Basic Information

Terpenoid ID TKC206754
Chirality TKC112745
Cell line 0
Protein target 35
DiseaseNCIT 0
ORDO 0
ICD 43

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC206754 T47D 1230.0 nM IC50 C4194
TKC206754 Jurkat JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024 28800.0 nM IC50 C7953 Orphanet_99861
TKC206754 HepG2 25119.0 nM Potency C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206754 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 29093 nM Potency
TKC206754 P08684 Cytochrome P450 3A4 CYP3A4 15849 nM Potency
TKC206754 P15207 Androgen receptor Ar 40738 nM IC50
TKC206754 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 91 % Inhibition
TKC206754 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 55 % Inhibition
TKC206754 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 5174 nM Potency
TKC206754 P43220 Glucagon-like peptide 1 receptor GLP1R 11220 nM Potency
TKC206754 P84022 Mothers against decapentaplegic homolog 3 SMAD3 6310 nM Potency
TKC206754 P19838 Nuclear factor NF-kappa-B p105 subunit NFKB1 1585 nM Potency
TKC206754 Q9UNA4 DNA polymerase iota POLI 89125 nM Potency
TKC206754 O75496 Geminin GMNN 29093 nM Potency
TKC206754 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 100000 nM Potency
TKC206754 P37840 Alpha-synuclein SNCA 3981 nM Potency
TKC206754 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 35481 nM Potency
TKC206754 Q13148 TAR DNA-binding protein 43 TARDBP 39811 nM Potency
TKC206754 P0DTD1 Replicase polyprotein 1ab rep -8 % Inhibition
TKC206754 P10635 Cytochrome P450 2D6 CYP2D6 12589 nM AC50
TKC206754 P33261 Cytochrome P450 2C19 CYP2C19 2512 nM AC50
TKC206754 P83916 Chromobox protein homolog 1 CBX1 79433 nM Potency
TKC206754 P00811 Beta-lactamase ampC 5623 nM Potency
TKC206754 P63096 Guanine nucleotide-binding protein G GNAI1 8913 nM Potency
TKC206754 O00255 Menin MEN1 39811 nM Potency
TKC206754 Q92830 Histone acetyltransferase KAT2A KAT2A 39811 nM Potency
TKC206754 Q9F4F7 4'-phosphopantetheinyl transferase ffp ffp 39811 nM Potency
TKC206754 P02545 Prelamin-A/C LMNA 501 nM Potency
TKC206754 P16473 Thyrotropin receptor TSHR 15849 nM Potency
TKC206754 Q194T2 Non-structural protein 1 NS1 11220 nM Potency
TKC206754 P22309 UDP-glucuronosyltransferase 1A1 UGT1A1 0 pm/min/mg Activity
TKC206754 P22310 UDP-glucuronosyltransferase 1A4 UGT1A4 36 pm/min/mg Activity
TKC206754 O60656 UDP-glucuronosyltransferase 1A9 UGT1A9 0 pm/min/mg Activity
TKC206754 P19224 UDP-glucuronosyltransferase 1-6 UGT1A6 0 pm/min/mg Activity
TKC206754 P54855 UDP-glucuronosyltransferase 2B15 UGT2B15 0 pm/min/mg Activity
TKC206754 Q9HAW8 UDP-glucuronosyltransferase 1A10 UGT1A10 0 pm/min/mg Activity
TKC206754 Q9HAW9 UDP-glucuronosyltransferase 1A8 UGT1A8 0 pm/min/mg Activity
TKC206754 Q9HAW7 UDP-glucuronosyltransferase 1A7 UGT1A7 0 pm/min/mg Activity
TKC206754 P16662 UDP-glucuronosyltransferase 2B7 UGT2B7 2 total picomoles Activity
TKC206754 P80244 ATP-dependent Clp protease proteolytic subunit clpP 25119 nM Potency
TKC206754 O35627 Nuclear receptor subfamily 1 group I member 3 Nr1i3 54 % Remaining activity
TKC206754 P04278 Sex hormone-binding globulin SHBG 708 nM Kd
TKC206754 P08185 Corticosteroid-binding globulin SERPINA6 5888 nM Ki
TKC206754 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 10600 nM Ki
TKC206754 P56937 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 HSD17B7 8 % Inhibition
TKC206754 O09028 Gamma-aminobutyric acid receptor subunit pi Gabrp 4140 nM IC50
TKC206754 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 2620 nM EC50
TKC206754 P11413 Glucose-6-phosphate 1-dehydrogenase G6PD 3000 nM Ki
TKC206754 P11413 Glucose-6-phosphate 1-dehydrogenase G6PD >200000 nM IC50
TKC206754 C4YTQ8 ATP-dependent molecular chaperone HSP82 CAWG_05553 1477 nM EC50
TKC206754 P06133 UDP-glucuronosyltransferase 2B4 UGT2B4 0 pm/min/mg Activity
TKC206754 O75795 UDP-glucuronosyltransferase 2B17 UGT2B17 0 pm/min/mg Activity
TKC206754 P36537 UDP-glucuronosyltransferase 2B10 UGT2B10 0 pm/min/mg Activity
TKC206754 P37058 Testosterone 17-beta-dehydrogenase 3 HSD17B3 182 nM IC50
TKC206754 Q9GRG7 Glucose-6-phosphate 1-dehydrogenase g6pd 460 nM Ki
TKC206754 B9W6M3 Serine/threonine-protein phosphatase CNA1 >180000 nM EC50
TKC206754 O54939 Testosterone 17-beta-dehydrogenase 3 Hsd17b3 90 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
P19838 NFKB1_HUMAN Muscular dystrophy [ICD-11: 8C70]
P19838 NFKB1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P19838 NFKB1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P37840 SYUA_HUMAN Parkinsonism [ICD-11: 8A00]
P37840 SYUA_HUMAN Alzheimer disease [ICD-11: 8A20]
P37840 SYUA_HUMAN Autonomic nervous system disorder [ICD-11: 8D87]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
P10635 CP2D6_HUMAN Insomnia [ICD-11: 7A00-7A0Z]
P10635 CP2D6_HUMAN Malaria [ICD-11: 1F40-1F45]
P10635 CP2D6_HUMAN Migraine [ICD-11: 8A80]
P16473 TSHR_HUMAN Hypo-thyroidism [ICD-11: 5A00]
P16473 TSHR_HUMAN Thyroid cancer [ICD-11: 2D10]
P22309 UD11_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]
P08185 CBG_HUMAN Asthma [ICD-11: CA23]
P08185 CBG_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P08185 CBG_HUMAN Respiratory system disease [ICD-11: CB40-CB7Z]
P08185 CBG_HUMAN Retinopathy [ICD-11: 9B71]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P11413 G6PD_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P11413 G6PD_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P11413 G6PD_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P11413 G6PD_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P11413 G6PD_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P11413 G6PD_HUMAN Rheumatoid arthritis [ICD-11: FA20]