Basic Information

Terpenoid ID TKC041411
Chirality TKC026870
Cell line 0
Protein target 8
DiseaseNCIT 0
ORDO 0
ICD 14

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC041411 HT-22 HT-22 200.0 nM EC50
TKC041411 PC-12 PC 12; PC12 81.0 % Activity C5650
TKC041411 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 65.0 % Activity C7953 Orphanet_99861
TKC041411 MCF7 329000.0 nM IC50 C4194
TKC041411 HMEC 29.0 % Activity
TKC041411 A-431 A431; A431/P 1.0 ug ml-1 ED50 C4819
TKC041411 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 255000.0 nM IC50 C9154 Orphanet_519
TKC041411 HMEC-1 29.0 % Activity
TKC041411 SH-SY5Y SH-Sy5y; SHSY5Y; SHSY-5Y; SK-SH-SY5Y; SY5Y; SH-SY5Y Parental 7.0 % Activity C3270 Orphanet_635
TKC041411 RAW264.7 RAW264 53.0 % Activity C21604
TKC041411 Hep 3B2 Hep 3B2_1-7; HEP3B217; Hep 3B2; HEP-3B2; HEP3B2; Hep-3B; HEP-3B; Hep 3B; Hep3B; HEP3B 13.0 % Activity C7955 Orphanet_33402
TKC041411 NIH3T3 NIH/3T3; NIH-3T3; NIH3T3; 3T3; 3T3NIH; 3T3-Swiss; Swiss-3T3; Swiss/3T3; Swiss 3T3; Swiss3T3 11.0 % Activity

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC041411 P10636 Microtubule-associated protein tau MAPT 3548 nM Potency
TKC041411 O95398 Rap guanine nucleotide exchange factor 3 RAPGEF3 5012 nM Potency
TKC041411 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 3981 nM Potency
TKC041411 P0DTD1 Replicase polyprotein 1ab rep 16 % Inhibition
TKC041411 O00255 Menin MEN1 39811 nM Potency
TKC041411 P02545 Prelamin-A/C LMNA 112 nM Potency
TKC041411 P62826 GTP-binding nuclear protein Ran RAN 1458 nM Potency
TKC041411 P16662 UDP-glucuronosyltransferase 2B7 UGT2B7 0 pm/min/mg Activity
TKC041411 P04762 Catalase Cat 1 ug.mL-1 EC50
TKC041411 P08170 Seed linoleate 13S-lipoxygenase-1 LOX1.1 13 % Control
TKC041411 P09211 Glutathione S-transferase P GSTP1 500 nM IC50
TKC041411 P49638 Alpha-tocopherol transfer protein TTPA 2420 nM Kd
TKC041411 Q9NPH5 NADPH oxidase 4 NOX4 4 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
O95398 RPGF3_HUMAN Epidermal dysplasias [ICD-11: EK90]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P09211 GSTP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P09211 GSTP1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P09211 GSTP1_HUMAN Colorectal cancer [ICD-11: 2B91]
P09211 GSTP1_HUMAN Lung cancer [ICD-11: 2C25]
P09211 GSTP1_HUMAN Pancreatic cancer [ICD-11: 2C10]
Q9NPH5 NOX4_HUMAN Fibrosis [ICD-11: GA14-GC01]