Basic Information

Terpenoid ID TKC048346
Chirality TKC147779
Cell line 0
Protein target 1
DiseaseNCIT 0
ORDO 0
ICD 0

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC048346 Hepatocyte 105000.0 nM IC50
TKC048346 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 77.0 % Activity C60781 Orphanet_94
TKC048346 C6 C-6; C 6; RGC-6; RGC6; RGc6 81.0 % Activity C64069

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC048346 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 SIRT1 8 % Activity
TKC048346 P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 17 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q96EB6 SIR1_HUMAN Colorectal cancer [ICD-11: 2B91]
Q96EB6 SIR1_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q96EB6 SIR1_HUMAN Systemic sclerosis [ICD-11: 4A42]
Q96EB6 SIR1_HUMAN Vasculitis [ICD-11: 4A44]
Q96EB6 SIR1_HUMAN Choreiform disorder [ICD-11: 8A01]
Q96EB6 SIR1_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
Q96EB6 SIR1_HUMAN Obesity [ICD-11: 5B80-5B81]
Q96EB6 SIR1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q96EB6 SIR1_HUMAN Colon cancer [ICD-11: 2B90]
Q96EB6 SIR1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
Q96EB6 SIR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]