Basic Information

Terpenoid ID TKC206758
Chirality TKC112756
Cell line 0
Protein target 33
DiseaseNCIT 0
ORDO 0
ICD 44

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206758 P11473 Vitamin D3 receptor VDR 56234 nM Potency
TKC206758 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 29093 nM Potency
TKC206758 P15207 Androgen receptor Ar 40738 nM IC50
TKC206758 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 21500 nM Km
TKC206758 P43220 Glucagon-like peptide 1 receptor GLP1R 12589 nM Potency
TKC206758 Q9UNA4 DNA polymerase iota POLI 89125 nM Potency
TKC206758 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 100000 nM Potency
TKC206758 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 35481 nM Potency
TKC206758 Q13148 TAR DNA-binding protein 43 TARDBP 17783 nM Potency
TKC206758 P0DTD1 Replicase polyprotein 1ab rep -1 % Inhibition
TKC206758 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 25 nM Potency
TKC206758 P63096 Guanine nucleotide-binding protein G GNAI1 11220 nM Potency
TKC206758 P54132 Bloom syndrome protein BLM 100000 nM Potency
TKC206758 Q01453 Peripheral myelin protein 22 PMP22 75686 nM Potency
TKC206758 Q92830 Histone acetyltransferase KAT2A KAT2A 8913 nM Potency
TKC206758 P02545 Prelamin-A/C LMNA 25119 nM Potency
TKC206758 O15439 ATP-binding cassette sub-family C member 4 ABCC4 3000 nM IC50
TKC206758 Q92887 ATP-binding cassette sub-family C member 2 ABCC2 395 % Activity
TKC206758 P22309 UDP-glucuronosyltransferase 1A1 UGT1A1 0 pm/min/mg Activity
TKC206758 P22310 UDP-glucuronosyltransferase 1A4 UGT1A4 28 pm/min/mg Activity
TKC206758 O60656 UDP-glucuronosyltransferase 1A9 UGT1A9 0 pm/min/mg Activity
TKC206758 P19224 UDP-glucuronosyltransferase 1-6 UGT1A6 0 pm/min/mg Activity
TKC206758 P54855 UDP-glucuronosyltransferase 2B15 UGT2B15 0 pm/min/mg Activity
TKC206758 Q9HAW8 UDP-glucuronosyltransferase 1A10 UGT1A10 0 pm/min/mg Activity
TKC206758 Q9HAW9 UDP-glucuronosyltransferase 1A8 UGT1A8 0 pm/min/mg Activity
TKC206758 Q9HAW7 UDP-glucuronosyltransferase 1A7 UGT1A7 0 pm/min/mg Activity
TKC206758 P16662 UDP-glucuronosyltransferase 2B7 UGT2B7 0 pm/min/mg Activity
TKC206758 O35627 Nuclear receptor subfamily 1 group I member 3 Nr1i3 54 % Remaining activity
TKC206758 P04278 Sex hormone-binding globulin SHBG 71 nM Kd
TKC206758 P08185 Corticosteroid-binding globulin SERPINA6 2455 nM Ki
TKC206758 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 10600 nM Ki
TKC206758 P46720 Solute carrier organic anion transporter family member 1A1 Slco1a1 5000 nM Km
TKC206758 P56937 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 HSD17B7 2 % Inhibition
TKC206758 Q9UNQ0 Broad substrate specificity ATP-binding cassette transporter ABCG2 ABCG2 50 % Activity
TKC206758 P0A6C1 Endonuclease 4 nfo 44668 nM Potency
TKC206758 O09028 Gamma-aminobutyric acid receptor subunit pi Gabrp 410 nM IC50
TKC206758 O35913 Solute carrier organic anion transporter family member 1A4 Slco1a4 17000 nM Km
TKC206758 O88397 Solute carrier organic anion transporter family member 1A5 Slco1a5 162000 nM Km
TKC206758 P46721 Solute carrier organic anion transporter family member 1A2 SLCO1A2 6600 nM Km
TKC206758 Q9QZX8 Solute carrier organic anion transporter family member 1B2 Slco1b2 5300 nM Km
TKC206758 Q8TDU6 G-protein coupled bile acid receptor 1 GPBAR1 6220 nM EC50
TKC206758 P33527 Multidrug resistance-associated protein 1 ABCC1 5000 nM Km
TKC206758 P11413 Glucose-6-phosphate 1-dehydrogenase G6PD >200000 nM IC50
TKC206758 P70502 Solute carrier organic anion transporter family member 1A3 Slco1a3 7600 nM Km
TKC206758 Q9QXZ6 Solute carrier organic anion transporter family member 1A1 Slco1a1 8200 nM Km
TKC206758 P06133 UDP-glucuronosyltransferase 2B4 UGT2B4 0 pm/min/mg Activity
TKC206758 O75795 UDP-glucuronosyltransferase 2B17 UGT2B17 5 pm/min/mg Activity
TKC206758 P36537 UDP-glucuronosyltransferase 2B10 UGT2B10 0 pm/min/mg Activity
TKC206758 P08842 Steryl-sulfatase STS 1700 nM Km
TKC206758 Q96J66 ATP-binding cassette sub-family C member 11 ABCC11 13000 nM Km
TKC206758 Q9NSA0 Solute carrier family 22 member 11 SLC22A11 630 nM Km
TKC206758 O54939 Testosterone 17-beta-dehydrogenase 3 Hsd17b3 90 nM IC50
TKC206758 Q06278 Aldehyde oxidase AOX1 >100000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P22309 UD11_HUMAN Inborn porphyrin/heme metabolism error [ICD-11: 5C58]
P08185 CBG_HUMAN Asthma [ICD-11: CA23]
P08185 CBG_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P08185 CBG_HUMAN Respiratory system disease [ICD-11: CB40-CB7Z]
P08185 CBG_HUMAN Retinopathy [ICD-11: 9B71]
Q9UNQ0 ABCG2_HUMAN Irritable bowel syndrome [ICD-11: DD91]
Q9UNQ0 ABCG2_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q8TDU6 GPBAR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
Q8TDU6 GPBAR_HUMAN Hepatic fibrosis/cirrhosis [ICD-11: DB93]
Q8TDU6 GPBAR_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P33527 MRP1_HUMAN Gout [ICD-11: FA25]
P11413 G6PD_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P11413 G6PD_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P11413 G6PD_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P08842 STS_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P08842 STS_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P08842 STS_HUMAN Endometriosis [ICD-11: GA10]
P08842 STS_HUMAN Low bone mass disorder [ICD-11: FB83]
P08842 STS_HUMAN Prostate cancer [ICD-11: 2C82]
Q06278 AOXA_HUMAN Prostate cancer [ICD-11: 2C82]
Q06278 AOXA_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q06278 AOXA_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]