Basic Information

Terpenoid ID TKC206780
Cell line 0
Protein target 24
DiseaseNCIT 0
ORDO 0
ICD 64

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC206780 HepG2 15849.0 nM Potency C3728 Orphanet_449
TKC206780 Hepatocyte 6.0 pmol Drug excretion

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206780 P10636 Microtubule-associated protein tau MAPT 11220 nM Potency
TKC206780 P11473 Vitamin D3 receptor VDR 89125 nM Potency
TKC206780 Q16637 Survival motor neuron protein SMN1,SMN2 19953 nM Potency
TKC206780 Q16637 Survival motor neuron protein SMN1,SMN2 19953 nM Potency
TKC206780 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 299 nM Potency
TKC206780 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 56 % Inhibition
TKC206780 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 41 % Inhibition
TKC206780 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 18356 nM Potency
TKC206780 P43220 Glucagon-like peptide 1 receptor GLP1R 12589 nM Potency
TKC206780 P84022 Mothers against decapentaplegic homolog 3 SMAD3 8913 nM Potency
TKC206780 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 17783 nM Potency
TKC206780 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 20596 nM Potency
TKC206780 Q99700 Ataxin-2 ATXN2 31623 nM Potency
TKC206780 O75496 Geminin GMNN 7308 nM Potency
TKC206780 P37840 Alpha-synuclein SNCA 35481 nM Potency
TKC206780 P0DTD1 Replicase polyprotein 1ab rep 29 % Inhibition
TKC206780 P63096 Guanine nucleotide-binding protein G GNAI1 25119 nM Potency
TKC206780 Q6W5P4 Neuropeptide S receptor NPSR1 10000 nM Potency
TKC206780 O00255 Menin MEN1 11220 nM Potency
TKC206780 P02791 Ferritin light chain FTL 19953 nM Potency
TKC206780 Q9F4F7 4'-phosphopantetheinyl transferase ffp ffp 50119 nM Potency
TKC206780 Q16665 Hypoxia-inducible factor 1-alpha HIF1A 3981 nM Potency
TKC206780 Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B BAZ2B 79433 nM Potency
TKC206780 P51450 Nuclear receptor ROR-gamma Rorc 35481 nM Potency
TKC206780 P02545 Prelamin-A/C LMNA 19953 nM Potency
TKC206780 P42858 Huntingtin HTT 10000 nM Potency
TKC206780 P9WHJ3 Protein RecA recA 4880 nM EC50
TKC206780 P9WMR3 Replicative DNA helicase dnaB 2023 nM AC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P37840 SYUA_HUMAN Parkinsonism [ICD-11: 8A00]
P37840 SYUA_HUMAN Alzheimer disease [ICD-11: 8A20]
P37840 SYUA_HUMAN Autonomic nervous system disorder [ICD-11: 8D87]
Q16665 HIF1A_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q16665 HIF1A_HUMAN Brain cancer [ICD-11: 2A00]
Q16665 HIF1A_HUMAN Lymphoma [ICD-11: 2A80-2A86]
Q16665 HIF1A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q16665 HIF1A_HUMAN Pulmonary hypertension [ICD-11: BB01]
P42858 HD_HUMAN Choreiform disorder [ICD-11: 8A01]