Basic Information

Terpenoid ID TKC135961
Chirality TKC150907
Cell line 0
Protein target 7
DiseaseNCIT 0
ORDO 0
ICD 45

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC135961 NIH3T3 NIH/3T3; NIH-3T3; NIH3T3; 3T3; 3T3NIH; 3T3-Swiss; Swiss-3T3; Swiss/3T3; Swiss 3T3; Swiss3T3 84.0 ug.mL-1 GI50
TKC135961 HUVEC HUV-EC-C; HUVEC 60.0 % Activity
TKC135961 K562 K562; K.562; K 562; KO; GM05372; GM05372E 6370.0 nM GI50 C9110 Orphanet_521
TKC135961 Leukemia cells 14000.0 nM IC50

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC135961 P08684 Cytochrome P450 3A4 CYP3A4 39811 nM Potency
TKC135961 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 98 % Inhibition
TKC135961 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 83 % Inhibition
TKC135961 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 89125 nM Potency
TKC135961 P40763 Signal transducer and activator of transcription 3 STAT3 73000 nM IC50
TKC135961 P0DTD1 Replicase polyprotein 1ab rep 11 % Inhibition
TKC135961 P28482 Mitogen-activated protein kinase 1 MAPK1 5012 nM Potency
TKC135961 O00255 Menin MEN1 562 nM Potency
TKC135961 P16050 Polyunsaturated fatty acid lipoxygenase ALOX15 ALOX15 12589 nM Potency
TKC135961 P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 3100 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P40763 STAT3_HUMAN Psoriasis [ICD-11: EA90]
P40763 STAT3_HUMAN Brain cancer [ICD-11: 2A00]
P40763 STAT3_HUMAN Colorectal cancer [ICD-11: 2B91]
P40763 STAT3_HUMAN Liver cancer [ICD-11: 2C12]
P40763 STAT3_HUMAN Malignant digestive organ neoplasm [ICD-11: 2C11]
P40763 STAT3_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P40763 STAT3_HUMAN Pancreatic cancer [ICD-11: 2C10]
P40763 STAT3_HUMAN Respiratory infection [ICD-11: CA07-CA4Z]
P40763 STAT3_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P40763 STAT3_HUMAN Immune system disease [ICD-11: 4A01-4B41]
P40763 STAT3_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P40763 STAT3_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P40763 STAT3_HUMAN Multiple myeloma [ICD-11: 2A83]
P40763 STAT3_HUMAN Mycosis fungoides [ICD-11: 2B01]
P40763 STAT3_HUMAN Ulcerative colitis [ICD-11: DD71]
P40763 STAT3_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P28482 MK01_HUMAN Melanoma [ICD-11: 2C30]
P28482 MK01_HUMAN Pancreatic cancer [ICD-11: 2C10]
P28482 MK01_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P28482 MK01_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P28482 MK01_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P28482 MK01_HUMAN Transplant rejection [ICD-11: NE84]
P28482 MK01_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P28482 MK01_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P36544 ACHA7_HUMAN Corneal disease [ICD-11: 9A76-9A78]
P36544 ACHA7_HUMAN Schizophrenia [ICD-11: 6A20]
P36544 ACHA7_HUMAN Alzheimer disease [ICD-11: 8A20]
P36544 ACHA7_HUMAN Asthma [ICD-11: CA23]
P36544 ACHA7_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P36544 ACHA7_HUMAN General pain disorder [ICD-11: 8E43]
P36544 ACHA7_HUMAN Nicotine use disorder [ICD-11: 6C4A]
P36544 ACHA7_HUMAN Sexual dysfunction [ICD-11: HA00-HA01]
P36544 ACHA7_HUMAN Depression [ICD-11: 6A70-6A7Z]
P36544 ACHA7_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P36544 ACHA7_HUMAN Parkinsonism [ICD-11: 8A00]
P36544 ACHA7_HUMAN Adaptive immunity immunodeficiency [ICD-11: 4A01]
P36544 ACHA7_HUMAN Dissociative neurological symptom disorder [ICD-11: 6B60]
P36544 ACHA7_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
P36544 ACHA7_HUMAN Sex development malformative disorder [ICD-11: LD2A]
P36544 ACHA7_HUMAN Thrombosis [ICD-11: DB61-GB90]
P36544 ACHA7_HUMAN Attention deficit hyperactivity disorder [ICD-11: 6A05]
P36544 ACHA7_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]