Basic Information

Terpenoid ID TKC048308
Chirality TKC048341
Cell line 3
Protein target 4
DiseaseNCIT 3
ORDO 1
ICD 30

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC048308 A549 10000.0 nM IC50 C3512
TKC048308 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 10000.0 nM IC50 C9154 Orphanet_519
TKC048308 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 78.0 % Activity C60781 Orphanet_94
TKC048308 C6 C-6; C 6; RGC-6; RGC6; RGc6 97.0 % Activity C64069
TKC048308 PC-12 PC 12; PC12 10.0 % Activity C5650

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC048308 P0DTD1 Replicase polyprotein 1ab rep -3 % Inhibition
TKC048308 P11387 DNA topoisomerase 1 TOP1 >250000 nM IC50
TKC048308 P15121 Aldo-keto reductase family 1 member B1 AKR1B1 >200000 nM IC50
TKC048308 P11388 DNA topoisomerase 2-alpha TOP2A >250000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11387 TOP1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P11387 TOP1_HUMAN Colorectal cancer [ICD-11: 2B91]
P11387 TOP1_HUMAN Lung cancer [ICD-11: 2C25]
P11387 TOP1_HUMAN Ovarian cancer [ICD-11: 2C73]
P11387 TOP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11387 TOP1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P11387 TOP1_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P11387 TOP1_HUMAN Stomach cancer [ICD-11: 2B72]
P11387 TOP1_HUMAN Brain cancer [ICD-11: 2A00]
P11387 TOP1_HUMAN Esophageal cancer [ICD-11: 2B70]
P11387 TOP1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P11387 TOP1_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P11387 TOP1_HUMAN Gastrointestinal stromal tumour [ICD-11: 2B5B]
P11387 TOP1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P11387 TOP1_HUMAN Mature B-cell lymphoma [ICD-11: 2A85]
P11387 TOP1_HUMAN Bladder cancer [ICD-11: 2C94]
P15121 ALDR_HUMAN Neuropathy [ICD-11: 8C0Z]
P15121 ALDR_HUMAN Pain [ICD-11: MG30-MG3Z]
P15121 ALDR_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P15121 ALDR_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P15121 ALDR_HUMAN Thrombosis [ICD-11: DB61-GB90]
P15121 ALDR_HUMAN Cataract [ICD-11: 9B10]
P15121 ALDR_HUMAN Glaucoma [ICD-11: 9C61]
P15121 ALDR_HUMAN Schizophrenia [ICD-11: 6A20]
P15121 ALDR_HUMAN Gout [ICD-11: FA25]
P15121 ALDR_HUMAN Head and neck cancer [ICD-11: 2D42]
P11388 TOP2A_HUMAN Kaposi sarcoma [ICD-11: 2B57]
P11388 TOP2A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11388 TOP2A_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11388 TOP2A_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]