Basic Information

Terpenoid ID TKC206890
Chirality TKC117994
Cell line 0
Protein target 3
DiseaseNCIT 0
ORDO 0
ICD 6

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC206890 MCF7 1.0 ug ml-1 ED50 C4194
TKC206890 KB KB (HeLa derivative); HeLa-KB; Strain KB 2.0 ug ml-1 ED50 C27677
TKC206890 Bel-7402 Bel-7402; BEL 7402; Bel 7402; BEL7402; Bel7402 50.0 nM IC50 C27677
TKC206890 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 10.0 nM GI50 C4910
TKC206890 UO-31 UO.31; UO31; U031 10.0 nM GI50 C9385 Orphanet_217071
TKC206890 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 18.0 nM GI50 C60781 Orphanet_94
TKC206890 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 15.0 nM GI50 C3802
TKC206890 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 10.0 nM GI50 C4349
TKC206890 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 10.0 nM GI50 C7979 Orphanet_454723
TKC206890 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 10.0 nM GI50 C4194
TKC206890 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 10.0 nM GI50 C7953 Orphanet_99861

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206890 Q16637 Survival motor neuron protein SMN1,SMN2 224 nM Potency
TKC206890 Q16637 Survival motor neuron protein SMN1,SMN2 224 nM Potency
TKC206890 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 326 nM Potency
TKC206890 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 96 % Inhibition
TKC206890 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 102 % Inhibition
TKC206890 Q16665 Hypoxia-inducible factor 1-alpha HIF1A 20 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16665 HIF1A_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q16665 HIF1A_HUMAN Brain cancer [ICD-11: 2A00]
Q16665 HIF1A_HUMAN Lymphoma [ICD-11: 2A80-2A86]
Q16665 HIF1A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Pulmonary hypertension [ICD-11: BB01]