Basic Information

Terpenoid ID TKC012929
Chirality TKC105356
Cell line 0
Protein target 16
DiseaseNCIT 0
ORDO 0
ICD 45

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC012929 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 1.0 nM min-1 ml-1 Activity C9154 Orphanet_519
TKC012929 Raji RAJI; P1-Raji; GM04671 50.0 % Activity C27694 Orphanet_543
TKC012929 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 5700.0 nM CC50
TKC012929 MCF7 120.0 % Activity C4194

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC012929 P10636 Microtubule-associated protein tau MAPT 19953 nM Potency
TKC012929 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 63096 nM Potency
TKC012929 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 891 nM Potency
TKC012929 Q9UBT6 DNA polymerase kappa POLK 39811 nM Potency
TKC012929 O42275 Acetylcholinesterase ache 20 % Inhibition
TKC012929 P0DTD1 Replicase polyprotein 1ab rep 12 % Inhibition
TKC012929 P17252 Protein kinase C alpha type PRKCA 3 nM Ki
TKC012929 P17252 Protein kinase C alpha type PRKCA 6.4 nM Ki
TKC012929 P17252 Protein kinase C alpha type PRKCA 1700000 nM EC50
TKC012929 P17252 Protein kinase C alpha type PRKCA 9.5 nM EC50
TKC012929 P81908 Cholinesterase BCHE -6 % Inhibition
TKC012929 Q01196 Runt-related transcription factor 1 RUNX1 3162 nM Potency
TKC012929 P08659 Luciferin 4-monooxygenase 10 nM EC50
TKC012929 O94806 Serine/threonine-protein kinase D3 PRKD3 10 nM EC50
TKC012929 P11021 Endoplasmic reticulum chaperone BiP HSPA5 10000 nM Potency
TKC012929 P51450 Nuclear receptor ROR-gamma Rorc 10000 nM Potency
TKC012929 P05771 Protein kinase C beta type PRKCB 2 nM Ki
TKC012929 Q04759 Protein kinase C theta type PRKCQ 3190 nM EC50
TKC012929 Q05655 Protein kinase C delta type PRKCD 1 nM Ki
TKC012929 Q05655 Protein kinase C delta type PRKCD 5170 nM EC50
TKC012929 Q05655 Protein kinase C delta type PRKCD 290 nM EC50
TKC012929 P05129 Protein kinase C gamma type PRKCG 5 nM Ki
TKC012929 Q02156 Protein kinase C epsilon type PRKCE 0 nM Ki
TKC012929 Q02156 Protein kinase C epsilon type PRKCE 5560 nM EC50
TKC012929 Q8IV61 Ras guanyl-releasing protein 3 RASGRP3 82 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
P17252 KPCA_HUMAN Lung cancer [ICD-11: 2C25]
P17252 KPCA_HUMAN Muscular atrophy [ICD-11: 8B61]
P17252 KPCA_HUMAN Transplant rejection [ICD-11: NE84]
P17252 KPCA_HUMAN Nephritic syndrome [ICD-11: GB40]
P17252 KPCA_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P17252 KPCA_HUMAN Lung cancer [ICD-11: 2C25]
P17252 KPCA_HUMAN Muscular atrophy [ICD-11: 8B61]
P17252 KPCA_HUMAN Transplant rejection [ICD-11: NE84]
P17252 KPCA_HUMAN Nephritic syndrome [ICD-11: GB40]
P17252 KPCA_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P17252 KPCA_HUMAN Lung cancer [ICD-11: 2C25]
P17252 KPCA_HUMAN Muscular atrophy [ICD-11: 8B61]
P17252 KPCA_HUMAN Transplant rejection [ICD-11: NE84]
P17252 KPCA_HUMAN Nephritic syndrome [ICD-11: GB40]
P17252 KPCA_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P17252 KPCA_HUMAN Lung cancer [ICD-11: 2C25]
P17252 KPCA_HUMAN Muscular atrophy [ICD-11: 8B61]
P17252 KPCA_HUMAN Transplant rejection [ICD-11: NE84]
P17252 KPCA_HUMAN Nephritic syndrome [ICD-11: GB40]
P17252 KPCA_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P11021 BIP_HUMAN Melanoma [ICD-11: 2C30]
P11021 BIP_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P05771 KPCB_HUMAN Brain cancer [ICD-11: 2A00]
P05771 KPCB_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P05771 KPCB_HUMAN Diffuse large B-cell lymphoma [ICD-11: 2A81]
P05771 KPCB_HUMAN Lymphoma [ICD-11: 2A80-2A86]
P05771 KPCB_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P05771 KPCB_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P05771 KPCB_HUMAN Transplant rejection [ICD-11: NE84]
P05771 KPCB_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P05771 KPCB_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P05771 KPCB_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q04759 KPCT_HUMAN Transplant rejection [ICD-11: NE84]
Q04759 KPCT_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q04759 KPCT_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q05655 KPCD_HUMAN Myocardial infarction [ICD-11: BA41-BA43]
Q05655 KPCD_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q05655 KPCD_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q05655 KPCD_HUMAN Myocardial infarction [ICD-11: BA41-BA43]
Q05655 KPCD_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q05655 KPCD_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q05655 KPCD_HUMAN Myocardial infarction [ICD-11: BA41-BA43]
Q05655 KPCD_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q05655 KPCD_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
P05129 KPCG_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P05129 KPCG_HUMAN Chronic myelomonocytic leukaemia [ICD-11: 2A40]
P05129 KPCG_HUMAN Colorectal cancer [ICD-11: 2B91]
P05129 KPCG_HUMAN Mastocytosis [ICD-11: 2A21]
P05129 KPCG_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q02156 KPCE_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
Q02156 KPCE_HUMAN Liver vascular disorder [ICD-11: DB98]
Q02156 KPCE_HUMAN Malaria [ICD-11: 1F40-1F45]
Q02156 KPCE_HUMAN Alzheimer disease [ICD-11: 8A20]
Q02156 KPCE_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q02156 KPCE_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]
Q02156 KPCE_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
Q02156 KPCE_HUMAN Liver vascular disorder [ICD-11: DB98]
Q02156 KPCE_HUMAN Malaria [ICD-11: 1F40-1F45]
Q02156 KPCE_HUMAN Alzheimer disease [ICD-11: 8A20]
Q02156 KPCE_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q02156 KPCE_HUMAN Human immunodeficiency virus disease [ICD-11: 1C60-1C62]