Basic Information

Terpenoid ID TKC152742
Chirality TKC057392
Cell line 0
Protein target 4
DiseaseNCIT 0
ORDO 0
ICD 15

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC152742 H9 HT clone H9; HT(H9); H 9; H-9 23000.0 nM EC50 C3366 Orphanet_3162
TKC152742 J774 J-774 67100.0 nM IC50 C134780
TKC152742 Raji RAJI; P1-Raji; GM04671 80.0 % Activity C27694 Orphanet_543
TKC152742 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 30940.0 nM IC50 C9154 Orphanet_519
TKC152742 MCF7 43880.0 nM IC50 C4194
TKC152742 DLD-1 DLD 1; DLD1; CoCL3 6600.0 nM IC50 C4349
TKC152742 A549 3800.0 nM IC50 C3512
TKC152742 B16 B-16; B16 melanoma; B16 subline B78; B78 27400.0 nM IC50 C21790
TKC152742 WI-38 VA13 WI 38 VA13 subline 2RA; WI 38 VA-13 subline 2RA; WI 38VA13 subline 2RA; WI-38 VA13 sub 2 RA; WI38-VA13 subline 2RA; WI38 VA13/2RA; WI38VA13/2RA; VA13 2RA; WI-38 VA13; WI 38 VA 13; WI38-VA13; WI38/VA13; WI38VA13; VA-13; VA13; AG07217; AG7217 20300.0 nM IC50
TKC152742 A2780 A-2780; 2780; A2780S; A2780par 6100.0 nM IC50 C7979 Orphanet_454723
TKC152742 ADR5000 cell line CCRF ADR5000; CCRF-ADR5000; CEM/ADR5000; CEM/ADR 5000; CEM-ADR5000; CEM ADR5000; ADR5000 56500.0 nM IC50 C7953 Orphanet_99861
TKC152742 SN12C SN-12C 24831.0 nM GI50 C9385 Orphanet_217071
TKC152742 MDA-N MDAN 44978.0 nM GI50 C3802
TKC152742 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 94842.0 nM GI50 C3512
TKC152742 ACHN 11143.0 nM GI50 C6975 Orphanet_319298
TKC152742 UO-31 UO.31; UO31; U031 11092.0 nM GI50 C9385 Orphanet_217071
TKC152742 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 16711.0 nM GI50 C2926
TKC152742 SF-539 SF-539; SF-539 BT; SF.539; SF 539 11749.0 nM GI50 C3796 Orphanet_251576
TKC152742 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 136700.0 nM IC50 C4863
TKC152742 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 52481.0 nM GI50 C3224
TKC152742 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 19679.0 nM GI50 C3510
TKC152742 A498 A498 21528.0 nM GI50 C9385 Orphanet_217071
TKC152742 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 10000.0 nM IC50 C105555
TKC152742 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 16672.0 nM GI50 C3512
TKC152742 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 32359.0 nM GI50 C9142 Orphanet_99861
TKC152742 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 30409.0 nM GI50 C105555
TKC152742 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 11803.0 nM GI50 C60781 Orphanet_94
TKC152742 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 12531.0 nM GI50 C105555
TKC152742 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 55719.0 nM GI50 C105555
TKC152742 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 96190.0 nM IC50 C5214
TKC152742 TK-10 TK.10; TK 10; TK10 17100.0 nM GI50 C4033 Orphanet_319276
TKC152742 SR SR-786; SR786 42954.0 nM GI50 C37193 Orphanet_300895
TKC152742 SW-620 SW-620; SW 620; SW.620 20137.0 nM GI50 C4349
TKC152742 KM12 KM-12; KM.12 9705.0 nM GI50 C4910
TKC152742 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 20370.0 nM GI50 C3512
TKC152742 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 51051.0 nM GI50 C3802
TKC152742 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 3581.0 nM GI50 C2923
TKC152742 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 14622.0 nM GI50 C3802
TKC152742 BT-549 BT 549; BT.549; BT549 17579.0 nM GI50 C4194
TKC152742 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 12735.0 nM GI50 C3058 Orphanet_360
TKC152742 HCT-15 HCT-15; HCT.15; HCT15 42560.0 nM GI50 C4349
TKC152742 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 30832.0 nM GI50 C4910
TKC152742 SF-268 SF-268; SF.268; SF 268 25119.0 nM GI50 C60781 Orphanet_94
TKC152742 EKVX 25586.0 nM GI50 C3512
TKC152742 T47D 20720.0 nM IC50 C4194
TKC152742 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 7.0 ug.mL-1 GI50 C4450
TKC152742 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 15346.0 nM GI50 C3224
TKC152742 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 10000.0 nM IC50 C3802
TKC152742 SF-295 SF-295; SF.295; SF 295 14028.0 nM GI50 C3058 Orphanet_360
TKC152742 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 34754.0 nM GI50 C7979 Orphanet_454723
TKC152742 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 23281.0 nM GI50 C3224
TKC152742 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 13614.0 nM GI50 C9385 Orphanet_217071
TKC152742 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 38994.0 nM GI50 C45662 Orphanet_50251
TKC152742 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 33113.0 nM GI50 C3510
TKC152742 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 10257.0 nM GI50 C9385 Orphanet_217071
TKC152742 MGC-803 MGC803; MGc80-3 30200.0 nM IC50 C5248
TKC152742 Bcap37 BCap-37; Bcap-37; BCaP 37; BCap 37; Bcap 37; BCAP37; Bcap37 25500.0 nM IC50 C27677
TKC152742 A-375 A 375; A375; A375-MEL; A375-mel; A375mel 28000.0 nM IC50 C3802
TKC152742 HepG2 10700.0 nM IC50 C3728 Orphanet_449
TKC152742 BXPC-3 BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3 9.0 ug.mL-1 GI50 C9120
TKC152742 PANC-1 Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P 8.0 uM PC50 C9120

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC152742 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 92 % Inhibition
TKC152742 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 106 % Inhibition
TKC152742 Q04206 Transcription factor p65 RELA 8800 nM IC50
TKC152742 Q04206 Transcription factor p65 RELA 8800 nM IC50
TKC152742 O42275 Acetylcholinesterase ache 7 % Inhibition
TKC152742 P0DTD1 Replicase polyprotein 1ab rep 10 % Inhibition
TKC152742 P35354 Prostaglandin G/H synthase 2 PTGS2 <30 % Inhibition
TKC152742 P81908 Cholinesterase BCHE 0 % Inhibition
TKC152742 Q9WKE8 Reverse transcriptase reverse transcriptase >200 ug.mL-1 IC50
TKC152742 P05771 Protein kinase C beta type PRKCB >150000 nM IC50
TKC152742 Q02156 Protein kinase C epsilon type PRKCE >150000 nM IC50
TKC152742 Q96RI1 Bile acid receptor NR1H4 0 nM EC50
TKC152742 P11388 DNA topoisomerase 2-alpha TOP2A 38600 nM IC50
TKC152742 P00690 Pancreatic alpha-amylase AMY2 >200000 nM IC50
TKC152742 P00489 Glycogen phosphorylase, muscle form PYGM 16982 nM IC50
TKC152742 P00489 Glycogen phosphorylase, muscle form PYGM 17000 nM IC50
TKC152742 P00489 Glycogen phosphorylase, muscle form PYGM 41500 nM IC50
TKC152742 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 >0 % Efficacy

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P35354 PGH2_HUMAN Alzheimer disease [ICD-11: 8A20]
P35354 PGH2_HUMAN Chronic pain [ICD-11: MG30]
P35354 PGH2_HUMAN Endometriosis [ICD-11: GA10]
P35354 PGH2_HUMAN Female pelvic pain [ICD-11: GA34]
P35354 PGH2_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
P35354 PGH2_HUMAN Indeterminate colitis [ICD-11: DD72]
P35354 PGH2_HUMAN Knee osteoarthritis [ICD-11: FA01]
P35354 PGH2_HUMAN Migraine [ICD-11: 8A80]
P35354 PGH2_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
P35354 PGH2_HUMAN Pain [ICD-11: MG30-MG3Z]
P35354 PGH2_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P35354 PGH2_HUMAN Tuberculosis [ICD-11: 1B10-1B12]
P35354 PGH2_HUMAN Shoulder lesion [ICD-11: FB53]
P35354 PGH2_HUMAN Soft tissue disorder [ICD-11: FB56]
P35354 PGH2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P35354 PGH2_HUMAN Asthma [ICD-11: CA23]
P35354 PGH2_HUMAN Gout [ICD-11: FA25]
P35354 PGH2_HUMAN General pain disorder [ICD-11: 8E43]
P35354 PGH2_HUMAN Lupus erythematosus [ICD-11: 4A40]
P35354 PGH2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P35354 PGH2_HUMAN Large intestine polyp [ICD-11: DB35]
P35354 PGH2_HUMAN Lung cancer [ICD-11: 2C25]
P35354 PGH2_HUMAN Pancreatic cancer [ICD-11: 2C10]
P35354 PGH2_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P35354 PGH2_HUMAN Colorectal cancer [ICD-11: 2B91]
P35354 PGH2_HUMAN Fever [ICD-11: MG26]
P35354 PGH2_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P05771 KPCB_HUMAN Brain cancer [ICD-11: 2A00]
P05771 KPCB_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P05771 KPCB_HUMAN Diffuse large B-cell lymphoma [ICD-11: 2A81]
P05771 KPCB_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P05771 KPCB_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P05771 KPCB_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P05771 KPCB_HUMAN Transplant rejection [ICD-11: NE84]
P05771 KPCB_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P05771 KPCB_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P05771 KPCB_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q02156 KPCE_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
Q02156 KPCE_HUMAN Liver vascular disorder [ICD-11: DB98]
Q02156 KPCE_HUMAN Malaria [ICD-11: 1F40-1F45]
Q02156 KPCE_HUMAN Alzheimer disease [ICD-11: 8A20]
Q02156 KPCE_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q02156 KPCE_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q96RI1 NR1H4_HUMAN Autoimmune liver disease [ICD-11: DB96]
Q96RI1 NR1H4_HUMAN Cholelithiasis [ICD-11: DC11]
Q96RI1 NR1H4_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
Q96RI1 NR1H4_HUMAN Osteoarthritis [ICD-11: FA00-FA05]
Q96RI1 NR1H4_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96RI1 NR1H4_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q96RI1 NR1H4_HUMAN Chronic kidney disease [ICD-11: GB61]
Q96RI1 NR1H4_HUMAN Skeletal anomaly [ICD-11: LD24]
Q96RI1 NR1H4_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q96RI1 NR1H4_HUMAN Hyper-lipoproteinaemia [ICD-11: 5C80]
Q96RI1 NR1H4_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P11388 TOP2A_HUMAN Kaposi sarcoma [ICD-11: 2B57]
P11388 TOP2A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11388 TOP2A_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11388 TOP2A_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]