; HCT15 100000.0 nM GI50 C4349
TKC112754 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 100000.0 nM GI50 C4910
TKC112754 SF-268 SF-268; SF.268; SF 268 100000.0 nM GI50 C60781 Orphanet_94
TKC112754 EKVX 75162.0 nM GI50 C3512
TKC112754 PC-3 PC3; PC.3 100000.0 nM GI50 C4863
TKC112754 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 100000.0 nM GI50 C7978
TKC112754 T47D 2550.0 nM IC50 C4194
TKC112754 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 100000.0 nM GI50 C3224
TKC112754 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 100000.0 nM GI50 C3224
TKC112754 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 100000.0 nM GI50 C3802
TKC112754 SF-295 SF-295; SF.295; SF 295 100000.0 nM GI50 C3058 Orphanet_360
TKC112754 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 45604.0 nM GI50 C4194
TKC112754 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 100000.0 nM GI50 C3224
TKC112754 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 100000.0 nM GI50 C9385 Orphanet_217071
TKC112754 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 100000.0 nM GI50 C45662 Orphanet_50251
TKC112754 HT-29 HT 29; HT29 50000.0 nM IC50 C4349
TKC112754 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 100000.0 nM GI50 C3510
TKC112754 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 100000.0 nM GI50 C9385 Orphanet_217071
TKC112754 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 100000.0 nM GI50 C4349
TKC112754 Jurkat JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024 46500.0 nM IC50 C7953 Orphanet_99861

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC112754 P11473 Vitamin D3 receptor VDR 79433 nM Potency
TKC112754 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 9200 nM Potency
TKC112754 P08684 Cytochrome P450 3A4 CYP3A4 15849 nM Potency
TKC112754 P15207 Androgen receptor Ar 29512 nM IC50
TKC112754 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 794 nM Potency
TKC112754 P37840 Alpha-synuclein SNCA 2239 nM Potency
TKC112754 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 89125 nM Potency
TKC112754 Q13148 TAR DNA-binding protein 43 TARDBP 15849 nM Potency
TKC112754 P0DTD1 Replicase polyprotein 1ab rep 7 % Inhibition
TKC112754 P83916 Chromobox protein homolog 1 CBX1 100000 nM Potency
TKC112754 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 22 nM Potency
TKC112754 Q01453 Peripheral myelin protein 22 PMP22 95283 nM Potency
TKC112754 O00255 Menin MEN1 39811 nM Potency
TKC112754 P02545 Prelamin-A/C LMNA 35481 nM Potency
TKC112754 Q194T2 Non-structural protein 1 NS1 14125 nM Potency
TKC112754 P22310 UDP-glucuronosyltransferase 1A4 UGT1A4 34 pm/min/mg Activity
TKC112754 P54855 UDP-glucuronosyltransferase 2B15 UGT2B15 0 pm/min/mg Activity
TKC112754 P25094 Peripheral myelin protein 22 Pmp22 40533 nM Potency
TKC112754 O35627 Nuclear receptor subfamily 1 group I member 3 Nr1i3 71 % Remaining activity
TKC112754 P04278 Sex hormone-binding globulin SHBG 14 nM Kd
TKC112754 P08185 Corticosteroid-binding globulin SERPINA6 10000 nM Ki
TKC112754 P56937 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 HSD17B7 6 % Inhibition
TKC112754 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 3330 nM EC50
TKC112754 P11413 Glucose-6-phosphate 1-dehydrogenase G6PD 6200 nM Ki
TKC112754 P11413 Glucose-6-phosphate 1-dehydrogenase G6PD 24900 nM IC50
TKC112754 O75795 UDP-glucuronosyltransferase 2B17 UGT2B17 0 pm/min/mg Activity
TKC112754 Q9GRG7 Glucose-6-phosphate 1-dehydrogenase g6pd 1100 nM Ki
TKC112754 Q9UHC9 NPC1-like intracellular cholesterol transporter 1 NPC1L1 >10000 nM EC50
TKC112754 Q9Y6A2 Cholesterol 24-hydroxylase CYP46A1 56 % Activity
TKC112754 P05804 Beta-glucuronidase uidA 77900 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P37840 SYUA_HUMAN Parkinsonism [ICD-11: 8A00]
P37840 SYUA_HUMAN Alzheimer disease [ICD-11: 8A20]
P37840 SYUA_HUMAN Autonomic nervous system disorder [ICD-11: 8D87]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08185 CBG_HUMAN Asthma [ICD-11: CA23]
P08185 CBG_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P08185 CBG_HUMAN Respiratory system disease [ICD-11: CB40-CB7Z]
P08185 CBG_HUMAN Retinopathy [ICD-11: 9B71]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P11413 G6PD_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P11413 G6PD_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P11413 G6PD_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P11413 G6PD_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P11413 G6PD_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P11413 G6PD_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q9UHC9 NPCL1_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q9Y6A2 CP46A_HUMAN Acidosis [ICD-11: 5C73]
Q9Y6A2 CP46A_HUMAN Epilepsy/seizure [ICD-11: 8A61-8A6Z]
Q9Y6A2 CP46A_HUMAN Epileptic encephalopathy [ICD-11: 8A62]
Q9Y6A2 CP46A_HUMAN Phakomatoses/hamartoneoplastic syndrome [ICD-11: LD2D]
Q9Y6A2 CP46A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P05804 BGLR_ECOLI Therapeutic intestinal toxicity [ICD-11: DA94]