Basic Information

Terpenoid ID TKC020987
Chirality TKC130327
Cell line 0
Protein target 6
DiseaseNCIT 0
ORDO 0
ICD 10

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC020987 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 668344.0 nM GI50 C2926
TKC020987 PC-3 PC3; PC.3 1000000.0 nM IC50 C4863
TKC020987 SN12C SN-12C 554626.0 nM GI50 C9385 Orphanet_217071
TKC020987 MDA-N MDAN 10000.0 nM GI50 C3802
TKC020987 ACHN 120504.0 nM GI50 C6975 Orphanet_319298
TKC020987 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 464515.0 nM GI50 C3512
TKC020987 UO-31 UO.31; UO31; U031 410204.0 nM GI50 C9385 Orphanet_217071
TKC020987 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 117490.0 nM GI50 C2926
TKC020987 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 10000.0 nM GI50 C4863
TKC020987 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 110408.0 nM GI50 C3510
TKC020987 SF-539 SF-539; SF-539 BT; SF.539; SF 539 501187.0 nM GI50 C3796 Orphanet_251576
TKC020987 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 324340.0 nM GI50 C3224
TKC020987 K562 K562; K.562; K 562; KO; GM05372; GM05372E 30479.0 nM GI50 C9110 Orphanet_521
TKC020987 A498 A498 548277.0 nM GI50 C9385 Orphanet_217071
TKC020987 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 149624.0 nM GI50 C105555
TKC020987 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 72277.0 nM GI50 C9142 Orphanet_99861
TKC020987 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 10000.0 nM GI50 C105555
TKC020987 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 184077.0 nM GI50 C3512
TKC020987 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 145211.0 nM GI50 C105555
TKC020987 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 124738.0 nM GI50 C60781 Orphanet_94
TKC020987 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 169434.0 nM GI50 C105555
TKC020987 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 10000.0 nM GI50 C5214
TKC020987 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 347536.0 nM GI50 C60781 Orphanet_94
TKC020987 SR SR-786; SR786 151705.0 nM GI50 C37193 Orphanet_300895
TKC020987 TK-10 TK.10; TK 10; TK10 324340.0 nM GI50 C4033 Orphanet_319276
TKC020987 M19-MEL M-19; M19 182390.0 nM GI50 C3802
TKC020987 SW-620 SW-620; SW 620; SW.620 636796.0 nM GI50 C4349
TKC020987 KM12 KM-12; KM.12 315500.0 nM GI50 C4910
TKC020987 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 344350.0 nM GI50 C3512
TKC020987 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 709578.0 nM GI50 C3802
TKC020987 XF498 XF-498; XF498 123310.0 nM GI50 C3058 Orphanet_360
TKC020987 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 292415.0 nM GI50 C2923
TKC020987 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 10000.0 nM GI50 C3242 Orphanet_29073
TKC020987 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 515229.0 nM GI50 C105555
TKC020987 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 194984.0 nM GI50 C3802
TKC020987 BT-549 BT 549; BT.549; BT549 10000.0 nM GI50 C4194
TKC020987 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 121899.0 nM GI50 C3224
TKC020987 KM-20L2 KM-20L2; KM 20L2; KM 2012 264850.0 nM GI50 C4349
TKC020987 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 753356.0 nM GI50 C4349
TKC020987 A549 350000.0 nM IC50 C3512
TKC020987 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 55976.0 nM GI50 C3058 Orphanet_360
TKC020987 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 96161.0 nM GI50 C4910
TKC020987 HCT-15 HCT-15; HCT.15; HCT15 166725.0 nM GI50 C4349
TKC020987 EKVX 616595.0 nM GI50 C3512
TKC020987 SF-268 SF-268; SF.268; SF 268 84140.0 nM GI50 C60781 Orphanet_94
TKC020987 MCF7 1000000.0 nM IC50 C4194
TKC020987 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 123595.0 nM GI50 C4917 Orphanet_70573
TKC020987 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 748170.0 nM GI50 C7978
TKC020987 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 453942.0 nM GI50 C4450
TKC020987 T47D 10000.0 nM GI50 C4194
TKC020987 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 235505.0 nM GI50 C3224
TKC020987 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 10000.0 nM GI50 C3224
TKC020987 SF-295 SF-295; SF.295; SF 295 266073.0 nM GI50 C3058 Orphanet_360
TKC020987 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 10000.0 nM GI50 C3802
TKC020987 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 574116.0 nM GI50 C7979 Orphanet_454723
TKC020987 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 194984.0 nM GI50 C9385 Orphanet_217071
TKC020987 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 10000.0 nM GI50 C4194
TKC020987 RXF 631 RXF-631L; RXF631L; RXF 631; RXF-631; RXF631 564937.0 nM GI50 C9385 Orphanet_217071
TKC020987 SNB-78 SNB78; Surgical Neurology Branch-78 199526.0 nM GI50 C3058 Orphanet_360
TKC020987 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 533335.0 nM GI50 C3224
TKC020987 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 101158.0 nM GI50 C7953 Orphanet_99861
TKC020987 DLD-1 DLD 1; DLD1; CoCL3 220293.0 nM GI50 C4349
TKC020987 HT-29 HT 29; HT29 135831.0 nM GI50 C4349
TKC020987 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 250611.0 nM GI50 C45662 Orphanet_50251
TKC020987 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 93756.0 nM GI50 C9385 Orphanet_217071
TKC020987 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 1000000.0 nM IC50 C3510
TKC020987 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 198609.0 nM GI50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC020987 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 91 % Inhibition
TKC020987 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 84 % Inhibition
TKC020987 P53350 Serine/threonine-protein kinase PLK1 PLK1 23778 nM Potency
TKC020987 O75496 Geminin GMNN 164 nM Potency
TKC020987 Q13148 TAR DNA-binding protein 43 TARDBP 31623 nM Potency
TKC020987 P0DTD1 Replicase polyprotein 1ab rep 0 % Inhibition
TKC020987 P02791 Ferritin light chain FTL 44668 nM Potency
TKC020987 P16050 Polyunsaturated fatty acid lipoxygenase ALOX15 ALOX15 12589 nM Potency
TKC020987 Q16678 Cytochrome P450 1B1 CYP1B1 2000 nM Ki

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P53350 PLK1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P53350 PLK1_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P53350 PLK1_HUMAN Prostate cancer [ICD-11: 2C82]
P53350 PLK1_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P53350 PLK1_HUMAN Pancreatic cancer [ICD-11: 2C10]
P53350 PLK1_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P53350 PLK1_HUMAN Nasopharyngeal cancer [ICD-11: 2B6B]
P53350 PLK1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]