Basic Information

Terpenoid ID TKC084630
Chirality TKC106232
Cell line 0
Protein target 31
DiseaseNCIT 0
ORDO 0
ICD 76

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC084630 HEK293 7943.0 nM Potency
TKC084630 HEK293 5802.0 nM Potency
TKC084630 SH-SY5Y SH-Sy5y; SHSY5Y; SHSY-5Y; SK-SH-SY5Y; SY5Y; SH-SY5Y Parental 35481.0 nM Potency C3270 Orphanet_635

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC084630 Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH2 1413 nM Potency
TKC084630 P04062 Lysosomal acid glucosylceramidase GBA1 25119 nM Potency
TKC084630 P10636 Microtubule-associated protein tau MAPT 19953 nM Potency
TKC084630 Q16637 Survival motor neuron protein SMN1,SMN2 35481 nM Potency
TKC084630 Q16637 Survival motor neuron protein SMN1,SMN2 35481 nM Potency
TKC084630 Q99700 Ataxin-2 ATXN2 31623 nM Potency
TKC084630 Q9UNA4 DNA polymerase iota POLI 14125 nM Potency
TKC084630 O75496 Geminin GMNN 12589 nM Potency
TKC084630 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 25119 nM Potency
TKC084630 P37840 Alpha-synuclein SNCA 6513 nM Potency
TKC084630 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 63096 nM Potency
TKC084630 P21728 D(1A) dopamine receptor DRD1 14125 nM Potency
TKC084630 P28482 Mitogen-activated protein kinase 1 MAPK1 39811 nM Potency
TKC084630 P83916 Chromobox protein homolog 1 CBX1 44668 nM Potency
TKC084630 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 50119 nM Potency
TKC084630 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 23100 nM Potency
TKC084630 P54132 Bloom syndrome protein BLM 141254 nM Potency
TKC084630 Q01453 Peripheral myelin protein 22 PMP22 23934 nM Potency
TKC084630 Q6W5P4 Neuropeptide S receptor NPSR1 19953 nM Potency
TKC084630 O00255 Menin MEN1 5012 nM Potency
TKC084630 P02791 Ferritin light chain FTL 6310 nM Potency
TKC084630 P49798 Regulator of G-protein signaling 4 RGS4 37686 nM Potency
TKC084630 Q03164 Histone-lysine N-methyltransferase 2A KMT2A 39811 nM Potency
TKC084630 Q9Y253 DNA polymerase eta POLH 22387 nM Potency
TKC084630 P02545 Prelamin-A/C LMNA 15849 nM Potency
TKC084630 O15118 NPC intracellular cholesterol transporter 1 NPC1 58048 nM Potency
TKC084630 P51151 Ras-related protein Rab-9A RAB9A 58048 nM Potency
TKC084630 P42345 Serine/threonine-protein kinase mTOR MTOR 3690 nM Potency
TKC084630 Q194T2 Non-structural protein 1 NS1 10000 nM Potency
TKC084630 P15289 Arylsulfatase A ARSA 37933 nM Potency
TKC084630 P0A6C1 Endonuclease 4 nfo 11220 nM Potency
TKC084630 Q99549 M-phase phosphoprotein 8 MPHOSPH8 70795 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q12809 KCNH2_HUMAN Heart failure [ICD-11: BD10-BD1Z]
Q12809 KCNH2_HUMAN Sleep-wake disorder [ICD-11: 7A00-7B2Z]
Q12809 KCNH2_HUMAN Malaria [ICD-11: 1F40-1F45]
Q12809 KCNH2_HUMAN Multiple sclerosis [ICD-11: 8A40]
Q12809 KCNH2_HUMAN Pain [ICD-11: MG30-MG3Z]
Q12809 KCNH2_HUMAN Cardiac arrhythmia [ICD-11: BC9Z]
Q12809 KCNH2_HUMAN Angina pectoris [ICD-11: BA40]
Q12809 KCNH2_HUMAN Genetic cardiac arrhythmia [ICD-11: BC65]
Q12809 KCNH2_HUMAN Ovarian cancer [ICD-11: 2C73]
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
P37840 SYUA_HUMAN Parkinsonism [ICD-11: 8A00]
P37840 SYUA_HUMAN Alzheimer disease [ICD-11: 8A20]
P37840 SYUA_HUMAN Autonomic nervous system disorder [ICD-11: 8D87]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P21728 DRD1_HUMAN Abortion [ICD-11: JA00]
P21728 DRD1_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P21728 DRD1_HUMAN Hypertension [ICD-11: BA00-BA04]
P21728 DRD1_HUMAN Parkinsonism [ICD-11: 8A00]
P21728 DRD1_HUMAN Cocaine use disorder [ICD-11: 6C45]
P21728 DRD1_HUMAN Schizophrenia [ICD-11: 6A20]
P21728 DRD1_HUMAN Tic disorder [ICD-11: 8A05]
P21728 DRD1_HUMAN Dementia [ICD-11: 6D80-6D8Z]
P21728 DRD1_HUMAN Psychotic disorder [ICD-11: 6A20-6A25]
P21728 DRD1_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P21728 DRD1_HUMAN Pain [ICD-11: MG30-MG3Z]
P21728 DRD1_HUMAN Glaucoma [ICD-11: 9C61]
P21728 DRD1_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
P21728 DRD1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P21728 DRD1_HUMAN Unspecific substance use disorder [ICD-11: 6C4Z]
P28482 MK01_HUMAN Melanoma [ICD-11: 2C30]
P28482 MK01_HUMAN Pancreatic cancer [ICD-11: 2C10]
P28482 MK01_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P28482 MK01_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P28482 MK01_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P28482 MK01_HUMAN Transplant rejection [ICD-11: NE84]
P28482 MK01_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P28482 MK01_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
P42345 MTOR_HUMAN Arteries/arterioles disorder [ICD-11: BD52]
P42345 MTOR_HUMAN Chronic myelomonocytic leukaemia [ICD-11: 2A40]
P42345 MTOR_HUMAN Hydrocephalus [ICD-11: 8D64]
P42345 MTOR_HUMAN Multiple myeloma [ICD-11: 2A83]
P42345 MTOR_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P42345 MTOR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P42345 MTOR_HUMAN Transplant rejection [ICD-11: NE84]
P42345 MTOR_HUMAN Sarcoma [ICD-11: 2A60-2C35]
P42345 MTOR_HUMAN Bladder cancer [ICD-11: 2C94]
P42345 MTOR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P42345 MTOR_HUMAN Endometrial cancer [ICD-11: 2C76]
P42345 MTOR_HUMAN Head and neck cancer [ICD-11: 2D42]
P42345 MTOR_HUMAN Liver cancer [ICD-11: 2C12]
P42345 MTOR_HUMAN Lung cancer [ICD-11: 2C25]
P42345 MTOR_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P42345 MTOR_HUMAN Malignant mesenchymal neoplasm [ICD-11: 2B5D-2B5Y]
P42345 MTOR_HUMAN Metastatic lymph node neoplasm [ICD-11: 2D60]
P42345 MTOR_HUMAN Pain [ICD-11: MG30-MG3Z]
P42345 MTOR_HUMAN Pancreatic cancer [ICD-11: 2C10]
P42345 MTOR_HUMAN Prostate cancer [ICD-11: 2C82]
P42345 MTOR_HUMAN Pulmonary hypertension [ICD-11: BB01]
P42345 MTOR_HUMAN Lymphangioleiomyomatosis [ICD-11: CB07]
P42345 MTOR_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P42345 MTOR_HUMAN Pleural mesothelioma [ICD-11: 2C26]
P42345 MTOR_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]
P42345 MTOR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P42345 MTOR_HUMAN Ulcerative colitis [ICD-11: DD71]
P15289 ARSA_HUMAN Lysosomal disease [ICD-11: 5C56]