Basic Information

Terpenoid ID TKC197335
Chirality TKC197337
Cell line 0
Protein target 13
DiseaseNCIT 0
ORDO 0
ICD 17

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC197335 SF-295 SF-295; SF.295; SF 295 268.0 nM GI50 C3058 Orphanet_360
TKC197335 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 22.0 nM GI50 C7979 Orphanet_454723
TKC197335 BJ 434.0 nM EC50
TKC197335 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 10.0 nM GI50 C4194
TKC197335 MDA-N MDAN 10.0 nM GI50 C3802
TKC197335 SN12C SN-12C 18.0 nM GI50 C9385 Orphanet_217071
TKC197335 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 38.0 nM GI50 C3512
TKC197335 ACHN 2773.0 nM GI50 C6975 Orphanet_319298
TKC197335 UO-31 UO.31; UO31; U031 4508.0 nM GI50 C9385 Orphanet_217071
TKC197335 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 30.0 nM GI50 C4863
TKC197335 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 10.0 nM GI50 C9154 Orphanet_519
TKC197335 SF-539 SF-539; SF-539 BT; SF.539; SF 539 11.0 nM GI50 C3796 Orphanet_251576
TKC197335 A498 A498 213.0 nM GI50 C9385 Orphanet_217071
TKC197335 K562 K562; K.562; K 562; KO; GM05372; GM05372E 16.0 nM GI50 C9110 Orphanet_521
TKC197335 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 16.0 nM GI50 C105555
TKC197335 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 10.0 nM GI50 C9142 Orphanet_99861
TKC197335 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 89.0 nM GI50 C3512
TKC197335 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 20797.0 nM GI50 C105555
TKC197335 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 141.0 nM GI50 C60781 Orphanet_94
TKC197335 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 80.0 nM GI50 C105555
TKC197335 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 83.0 nM GI50 C105555
TKC197335 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 10.0 nM GI50 C4917 Orphanet_70573
TKC197335 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 41.0 nM GI50 C5214
TKC197335 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 185.0 nM GI50 C60781 Orphanet_94
TKC197335 SR SR-786; SR786 44.0 nM GI50 C37193 Orphanet_300895
TKC197335 TK-10 TK.10; TK 10; TK10 705.0 nM GI50 C4033 Orphanet_319276
TKC197335 M19-MEL M-19; M19 10.0 nM GI50 C3802
TKC197335 SW-620 SW-620; SW 620; SW.620 10.0 nM GI50 C4349
TKC197335 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 12.0 nM GI50 C3512
TKC197335 KM12 KM-12; KM.12 10.0 nM GI50 C4910
TKC197335 XF498 XF-498; XF498 39.0 nM GI50 C3058 Orphanet_360
TKC197335 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 36.0 nM GI50 C3802
TKC197335 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 59.0 nM GI50 C2923
TKC197335 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 10.0 nM GI50 C3242 Orphanet_29073
TKC197335 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 24717.0 nM GI50 C105555
TKC197335 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 30.0 nM GI50 C3802
TKC197335 BT-549 BT 549; BT.549; BT549 24.0 nM GI50 C4194
TKC197335 KM-20L2 KM-20L2; KM 20L2; KM 2012 13.0 nM GI50 C4349
TKC197335 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 10.0 nM GI50 C3224
TKC197335 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 21.0 nM GI50 C4349
TKC197335 A549 83.0 nM GI50 C3512
TKC197335 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 10.0 nM GI50 C3058 Orphanet_360
TKC197335 HCT-15 HCT-15; HCT.15; HCT15 3034.0 nM GI50 C4349
TKC197335 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 10.0 nM GI50 C4910
TKC197335 SF-268 SF-268; SF.268; SF 268 59.0 nM GI50 C60781 Orphanet_94
TKC197335 EKVX 4808.0 nM GI50 C3512
TKC197335 PC-3 PC3; PC.3 16.0 nM GI50 C4863
TKC197335 MCF7 10.0 nM GI50 C4194
TKC197335 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 26.0 nM GI50 C7978
TKC197335 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 10.0 nM GI50 C4917 Orphanet_70573
TKC197335 T47D 27.0 nM GI50 C4194
TKC197335 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 22.0 nM GI50 C4450
TKC197335 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 1820.0 nM GI50 C3224
TKC197335 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 10.0 nM GI50 C3224
TKC197335 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 10.0 nM GI50 C3802
TKC197335 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 63.0 nM GI50 C9385 Orphanet_217071
TKC197335 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 22.0 nM GI50 C3224
TKC197335 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 10.0 nM GI50 C7953 Orphanet_99861
TKC197335 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 17418.0 nM GI50 C45662 Orphanet_50251
TKC197335 HT-29 HT 29; HT29 10.0 nM GI50 C4349
TKC197335 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 748.0 nM GI50 C3510
TKC197335 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 222.0 nM GI50 C9385 Orphanet_217071
TKC197335 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 10.0 nM GI50 C4349
TKC197335 MCF7 12.0 nM IC50 C4194
TKC197335 SW480 SW-480; SW 480; SW480E 59.0 nM IC50 C4349
TKC197335 A549 11.0 nM IC50 C3512
TKC197335 HepG2 95.0 nM IC50 C3728 Orphanet_449
TKC197335 A2780 A-2780; 2780; A2780S; A2780par 30.0 nM IC50 C7979 Orphanet_454723

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC197335 P04062 Lysosomal acid glucosylceramidase GBA1 14125 nM Potency
TKC197335 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 46 nM Potency
TKC197335 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 206 nM Potency
TKC197335 P43220 Glucagon-like peptide 1 receptor GLP1R 316 nM Potency
TKC197335 P84022 Mothers against decapentaplegic homolog 3 SMAD3 15849 nM Potency
TKC197335 Q99700 Ataxin-2 ATXN2 1122 nM Potency
TKC197335 O75496 Geminin GMNN 8200 nM Potency
TKC197335 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 259 nM Potency
TKC197335 P02791 Ferritin light chain FTL 8913 nM Potency
TKC197335 Q92830 Histone acetyltransferase KAT2A KAT2A 794 nM Potency
TKC197335 P51450 Nuclear receptor ROR-gamma Rorc 10000 nM Potency
TKC197335 O15118 NPC intracellular cholesterol transporter 1 NPC1 251 nM Potency
TKC197335 P51151 Ras-related protein Rab-9A RAB9A 2239 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]