Basic Information

Terpenoid ID TKC206777
Chirality TKC113125
Cell line 0
Protein target 34
DiseaseNCIT 0
ORDO 0
ICD 55

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC206777 HepG2 562.0 nM Potency C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206777 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 29093 nM Potency
TKC206777 P08684 Cytochrome P450 3A4 CYP3A4 15849 nM Potency
TKC206777 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 90 % Inhibition
TKC206777 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 42 % Inhibition
TKC206777 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 23109 nM Potency
TKC206777 Q99700 Ataxin-2 ATXN2 39811 nM Potency
TKC206777 Q9UNA4 DNA polymerase iota POLI 89125 nM Potency
TKC206777 O75496 Geminin GMNN 10000 nM Potency
TKC206777 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 3162 nM Potency
TKC206777 Q13148 TAR DNA-binding protein 43 TARDBP 11220 nM Potency
TKC206777 Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 37933 nM Potency
TKC206777 P05177 Cytochrome P450 1A2 CYP1A2 10000 nM AC50
TKC206777 P0DTD1 Replicase polyprotein 1ab rep 1 % Inhibition
TKC206777 P11712 Cytochrome P450 2C9 CYP2C9 1995 nM AC50
TKC206777 P21728 D(1A) dopamine receptor DRD1 23109 nM Potency
TKC206777 P33261 Cytochrome P450 2C19 CYP2C19 19953 nM Potency
TKC206777 P83916 Chromobox protein homolog 1 CBX1 79433 nM Potency
TKC206777 P00811 Beta-lactamase ampC 4467 nM Potency
TKC206777 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 22 nM Potency
TKC206777 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 16354 nM Potency
TKC206777 P54132 Bloom syndrome protein BLM 44668 nM Potency
TKC206777 Q01453 Peripheral myelin protein 22 PMP22 67456 nM Potency
TKC206777 Q6W5P4 Neuropeptide S receptor NPSR1 3162 nM Potency
TKC206777 O00255 Menin MEN1 7943 nM Potency
TKC206777 P49798 Regulator of G-protein signaling 4 RGS4 597 nM Potency
TKC206777 Q9Y253 DNA polymerase eta POLH 44668 nM Potency
TKC206777 Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F APOBEC3F 3162 nM Potency
TKC206777 P02545 Prelamin-A/C LMNA 12589 nM Potency
TKC206777 P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABRA1 22 nM IC50
TKC206777 P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABRA1 160 nM EC50
TKC206777 P10063 Gamma-aminobutyric acid receptor subunit alpha-2 GABRA2 105 nM POT
TKC206777 P08482 Muscarinic acetylcholine receptor M1 Chrm1 891 nM Potency
TKC206777 P40225 Thrombopoietin THPO 7943 nM Potency
TKC206777 P16662 UDP-glucuronosyltransferase 2B7 UGT2B7 5 total picomoles Activity
TKC206777 O15648 ATP-dependent 6-phosphofructokinase pfk 7569 nM Potency
TKC206777 O35627 Nuclear receptor subfamily 1 group I member 3 Nr1i3 19 % Remaining activity
TKC206777 O09028 Gamma-aminobutyric acid receptor subunit pi Gabrp 51 nM IC50
TKC206777 P11413 Glucose-6-phosphate 1-dehydrogenase G6PD 4300 nM IC50
TKC206777 P06133 UDP-glucuronosyltransferase 2B4 UGT2B4 5 total picomoles Activity
TKC206777 O75795 UDP-glucuronosyltransferase 2B17 UGT2B17 0 pm/min/mg Activity
TKC206777 P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABRB3 76 nM EC50
TKC206777 Q8BHJ7 Gamma-aminobutyric acid receptor subunit alpha-5 Gabra5 871 nM EC50
TKC206777 Q04828 Aldo-keto reductase family 1 member C1 AKR1C1 7 /uM Km

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
Q13526 PIN1_HUMAN Lung cancer [ICD-11: 2C25]
Q13526 PIN1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P11712 CP2C9_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P21728 DRD1_HUMAN Abortion [ICD-11: JA00]
P21728 DRD1_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P21728 DRD1_HUMAN Hypertension [ICD-11: BA00-BA04]
P21728 DRD1_HUMAN Parkinsonism [ICD-11: 8A00]
P21728 DRD1_HUMAN Cocaine use disorder [ICD-11: 6C45]
P21728 DRD1_HUMAN Schizophrenia [ICD-11: 6A20]
P21728 DRD1_HUMAN Tic disorder [ICD-11: 8A05]
P21728 DRD1_HUMAN Dementia [ICD-11: 6D80-6D8Z]
P21728 DRD1_HUMAN Psychotic disorder [ICD-11: 6A20-6A25]
P21728 DRD1_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P21728 DRD1_HUMAN Pain [ICD-11: MG30-MG3Z]
P21728 DRD1_HUMAN Glaucoma [ICD-11: 9C61]
P21728 DRD1_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
P21728 DRD1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P21728 DRD1_HUMAN Unspecific substance use disorder [ICD-11: 6C4Z]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P14867 GBRA1_HUMAN Acute respiratory distress syndrome [ICD-11: CB00]
P14867 GBRA1_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
P14867 GBRA1_HUMAN Chronic insomnia [ICD-11: 7A00]
P14867 GBRA1_HUMAN Chronic pain [ICD-11: MG30]
P14867 GBRA1_HUMAN Corneal disease [ICD-11: 9A76-9A78]
P14867 GBRA1_HUMAN Cystitis [ICD-11: GC00]
P14867 GBRA1_HUMAN Depression [ICD-11: 6A70-6A7Z]
P14867 GBRA1_HUMAN Epilepsy/seizure [ICD-11: 8A61-8A6Z]
P14867 GBRA1_HUMAN Headache [ICD-11: 8A80-8A84]
P14867 GBRA1_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
P14867 GBRA1_HUMAN Liver vascular disorder [ICD-11: DB98]
P14867 GBRA1_HUMAN Malaria [ICD-11: 1F40-1F45]
P14867 GBRA1_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
P14867 GBRA1_HUMAN Status epilepticus [ICD-11: 8A66]
P14867 GBRA1_HUMAN Tonus and reflex abnormality [ICD-11: MB47]
P14867 GBRA1_HUMAN Tremor-related disorder [ICD-11: 8A04]
P14867 GBRA1_HUMAN Indeterminate colitis [ICD-11: DD72]
P14867 GBRA1_HUMAN Female pelvic pain [ICD-11: GA34]
P14867 GBRA1_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P14867 GBRA1_HUMAN Acute respiratory distress syndrome [ICD-11: CB00]
P14867 GBRA1_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
P14867 GBRA1_HUMAN Chronic insomnia [ICD-11: 7A00]
P14867 GBRA1_HUMAN Chronic pain [ICD-11: MG30]
P14867 GBRA1_HUMAN Corneal disease [ICD-11: 9A76-9A78]
P14867 GBRA1_HUMAN Cystitis [ICD-11: GC00]
P14867 GBRA1_HUMAN Depression [ICD-11: 6A70-6A7Z]
P14867 GBRA1_HUMAN Epilepsy/seizure [ICD-11: 8A61-8A6Z]
P14867 GBRA1_HUMAN Headache [ICD-11: 8A80-8A84]
P14867 GBRA1_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
P14867 GBRA1_HUMAN Liver vascular disorder [ICD-11: DB98]
P14867 GBRA1_HUMAN Malaria [ICD-11: 1F40-1F45]
P14867 GBRA1_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
P14867 GBRA1_HUMAN Status epilepticus [ICD-11: 8A66]
P14867 GBRA1_HUMAN Tonus and reflex abnormality [ICD-11: MB47]
P14867 GBRA1_HUMAN Tremor-related disorder [ICD-11: 8A04]
P14867 GBRA1_HUMAN Indeterminate colitis [ICD-11: DD72]
P14867 GBRA1_HUMAN Female pelvic pain [ICD-11: GA34]
P14867 GBRA1_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P40225 TPO_HUMAN Ischaemic/haemorrhagic stroke [ICD-11: 8B20]
P40225 TPO_HUMAN Myocardial infarction [ICD-11: BA41-BA43]
P11413 G6PD_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P11413 G6PD_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P11413 G6PD_HUMAN Rheumatoid arthritis [ICD-11: FA20]