Basic Information
| Terpenoid ID | TKC122884 |
|
| Cell line | 0 | |
| Protein target | 15 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 116 |
| Terpenoid ID | TKC122884 |
|
| Cell line | 0 | |
| Protein target | 15 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 116 |
| ID | Cell Line | Synonyms | Value | Unit | Type | NCIt | ORDO |
|---|
| ID | Uniport | Pref_name | Gene name | value | unit | type |
|---|---|---|---|---|---|---|
| TKC122884 | P11473 | Vitamin D3 receptor | VDR | 35481 | nM | Potency |
| TKC122884 | P10275 | Androgen receptor | AR | 39811 | nM | Potency |
| TKC122884 | P15207 | Androgen receptor | Ar | >42658 | nM | IC50 |
| TKC122884 | Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | SLCO1B3 | 100 | % | Inhibition |
| TKC122884 | Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | SLCO1B1 | 96 | % | Inhibition |
| TKC122884 | O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | IDH1 | 96 | % | Activity |
| TKC122884 | Q16236 | Nuclear factor erythroid 2-related factor 2 | NFE2L2 | 54483 | nM | Potency |
| TKC122884 | Q9UBT6 | DNA polymerase kappa | POLK | 16834 | nM | Potency |
| TKC122884 | P08183 | ATP-dependent translocase ABCB1 | ABCB1 | 8200 | nM | IC50 |
| TKC122884 | P37840 | Alpha-synuclein | SNCA | 0 | a.u. | Activity |
| TKC122884 | P04150 | Glucocorticoid receptor | NR3C1 | 11220 | nM | Potency |
| TKC122884 | P0DTD1 | Replicase polyprotein 1ab | rep | 6 | % | Inhibition |
| TKC122884 | P02545 | Prelamin-A/C | LMNA | 6310 | nM | Potency |
| TKC122884 | Q03181 | Peroxisome proliferator-activated receptor delta | PPARD | 79433 | nM | Potency |
| TKC122884 | Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | <0 | RE | |
| TKC122884 | P06766 | DNA polymerase beta | Polb | >500000 | nM | IC50 |
| TKC122884 | P09884 | DNA polymerase alpha catalytic subunit | POLA1 | >500000 | nM | IC50 |
| TKC122884 | P51449 | Nuclear receptor ROR-gamma | RORC | 20 | nM | EC50 |
| TKC122884 | P11388 | DNA topoisomerase 2-alpha | TOP2A | >500000 | nM | IC50 |
| TKC122884 | Q9UNQ0 | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 | 0 | Activity | |
| TKC122884 | P35498 | Sodium channel protein type 1 subunit alpha | SCN1A | 3 | % | Inhibition |
| TKC122884 | P9WPL4 | Steroid C26-monooxygenase | cyp142 | 28 | /min | Kcat(app) |
| TKC122884 | P9WPL4 | Steroid C26-monooxygenase | cyp142 | 340 | nM | Kd |
| TKC122884 | P9WPL4 | Steroid C26-monooxygenase | cyp142 | 110 | nM | Kd |
| TKC122884 | Q16850 | Lanosterol 14-alpha demethylase | CYP51A1 | >200000 | nM | IC50 |
| TKC122884 | O00204 | Sulfotransferase 2B1 | SULT2B1 | 0 | Activity | |
| TKC122884 | Q9UHC9 | NPC1-like intracellular cholesterol transporter 1 | NPC1L1 | 0 | Activity | |
| TKC122884 | Q9Y6A2 | Cholesterol 24-hydroxylase | CYP46A1 | 670 | nM | Kd |
| TKC122884 | P00189 | Cholesterol side-chain cleavage enzyme, mitochondrial | CYP11A1 | 4500 | nM | Km |
| TKC122884 | Q05320 | Envelope glycoprotein | GP | 0 | Inhibition | |
| TKC122884 | Q969R2 | Oxysterol-binding protein 2 | OSBP2 | 68 | nM | Kd |
| Uniport ID | Uniport Name | ICD-11 | Disease |
|---|---|---|---|
| P10275 | ANDR_HUMAN | ICD-11: ED80 | vulgaris |
| P10275 | ANDR_HUMAN | ICD-11: 2A60 | leukaemia |
| P10275 | ANDR_HUMAN | ICD-11: DB94 | disease |
| P10275 | ANDR_HUMAN | ICD-11: 2C60-2C6Y | cancer |
| P10275 | ANDR_HUMAN | ICD-11: BA00-BE2Z | disease |
| P10275 | ANDR_HUMAN | ICD-11: CA22 | disease |
| P10275 | ANDR_HUMAN | ICD-11: GA34 | pain |
| P10275 | ANDR_HUMAN | ICD-11: 5C72 | Hypo-osmolality/hyponatraemia |
| P10275 | ANDR_HUMAN | ICD-11: FB83 | disorder |
| P10275 | ANDR_HUMAN | ICD-11: 2C60-2C6Z | tumour |
| P10275 | ANDR_HUMAN | ICD-11: 5A60-5A61 | disorder |
| P10275 | ANDR_HUMAN | ICD-11: 2C82 | cancer |
| P10275 | ANDR_HUMAN | ICD-11: 5A81 | dysfunction |
| P10275 | ANDR_HUMAN | ICD-11: GA90 | hyperplasia |
| P10275 | ANDR_HUMAN | ICD-11: ED70 | Alopecia |
| P10275 | ANDR_HUMAN | ICD-11: GB61 | disease |
| P10275 | ANDR_HUMAN | ICD-11: DB61-GB90 | Thrombosis |
| P10275 | ANDR_HUMAN | ICD-11: QA21 | management |
| P10275 | ANDR_HUMAN | ICD-11: BD10-BD1Z | failure |
| P10275 | ANDR_HUMAN | ICD-11: FB32-FB3Z | disorder |
| P10275 | ANDR_HUMAN | ICD-11: 8C70 | dystrophy |
| P10275 | ANDR_HUMAN | ICD-11: CA25 | fibrosis |
| P10275 | ANDR_HUMAN | ICD-11: MG30-MG3Z | Pain |
| P10275 | ANDR_HUMAN | ICD-11: MG20 | Cachexia |
| P10275 | ANDR_HUMAN | ICD-11: 6B60 | disorder |
| P10275 | ANDR_HUMAN | ICD-11: 2C94 | cancer |
| P10275 | ANDR_HUMAN | ICD-11: DA24 | Oesophagitis |
| P10275 | ANDR_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| P10275 | ANDR_HUMAN | ICD-11: GA90 | hyperplasia |
| P10275 | ANDR_HUMAN | ICD-11: 2C60-2C6Y | cancer |
| P10275 | ANDR_HUMAN | ICD-11: 2C82 | cancer |
| P10275 | ANDR_HUMAN | ICD-11: ED80 | vulgaris |
| P10275 | ANDR_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| O75874 | IDHC_HUMAN | ICD-11: 2A60 | leukaemia |
| O75874 | IDHC_HUMAN | ICD-11: 2C12 | cancer |
| O75874 | IDHC_HUMAN | ICD-11: 2B33 | neoplasm |
| O75874 | IDHC_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| O75874 | IDHC_HUMAN | ICD-11: 2A60 | leukaemia |
| O75874 | IDHC_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| Q16236 | NF2L2_HUMAN | ICD-11: 8A03 | disorder |
| Q16236 | NF2L2_HUMAN | ICD-11: 2C60-2C6Y | cancer |
| Q16236 | NF2L2_HUMAN | ICD-11: 9C61 | Glaucoma |
| Q16236 | NF2L2_HUMAN | ICD-11: 2C25 | cancer |
| Q16236 | NF2L2_HUMAN | ICD-11: 9B75 | degeneration |
| Q16236 | NF2L2_HUMAN | ICD-11: 2C30 | Melanoma |
| Q16236 | NF2L2_HUMAN | ICD-11: 6E20-6E8Z | disorder |
| Q16236 | NF2L2_HUMAN | ICD-11: BB01 | hypertension |
| Q16236 | NF2L2_HUMAN | ICD-11: 8B01 | haemorrhage |
| Q16236 | NF2L2_HUMAN | ICD-11: MF8Y | sympton |
| Q16236 | NF2L2_HUMAN | ICD-11: DB92 | disease |
| Q16236 | NF2L2_HUMAN | ICD-11: 5C5A | deficiency |
| Q16236 | NF2L2_HUMAN | ICD-11: 8B60 | disease |
| Q16236 | NF2L2_HUMAN | ICD-11: 8A40 | sclerosis |
| P08183 | MDR1_HUMAN | ICD-11: 2C25 | cancer |
| P08183 | MDR1_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| P08183 | MDR1_HUMAN | ICD-11: 1A00-1C4Z | infection |
| P08183 | MDR1_HUMAN | ICD-11: 2A60 | leukaemia |
| P08183 | MDR1_HUMAN | ICD-11: 2D11 | cancer |
| P08183 | MDR1_HUMAN | ICD-11: 2C73 | cancer |
| P37840 | SYUA_HUMAN | ICD-11: 8A00 | Parkinsonism |
| P37840 | SYUA_HUMAN | ICD-11: 8A20 | disease |
| P37840 | SYUA_HUMAN | ICD-11: 8D87 | disorder |
| P04150 | GCR_HUMAN | ICD-11: 5A2Y | complication |
| P04150 | GCR_HUMAN | ICD-11: DD72 | colitis |
| P04150 | GCR_HUMAN | ICD-11: 8A40 | sclerosis |
| P04150 | GCR_HUMAN | ICD-11: 8C70 | dystrophy |
| P04150 | GCR_HUMAN | ICD-11: 2C82 | cancer |
| P04150 | GCR_HUMAN | ICD-11: FA20 | arthritis |
| P04150 | GCR_HUMAN | ICD-11: 5A11 | mellitus |
| P04150 | GCR_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| P04150 | GCR_HUMAN | ICD-11: 4A01 | immunodeficiency |
| P04150 | GCR_HUMAN | ICD-11: 5A71 | disorder |
| P04150 | GCR_HUMAN | ICD-11: 4A80-4A8Z | disorder |
| P04150 | GCR_HUMAN | ICD-11: CA23 | Asthma |
| P04150 | GCR_HUMAN | ICD-11: EA80 | eczema |
| P04150 | GCR_HUMAN | ICD-11: CA22 | disease |
| P04150 | GCR_HUMAN | ICD-11: 5A70 | syndrome |
| P04150 | GCR_HUMAN | ICD-11: EA80-EA89 | Eczema |
| P04150 | GCR_HUMAN | ICD-11: 8A40 | sclerosis |
| P04150 | GCR_HUMAN | ICD-11: 8C70 | dystrophy |
| P04150 | GCR_HUMAN | ICD-11: DA24 | Oesophagitis |
| P04150 | GCR_HUMAN | ICD-11: 1A00-CA43 | inflammation |
| P04150 | GCR_HUMAN | ICD-11: FA20 | arthritis |
| P04150 | GCR_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| P04150 | GCR_HUMAN | ICD-11: ND51 | injury |
| P04150 | GCR_HUMAN | ICD-11: CA08 | rhinitis |
| P04150 | GCR_HUMAN | ICD-11: 1F00 | infection |
| P04150 | GCR_HUMAN | ICD-11: AA00-AA13 | externa |
| P04150 | GCR_HUMAN | ICD-11: 6C40 | abuse |
| P04150 | GCR_HUMAN | ICD-11: 2C60-2C6Y | cancer |
| P04150 | GCR_HUMAN | ICD-11: 6A70-6A7Z | Depression |
| P04150 | GCR_HUMAN | ICD-11: 6A60-6E23 | disorder |
| P04150 | GCR_HUMAN | ICD-11: 5A11 | mellitus |
| P04150 | GCR_HUMAN | ICD-11: 5B55-5B5F | deficiency |
| P04150 | GCR_HUMAN | ICD-11: 9B71 | Retinopathy |
| P04150 | GCR_HUMAN | ICD-11: 6B00-6B0Z | disorder |
| Q03181 | PPARD_HUMAN | ICD-11: DB92 | disease |
| Q03181 | PPARD_HUMAN | ICD-11: 5A11 | mellitus |
| Q03181 | PPARD_HUMAN | ICD-11: DB96 | disease |
| Q03181 | PPARD_HUMAN | ICD-11: 5C80 | Hyper-lipoproteinaemia |
| Q03181 | PPARD_HUMAN | ICD-11: 5B80-5B81 | Obesity |
| Q03181 | PPARD_HUMAN | ICD-11: 8A20 | disease |
| Q03181 | PPARD_HUMAN | ICD-11: 5C80-5C81 | Dyslipidemia |
| Q03181 | PPARD_HUMAN | ICD-11: 5C50-5D2Z | disorder |
| Q03181 | PPARD_HUMAN | ICD-11: 5A10 | mellitus |
| Q03181 | PPARD_HUMAN | ICD-11: 8A04-8D87 | disease |
| Q13133 | NR1H3_HUMAN | ICD-11: 6A70-6A7Z | Depression |
| P09884 | DPOLA_HUMAN | ICD-11: 1A24-1D9Z | infection |
| P51449 | RORG_HUMAN | ICD-11: 4A40-4A45 | disease |
| P51449 | RORG_HUMAN | ICD-11: 2C25 | cancer |
| P51449 | RORG_HUMAN | ICD-11: EA90 | Psoriasis |
| P51449 | RORG_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| P51449 | RORG_HUMAN | ICD-11: DD70 | disease |
| P51449 | RORG_HUMAN | ICD-11: 8A40 | sclerosis |
| P51449 | RORG_HUMAN | ICD-11: BD40 | disease |
| P51449 | RORG_HUMAN | ICD-11: 2C12 | cancer |
| P51449 | RORG_HUMAN | ICD-11: FA20 | arthritis |
| P11388 | TOP2A_HUMAN | ICD-11: 2B57 | sarcoma |
| P11388 | TOP2A_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| P11388 | TOP2A_HUMAN | ICD-11: 2A60 | leukaemia |
| P11388 | TOP2A_HUMAN | ICD-11: 2A90 | lymphoma |
| Q9UNQ0 | ABCG2_HUMAN | ICD-11: DD91 | syndrome |
| Q9UNQ0 | ABCG2_HUMAN | ICD-11: FA20 | arthritis |
| Q16850 | CP51A_HUMAN | ICD-11: 1D01 | meningitis |
| Q16850 | CP51A_HUMAN | ICD-11: EE12 | infection |
| Q16850 | CP51A_HUMAN | ICD-11: 1F6A | Onchocerciasis |
| Q9UHC9 | NPCL1_HUMAN | ICD-11: 5C80 | Hyper-lipoproteinaemia |
| Q9Y6A2 | CP46A_HUMAN | ICD-11: 5C73 | Acidosis |
| Q9Y6A2 | CP46A_HUMAN | ICD-11: 8A61-8A6Z | Epilepsy/seizure |
| Q9Y6A2 | CP46A_HUMAN | ICD-11: 8A62 | encephalopathy |
| Q9Y6A2 | CP46A_HUMAN | ICD-11: LD2D | syndrome |
| Q9Y6A2 | CP46A_HUMAN | ICD-11: 2A00-2F9Z | tumour/cancer |
| Q05320 | VGP_EBOZM | ICD-11: 1D60 | disease |