Basic Information

Terpenoid ID TKC147779
Chirality TKC048346
Cell line 0
Protein target 2
DiseaseNCIT 0
ORDO 0
ICD 20

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC147779 SK-N-SH SK N SH; SKN-SH; SK-NSH; SKNSH; NSH 228.0 % Activity C3270 Orphanet_635
TKC147779 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 95.0 % Activity C60781 Orphanet_94
TKC147779 C6 C-6; C 6; RGC-6; RGC6; RGc6 58.0 % Activity C64069

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC147779 P11387 DNA topoisomerase 1 TOP1 >250000 nM IC50
TKC147779 P11388 DNA topoisomerase 2-alpha TOP2A >250000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11387 TOP1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P11387 TOP1_HUMAN Colorectal cancer [ICD-11: 2B91]
P11387 TOP1_HUMAN Lung cancer [ICD-11: 2C25]
P11387 TOP1_HUMAN Ovarian cancer [ICD-11: 2C73]
P11387 TOP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11387 TOP1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P11387 TOP1_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P11387 TOP1_HUMAN Stomach cancer [ICD-11: 2B72]
P11387 TOP1_HUMAN Brain cancer [ICD-11: 2A00]
P11387 TOP1_HUMAN Esophageal cancer [ICD-11: 2B70]
P11387 TOP1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P11387 TOP1_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P11387 TOP1_HUMAN Gastrointestinal stromal tumour [ICD-11: 2B5B]
P11387 TOP1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P11387 TOP1_HUMAN Mature B-cell lymphoma [ICD-11: 2A85]
P11387 TOP1_HUMAN Bladder cancer [ICD-11: 2C94]
P11388 TOP2A_HUMAN Kaposi sarcoma [ICD-11: 2B57]
P11388 TOP2A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11388 TOP2A_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11388 TOP2A_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]