Basic Information

Terpenoid ID TKC206872
Cell line 0
Protein target 27
DiseaseNCIT 0
ORDO 0
ICD 82

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC206872 TK-10 TK.10; TK 10; TK10 318.0 nM IC50 C4033 Orphanet_319276
TKC206872 MCF7 507.0 nM IC50 C4194
TKC206872 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 416.0 nM IC50 C3224
TKC206872 HepG2 1259.0 nM Potency C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206872 Q16637 Survival motor neuron protein SMN1,SMN2 10000 nM Potency
TKC206872 Q16637 Survival motor neuron protein SMN1,SMN2 10000 nM Potency
TKC206872 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 0 nM Potency
TKC206872 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 2060 nM Potency
TKC206872 P43220 Glucagon-like peptide 1 receptor GLP1R 501 nM Potency
TKC206872 P84022 Mothers against decapentaplegic homolog 3 SMAD3 10000 nM Potency
TKC206872 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 767 nM Potency
TKC206872 Q06710 Paired box protein Pax-8 PAX8 2350 nM AC50
TKC206872 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 461 nM Potency
TKC206872 Q99700 Ataxin-2 ATXN2 1122 nM Potency
TKC206872 O75164 Lysine-specific demethylase 4A KDM4A 79433 nM Potency
TKC206872 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 200 nM Potency
TKC206872 O75496 Geminin GMNN 920 nM Potency
TKC206872 P0DTD1 Replicase polyprotein 1ab rep -6 % Inhibition
TKC206872 P33261 Cytochrome P450 2C19 CYP2C19 10000 nM Potency
TKC206872 P83916 Chromobox protein homolog 1 CBX1 100000 nM Potency
TKC206872 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 1413 nM Potency
TKC206872 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 16 nM Potency
TKC206872 Q16665 Hypoxia-inducible factor 1-alpha HIF1A 1000 nM Potency
TKC206872 P05023 Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1 139 nM Ki
TKC206872 P02545 Prelamin-A/C LMNA 224 nM Potency
TKC206872 P15917 Lethal factor lef 25119 nM Potency
TKC206872 O15118 NPC intracellular cholesterol transporter 1 NPC1 3981 nM Potency
TKC206872 P51151 Ras-related protein Rab-9A RAB9A 2512 nM Potency
TKC206872 P04637 Cellular tumor antigen p53 TP53 631 nM Potency
TKC206872 Q8WZA2 Rap guanine nucleotide exchange factor 4 RAPGEF4 10000 nM Potency
TKC206872 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 19 % Activity
TKC206872 Q6ZQN7 Solute carrier organic anion transporter family member 4C1 SLCO4C1 490 nM IC50
TKC206872 Q6ZQN7 Solute carrier organic anion transporter family member 4C1 SLCO4C1 490 nM IC50
TKC206872 P50993 Sodium/potassium-transporting ATPase subunit alpha-2 ATP1A2 130 nM Ki
TKC206872 Q9HYR3 Uncharacterized PhzA/B-like protein PA3332 PA3332 474 nM Kd

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
Q16665 HIF1A_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q16665 HIF1A_HUMAN Brain cancer [ICD-11: 2A00]
Q16665 HIF1A_HUMAN Lymphoma [ICD-11: 2A80-2A86]
Q16665 HIF1A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Pulmonary hypertension [ICD-11: BB01]
P05023 AT1A1_HUMAN Cardiac arrhythmia [ICD-11: BC9Z]
P05023 AT1A1_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P05023 AT1A1_HUMAN Corneal disease [ICD-11: 9A76-9A78]
P05023 AT1A1_HUMAN Heart failure [ICD-11: BD10-BD1Z]
P05023 AT1A1_HUMAN Hyperhidrosis [ICD-11: EE00]
P05023 AT1A1_HUMAN Malaria [ICD-11: 1F40-1F45]
P05023 AT1A1_HUMAN Supraventricular tachyarrhythmia [ICD-11: BC81]
P05023 AT1A1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P15917 LEF_BACAN Sepsis [ICD-11: 1G40-1G41]
P15917 LEF_BACAN Corneal disease [ICD-11: 9A76-9A78]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
P04637 P53_HUMAN Arterial occlusive disease [ICD-11: BD40]
P04637 P53_HUMAN Lip/oral cavity/pharynx neoplasm [ICD-11: 2B6E]
P04637 P53_HUMAN Metastatic liver/bile duct neoplasm [ICD-11: 2D80]
P04637 P53_HUMAN Transplant rejection [ICD-11: NE84]
P04637 P53_HUMAN Ovarian dysfunction [ICD-11: 5A80]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Bladder cancer [ICD-11: 2C94]
P04637 P53_HUMAN Brain cancer [ICD-11: 2A00]
P04637 P53_HUMAN Colorectal cancer [ICD-11: 2B91]
P04637 P53_HUMAN Esophageal cancer [ICD-11: 2B70]
P04637 P53_HUMAN Head and neck cancer [ICD-11: 2D42]
P04637 P53_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P04637 P53_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
P04637 P53_HUMAN Ovarian cancer [ICD-11: 2C73]
P04637 P53_HUMAN Pancreatic cancer [ICD-11: 2C10]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Stomach cancer [ICD-11: 2B72]
P04637 P53_HUMAN Cervical cancer [ICD-11: 2C77]
P04637 P53_HUMAN Endometrial cancer [ICD-11: 2C76]
P04637 P53_HUMAN Fallopian tube cancer [ICD-11: 2C74]
P04637 P53_HUMAN Liposarcoma [ICD-11: 2B59]
P04637 P53_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P04637 P53_HUMAN Peritoneal cancer [ICD-11: 2C51]
P04637 P53_HUMAN Toxicity [ICD-11: N.A.]
P04637 P53_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04637 P53_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P04637 P53_HUMAN Kidney failure [ICD-11: GB60-GB6Z]
P04637 P53_HUMAN Hearing disorder [ICD-11: AB50-AB57]
Q6ZQN7 SO4C1_HUMAN Cardiac arrhythmia [ICD-11: BC9Z]
Q6ZQN7 SO4C1_HUMAN Heart failure [ICD-11: BD10-BD1Z]
Q6ZQN7 SO4C1_HUMAN Cardiac arrhythmia [ICD-11: BC9Z]
Q6ZQN7 SO4C1_HUMAN Heart failure [ICD-11: BD10-BD1Z]