Basic Information
| Terpenoid ID | TKC206876 |
|
| Chirality | TKC117625 | |
| Cell line | 0 | |
| Protein target | 12 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 48 |
| Terpenoid ID | TKC206876 |
|
| Chirality | TKC117625 | |
| Cell line | 0 | |
| Protein target | 12 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 48 |
| ID | Cell Line | Synonyms | Value | Unit | Type | NCIt | ORDO |
|---|---|---|---|---|---|---|---|
| TKC206876 | SW-620 | SW-620; SW 620; SW.620 | 3184.0 | nM | GI50 | C4349 | |
| TKC206876 | TK-10 | TK.10; TK 10; TK10 | 416.0 | nM | IC50 | C4033 | Orphanet_319276 |
| TKC206876 | MCF7 | 1806.0 | nM | IC50 | C4194 | ||
| TKC206876 | UACC-62 | UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 | 2618.0 | nM | GI50 | C3224 | |
| TKC206876 | HCT-116 | HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 | 63.0 | % | Survival | C4910 | |
| TKC206876 | HT-29 | HT 29; HT29 | 81.0 | % | Survival | C4349 | |
| TKC206876 | HepG2 | 4467.0 | nM | Potency | C3728 | Orphanet_449 | |
| TKC206876 | HEK293 | 3162.0 | nM | Potency | |||
| TKC206876 | MDA-N | MDAN | 2421.0 | nM | GI50 | C3802 | |
| TKC206876 | SN12C | SN-12C | 566.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC206876 | NCI-H23 | NCI.H23; NCI H23; H-23; H23; NCIH23 | 682.0 | nM | GI50 | C3512 | |
| TKC206876 | UO-31 | UO.31; UO31; U031 | 914.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC206876 | ACHN | 451.0 | nM | GI50 | C6975 | Orphanet_319298 | |
| TKC206876 | HL-60 | HL 60; HL.60 HL60; Human Leukemia-60 | 1622.0 | nM | GI50 | C9154 | Orphanet_519 |
| TKC206876 | HOP-92 | HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 | 9661.0 | nM | GI50 | C2926 | |
| TKC206876 | SF-539 | SF-539; SF-539 BT; SF.539; SF 539 | 849.0 | nM | GI50 | C3796 | Orphanet_251576 |
| TKC206876 | DU-145 | DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 | 1038.0 | nM | GI50 | C4863 | |
| TKC206876 | SK-MEL-5 | SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel | 1297.0 | nM | GI50 | C3510 | |
| TKC206876 | Malme-3M | MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer | 1766.0 | nM | GI50 | C3224 | |
| TKC206876 | K562 | K562; K.562; K 562; KO; GM05372; GM05372E | 3381.0 | nM | GI50 | C9110 | Orphanet_521 |
| TKC206876 | OVCAR-3 | Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 | 457.0 | nM | GI50 | C105555 | |
| TKC206876 | A498 | A498 | 2723.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC206876 | HOP-62 | HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 | 1109.0 | nM | GI50 | C3512 | |
| TKC206876 | MOLT-4 | Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D | 408.0 | nM | GI50 | C9142 | Orphanet_99861 |
| TKC206876 | NCI/ADR-RES | NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR | 1614.0 | nM | GI50 | C105555 | |
| TKC206876 | U-251 | U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) | 2223.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC206876 | OVCAR-5 | OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 | 2805.0 | nM | GI50 | C105555 | |
| TKC206876 | OVCAR-8 | OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 | 2931.0 | nM | GI50 | C105555 | |
| TKC206876 | SNB-19 | SNB.19; SNB19; Surgical Neurology Branch-19 | 4446.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC206876 | SR | SR-786; SR786 | 977.0 | nM | GI50 | C37193 | Orphanet_300895 |
| TKC206876 | MDA-MB-231 | MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 | 4932.0 | nM | GI50 | C5214 | |
| TKC206876 | NCI-H522 | NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 | 435.0 | nM | GI50 | C3512 | |
| TKC206876 | M14 | M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 | 2449.0 | nM | GI50 | C3802 | |
| TKC206876 | KM12 | KM-12; KM.12 | 4853.0 | nM | GI50 | C4910 | |
| TKC206876 | NCI-H322M | NCI.H322M; H322M; H-322M; H-322m | 1791.0 | nM | GI50 | C2923 | |
| TKC206876 | RPMI-8226 | RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson | 2773.0 | nM | GI50 | C3242 | Orphanet_29073 |
| TKC206876 | OVCAR-4 | OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 | 1396.0 | nM | GI50 | C105555 | |
| TKC206876 | BT-549 | BT 549; BT.549; BT549 | 1892.0 | nM | GI50 | C4194 | |
| TKC206876 | LOX IMVI | LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX | 2897.0 | nM | GI50 | C3802 | |
| TKC206876 | SK-MEL-2 | SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 | 2173.0 | nM | GI50 | C3224 | |
| TKC206876 | A549 | 445.0 | nM | GI50 | C3512 | ||
| TKC206876 | HCC 2998 | HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 | 2466.0 | nM | GI50 | C4349 | |
| TKC206876 | SNB-75 | SNB.75; SNB75; Surgical Neurology Branch-75 | 4150.0 | nM | GI50 | C3058 | Orphanet_360 |
| TKC206876 | HCT-15 | HCT-15; HCT.15; HCT15 | 2582.0 | nM | GI50 | C4349 | |
| TKC206876 | SF-268 | SF-268; SF.268; SF 268 | 845.0 | nM | GI50 | C60781 | Orphanet_94 |
| TKC206876 | EKVX | 785.0 | nM | GI50 | C3512 | ||
| TKC206876 | PC-3 | PC3; PC.3 | 1442.0 | nM | GI50 | C4863 | |
| TKC206876 | SK-OV-3 | SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 | 2710.0 | nM | GI50 | C7978 | |
| TKC206876 | T47D | 3648.0 | nM | GI50 | C4194 | ||
| TKC206876 | NCI-H460 | NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 | 499.0 | nM | GI50 | C4450 | |
| TKC206876 | MDA-MB-435 | MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 | 3006.0 | nM | GI50 | C3802 | |
| TKC206876 | CAKI-1 | CAL 1; Centre Antoine Lacassagne-1 | 1581.0 | nM | GI50 | C3224 | |
| TKC206876 | SF-295 | SF-295; SF.295; SF 295 | 1413.0 | nM | GI50 | C3058 | Orphanet_360 |
| TKC206876 | Hs-578T | HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells | 968.0 | nM | GI50 | C4194 | |
| TKC206876 | IGROV-1 | Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P | 2864.0 | nM | GI50 | C7979 | Orphanet_454723 |
| TKC206876 | 786-0 | 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT | 995.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC206876 | UACC-257 | UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 | 2203.0 | nM | GI50 | C3224 | |
| TKC206876 | CCRF-CEM | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C | 511.0 | nM | GI50 | C7953 | Orphanet_99861 |
| TKC206876 | NCI-H226 | NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 | 3119.0 | nM | GI50 | C45662 | Orphanet_50251 |
| TKC206876 | SK-MEL-28 | SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 | 5129.0 | nM | GI50 | C3510 | |
| TKC206876 | RXF 393 | RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL | 1151.0 | nM | GI50 | C9385 | Orphanet_217071 |
| TKC206876 | COLO 205 | Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 | 2612.0 | nM | GI50 | C4349 |
| ID | Uniport | Pref_name | Gene name | value | unit | type |
|---|---|---|---|---|---|---|
| TKC206876 | P11473 | Vitamin D3 receptor | VDR | 79433 | nM | Potency |
| TKC206876 | Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | 5174 | nM | Potency |
| TKC206876 | O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | IDH1 | 4611 | nM | Potency |
| TKC206876 | P43220 | Glucagon-like peptide 1 receptor | GLP1R | 5012 | nM | Potency |
| TKC206876 | P84022 | Mothers against decapentaplegic homolog 3 | SMAD3 | 10000 | nM | Potency |
| TKC206876 | Q16236 | Nuclear factor erythroid 2-related factor 2 | NFE2L2 | 1636 | nM | Potency |
| TKC206876 | Q99700 | Ataxin-2 | ATXN2 | 2239 | nM | Potency |
| TKC206876 | O75496 | Geminin | GMNN | 2060 | nM | Potency |
| TKC206876 | O42275 | Acetylcholinesterase | ache | -2 | % | Inhibition |
| TKC206876 | P81908 | Cholinesterase | BCHE | 2 | % | Inhibition |
| TKC206876 | Q96QE3 | ATPase family AAA domain-containing protein 5 | ATAD5 | 2059 | nM | Potency |
| TKC206876 | P51151 | Ras-related protein Rab-9A | RAB9A | 5012 | nM | Potency |
| TKC206876 | P16473 | Thyrotropin receptor | TSHR | 1346 | nM | Potency |
| TKC206876 | Q9HYR3 | Uncharacterized PhzA/B-like protein PA3332 | PA3332 | 3250 | nM | Kd |
| Uniport ID | Uniport Name | ICD-11 |
|---|---|---|
| P11473 | VDR_HUMAN | Chronic kidney disease [ICD-11: GB61] |
| P11473 | VDR_HUMAN | Hair/hair growth developmental defect [ICD-11: LC30] |
| P11473 | VDR_HUMAN | Hyper-parathyroidism [ICD-11: 5A51] |
| P11473 | VDR_HUMAN | Hypo-parathyroidism [ICD-11: 5A50] |
| P11473 | VDR_HUMAN | Mineral deficiency [ICD-11: 5B5K] |
| P11473 | VDR_HUMAN | Psoriasis [ICD-11: EA90] |
| P11473 | VDR_HUMAN | Vitamin deficiency [ICD-11: 5B55-5B5F] |
| P11473 | VDR_HUMAN | Low bone mass disorder [ICD-11: FB83] |
| P11473 | VDR_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| P11473 | VDR_HUMAN | Prostate cancer [ICD-11: 2C82] |
| P11473 | VDR_HUMAN | Prostate disease [ICD-11: GA91] |
| P11473 | VDR_HUMAN | Abnormal micturition [ICD-11: MF50] |
| P11473 | VDR_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P11473 | VDR_HUMAN | Postoperative inflammation [ICD-11: 1A00-CA43] |
| P11473 | VDR_HUMAN | Acne vulgaris [ICD-11: ED80] |
| O75874 | IDHC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| O75874 | IDHC_HUMAN | Liver cancer [ICD-11: 2C12] |
| O75874 | IDHC_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| O75874 | IDHC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| O75874 | IDHC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| O75874 | IDHC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P43220 | GLP1R_HUMAN | Cardiovascular disease [ICD-11: BA00-BE2Z] |
| P43220 | GLP1R_HUMAN | Obesity [ICD-11: 5B80-5B81] |
| P43220 | GLP1R_HUMAN | Type 2 diabetes mellitus [ICD-11: 5A11] |
| P43220 | GLP1R_HUMAN | Type-1/2 diabete [ICD-11: 5A10-5A11] |
| P43220 | GLP1R_HUMAN | Acute diabete complication [ICD-11: 5A2Y] |
| P43220 | GLP1R_HUMAN | Diabetes mellitus [ICD-11: 5A10] |
| P43220 | GLP1R_HUMAN | Dyspepsia [ICD-11: MD92] |
| P43220 | GLP1R_HUMAN | Irritable bowel syndrome [ICD-11: DD91] |
| P43220 | GLP1R_HUMAN | Intracranial injury [ICD-11: NA07] |
| P43220 | GLP1R_HUMAN | Non-alcoholic fatty liver disease [ICD-11: DB92] |
| P84022 | SMAD3_HUMAN | Herpes simplex infection [ICD-11: 1F00] |
| P84022 | SMAD3_HUMAN | Kidney fibrosis [ICD-11: GC01] |
| Q16236 | NF2L2_HUMAN | Ataxic disorder [ICD-11: 8A03] |
| Q16236 | NF2L2_HUMAN | Breast cancer [ICD-11: 2C60-2C6Y] |
| Q16236 | NF2L2_HUMAN | Glaucoma [ICD-11: 9C61] |
| Q16236 | NF2L2_HUMAN | Lung cancer [ICD-11: 2C25] |
| Q16236 | NF2L2_HUMAN | Macular degeneration [ICD-11: 9B75] |
| Q16236 | NF2L2_HUMAN | Melanoma [ICD-11: 2C30] |
| Q16236 | NF2L2_HUMAN | Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z] |
| Q16236 | NF2L2_HUMAN | Pulmonary hypertension [ICD-11: BB01] |
| Q16236 | NF2L2_HUMAN | Subarachnoid haemorrhage [ICD-11: 8B01] |
| Q16236 | NF2L2_HUMAN | Urinary system clinical sympton [ICD-11: MF8Y] |
| Q16236 | NF2L2_HUMAN | Non-alcoholic fatty liver disease [ICD-11: DB92] |
| Q16236 | NF2L2_HUMAN | Alpha-1-antitrypsin deficiency [ICD-11: 5C5A] |
| Q16236 | NF2L2_HUMAN | Motor neuron disease [ICD-11: 8B60] |
| Q16236 | NF2L2_HUMAN | Multiple sclerosis [ICD-11: 8A40] |
| P51151 | RAB9A_HUMAN | Fungal infection [ICD-11: 1F29-1F2F] |
| P16473 | TSHR_HUMAN | Hypo-thyroidism [ICD-11: 5A00] |
| P16473 | TSHR_HUMAN | Thyroid cancer [ICD-11: 2D10] |