Basic Information

Terpenoid ID TKC011921
Chirality TKC104764
Cell line 0
Protein target 14
DiseaseNCIT 0
ORDO 0
ICD 19

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC011921 H4 H-4 73.0 % Activity C60781 Orphanet_94
TKC011921 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 580.0 nM IC50
TKC011921 HEK293 731.0 nM Potency
TKC011921 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 9000.0 nM IC50 C4910
TKC011921 HL Human Lung 92.0 % Activity
TKC011921 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 24400.0 nM IC50 C9154 Orphanet_519

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC011921 Q16637 Survival motor neuron protein SMN1,SMN2 794 nM Potency
TKC011921 Q16637 Survival motor neuron protein SMN1,SMN2 794 nM Potency
TKC011921 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 104 nM Potency
TKC011921 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 39811 nM Potency
TKC011921 O42275 Acetylcholinesterase ache 8 % Inhibition
TKC011921 P0DTD1 Replicase polyprotein 1ab rep 11 % Inhibition
TKC011921 P81908 Cholinesterase BCHE 13 % Inhibition
TKC011921 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 6310 nM Potency
TKC011921 P46063 ATP-dependent DNA helicase Q1 RECQL 5623 nM Potency
TKC011921 P06746 DNA polymerase beta POLB >100000 nM IC50
TKC011921 Q16665 Hypoxia-inducible factor 1-alpha HIF1A 1995 nM Potency
TKC011921 P02545 Prelamin-A/C LMNA 794 nM Potency
TKC011921 P04292 DNA polymerase catalytic subunit UL30 438 nM IC50
TKC011921 P04292 DNA polymerase catalytic subunit UL30 500 nM IC50
TKC011921 P06766 DNA polymerase beta Polb >100000 nM IC50
TKC011921 P08546 DNA polymerase catalytic subunit UL54 400 nM IC50
TKC011921 P08546 DNA polymerase catalytic subunit UL54 487 nM IC50
TKC011921 P09252 DNA polymerase catalytic subunit ORF28 600 nM IC50
TKC011921 P09884 DNA polymerase alpha catalytic subunit POLA1 2000 nM EC50
TKC011921 P09884 DNA polymerase alpha catalytic subunit POLA1 3000 nM IC50
TKC011921 P09884 DNA polymerase alpha catalytic subunit POLA1 2600 nM IC50
TKC011921 P09884 DNA polymerase alpha catalytic subunit POLA1 2600 nM IC50
TKC011921 P09884 DNA polymerase alpha catalytic subunit POLA1 16000 nM IC50
TKC011921 P09884 DNA polymerase alpha catalytic subunit POLA1 2400 nM IC50
TKC011921 P28340 DNA polymerase delta catalytic subunit POLD1 >40000 nM IC50
TKC011921 P28857 DNA polymerase catalytic subunit U38 400 nM IC50
TKC011921 P42858 Huntingtin HTT 631 nM Potency
TKC011921 P54098 DNA polymerase subunit gamma-1 POLG >100000 nM IC50
TKC011921 Q9UGP5 DNA polymerase lambda POLL >200000 nM IC50
TKC011921 Q13285 Steroidogenic factor 1 NR5A1 550 nM IC50
TKC011921 Q13285 Steroidogenic factor 1 NR5A1 519 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P06746 DPOLB_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q16665 HIF1A_HUMAN Brain cancer [ICD-11: 2A00]
Q16665 HIF1A_HUMAN Lymphoma [ICD-11: 2A80-2A86]
Q16665 HIF1A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Pulmonary hypertension [ICD-11: BB01]
P08546 DPOL_HCMVA Cytomegaloviral disease [ICD-11: 1D82]
P08546 DPOL_HCMVA Cytomegaloviral disease [ICD-11: 1D82]
P09252 DPOL_VZVD Herpes simplex infection [ICD-11: 1F00]
P09252 DPOL_VZVD Virus infection [ICD-11: 1A24-1D9Z]
P09884 DPOLA_HUMAN Virus infection [ICD-11: 1A24-1D9Z]
P09884 DPOLA_HUMAN Virus infection [ICD-11: 1A24-1D9Z]
P09884 DPOLA_HUMAN Virus infection [ICD-11: 1A24-1D9Z]
P09884 DPOLA_HUMAN Virus infection [ICD-11: 1A24-1D9Z]
P09884 DPOLA_HUMAN Virus infection [ICD-11: 1A24-1D9Z]
P09884 DPOLA_HUMAN Virus infection [ICD-11: 1A24-1D9Z]
P42858 HD_HUMAN Choreiform disorder [ICD-11: 8A01]