Basic Information

Terpenoid ID TKC012269
Cell line 0
Protein target 6
DiseaseNCIT 0
ORDO 0
ICD 6

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC012269 A549 18323.0 nM GI50 C3512
TKC012269 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 1807.0 nM GI50 C4910
TKC012269 MIA PaCa-2 MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2; MiaPaCa 22500.0 nM IC50 C9120
TKC012269 SN12C SN-12C 5559.0 nM GI50 C9385 Orphanet_217071
TKC012269 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 13740.0 nM GI50 C3512
TKC012269 UO-31 UO.31; UO31; U031 6637.0 nM GI50 C9385 Orphanet_217071
TKC012269 ACHN 5821.0 nM GI50 C6975 Orphanet_319298
TKC012269 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 2366.0 nM GI50 C9154 Orphanet_519
TKC012269 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 4178.0 nM GI50 C2926
TKC012269 SF-539 SF-539; SF-539 BT; SF.539; SF 539 5333.0 nM GI50 C3796 Orphanet_251576
TKC012269 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 12331.0 nM GI50 C3510
TKC012269 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 4742.0 nM GI50 C3224
TKC012269 A498 A498 17418.0 nM GI50 C9385 Orphanet_217071
TKC012269 K562 K562; K.562; K 562; KO; GM05372; GM05372E 2673.0 nM GI50 C9110 Orphanet_521
TKC012269 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 2582.0 nM GI50 C105555
TKC012269 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 2193.0 nM GI50 C9142 Orphanet_99861
TKC012269 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 19634.0 nM GI50 C3512
TKC012269 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 14158.0 nM GI50 C60781 Orphanet_94
TKC012269 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 19364.0 nM GI50 C105555
TKC012269 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 4285.0 nM GI50 C105555
TKC012269 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 17179.0 nM GI50 C60781 Orphanet_94
TKC012269 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 4335.0 nM GI50 C4917 Orphanet_70573
TKC012269 SR SR-786; SR786 2360.0 nM GI50 C37193 Orphanet_300895
TKC012269 SW-620 SW-620; SW 620; SW.620 3148.0 nM GI50 C4349
TKC012269 M19-MEL M-19; M19 2564.0 nM GI50 C3802
TKC012269 TK-10 TK.10; TK 10; TK10 3141.0 nM GI50 C4033 Orphanet_319276
TKC012269 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 1786.0 nM GI50 C3512
TKC012269 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 5458.0 nM GI50 C3802
TKC012269 XF498 XF-498; XF498 15346.0 nM GI50 C3058 Orphanet_360
TKC012269 KM12 KM-12; KM.12 16144.0 nM GI50 C4910
TKC012269 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 15453.0 nM GI50 C2923
TKC012269 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 2123.0 nM GI50 C3242 Orphanet_29073
TKC012269 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 1774.0 nM GI50 C105555
TKC012269 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 12162.0 nM GI50 C3802
TKC012269 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 16982.0 nM GI50 C3224
TKC012269 KM-20L2 KM-20L2; KM 20L2; KM 2012 20277.0 nM GI50 C4349
TKC012269 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 18408.0 nM GI50 C4349
TKC012269 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 15346.0 nM GI50 C3058 Orphanet_360
TKC012269 HCT-15 HCT-15; HCT.15; HCT15 1991.0 nM GI50 C4349
TKC012269 SF-268 SF-268; SF.268; SF 268 6902.0 nM GI50 C60781 Orphanet_94
TKC012269 EKVX 14454.0 nM GI50 C3512
TKC012269 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 1862.0 nM GI50 C2926
TKC012269 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 5781.0 nM GI50 C4917 Orphanet_70573
TKC012269 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 18072.0 nM GI50 C7978
TKC012269 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 17338.0 nM GI50 C4450
TKC012269 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 5662.0 nM GI50 C3224
TKC012269 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 2466.0 nM GI50 C3224
TKC012269 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 5929.0 nM GI50 C7979 Orphanet_454723
TKC012269 SF-295 SF-295; SF.295; SF 295 17179.0 nM GI50 C3058 Orphanet_360
TKC012269 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 15885.0 nM GI50 C9385 Orphanet_217071
TKC012269 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 3076.0 nM GI50 C3224
TKC012269 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 5649.0 nM GI50 C9385 Orphanet_217071
TKC012269 SNB-78 SNB78; Surgical Neurology Branch-78 3855.0 nM GI50 C3058 Orphanet_360
TKC012269 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 1175.0 nM GI50 C7953 Orphanet_99861
TKC012269 DLD-1 DLD 1; DLD1; CoCL3 2153.0 nM GI50 C4349
TKC012269 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 20464.0 nM GI50 C45662 Orphanet_50251
TKC012269 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 5623.0 nM GI50 C3510
TKC012269 HT-29 HT 29; HT29 20137.0 nM GI50 C4349
TKC012269 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 4188.0 nM GI50 C4349
TKC012269 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 1849.0 nM GI50 C9385 Orphanet_217071
TKC012269 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 2576.0 nM GI50 C4450
TKC012269 HepG2 7100.0 nM EC50 C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC012269 P06276 Cholinesterase BCHE 6 % Inhibition
TKC012269 P22303 Acetylcholinesterase ACHE >22 % Inhibition
TKC012269 P23141 Liver carboxylesterase 1 CES1 2530 nM Ki
TKC012269 Q72874 Protease pol 147600 nM IC50
TKC012269 P00784 Papain 88000 nM IC50
TKC012269 P0C6U8 Replicase polyprotein 1a 1a 21100 nM IC50
TKC012269 O00748 Cocaine esterase CES2 40 nM Ki
TKC012269 P10063 Gamma-aminobutyric acid receptor subunit alpha-2 GABRA2 300 nM IC50
TKC012269 P30304 M-phase inducer phosphatase 1 CDC25A >20 ug.mL-1 IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P06276 CHLE_HUMAN Pain [ICD-11: MG30-MG3Z]
P06276 CHLE_HUMAN Tonus and reflex abnormality [ICD-11: MB47]
P06276 CHLE_HUMAN Alzheimer disease [ICD-11: 8A20]
P06276 CHLE_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P06276 CHLE_HUMAN Eexposure to noxious substances harmful effect [ICD-11: NE61]
P06276 CHLE_HUMAN Toxicity [ICD-11: N.A.]
P06276 CHLE_HUMAN Unspecific substance harmful effect [ICD-11: NE6Z]
P22303 ACES_HUMAN Alzheimer disease [ICD-11: 8A20]
P22303 ACES_HUMAN Glaucoma [ICD-11: 9C61]
P22303 ACES_HUMAN Myasthenia gravis [ICD-11: 8C6Y]
P22303 ACES_HUMAN Oesophageal/gastroduodenal disorder [ICD-11: DD90]
P22303 ACES_HUMAN Pediculosis [ICD-11: 1G00]
P22303 ACES_HUMAN Unspecific substance harmful effect [ICD-11: NE6Z]
P22303 ACES_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P22303 ACES_HUMAN Parasitic worm infestation [ICD-11: 1F90]
P22303 ACES_HUMAN Dementia [ICD-11: 6D80-6D8Z]
P22303 ACES_HUMAN Pain [ICD-11: MG30-MG3Z]
P22303 ACES_HUMAN Parkinsonism [ICD-11: 8A00]
P22303 ACES_HUMAN Substance abuse [ICD-11: 6C40]
P22303 ACES_HUMAN Lips/oral mucosa miscellaneous disorder [ICD-11: DA02]
P22303 ACES_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P22303 ACES_HUMAN Urinary system disease [ICD-11: GC2Z]
P22303 ACES_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P23141 EST1_HUMAN Peroxisomal disease [ICD-11: 5C57]
P23141 EST1_HUMAN Synthesis disorder [ICD-11: 5C52-5C59]
P23141 EST1_HUMAN Arterial occlusive disease [ICD-11: BD40]
P23141 EST1_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
P23141 EST1_HUMAN Mature B-cell lymphoma [ICD-11: 2A85]
P23141 EST1_HUMAN Chronic arterial occlusive disease [ICD-11: BD4Z]
P30304 MPIP1_HUMAN Asthma [ICD-11: CA23]
P30304 MPIP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]