Basic Information

Terpenoid ID TKC206690
Chirality TKC110010
Cell line 0
Protein target 21
DiseaseNCIT 0
ORDO 0
ICD 81

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC206690 SN12C SN-12C 100000.0 nM GI50 C9385 Orphanet_217071
TKC206690 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 100000.0 nM GI50 C3512
TKC206690 UO-31 UO.31; UO31; U031 100000.0 nM GI50 C9385 Orphanet_217071
TKC206690 ACHN 100000.0 nM GI50 C6975 Orphanet_319298
TKC206690 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 100000.0 nM GI50 C9154 Orphanet_519
TKC206690 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 100000.0 nM GI50 C2926
TKC206690 SF-539 SF-539; SF-539 BT; SF.539; SF 539 100000.0 nM GI50 C3796 Orphanet_251576
TKC206690 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 100000.0 nM GI50 C3510
TKC206690 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 100000.0 nM GI50 C3224
TKC206690 A498 A498 100000.0 nM GI50 C9385 Orphanet_217071
TKC206690 K562 K562; K.562; K 562; KO; GM05372; GM05372E 100000.0 nM GI50 C9110 Orphanet_521
TKC206690 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 100000.0 nM GI50 C105555
TKC206690 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 100000.0 nM GI50 C9142 Orphanet_99861
TKC206690 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 100000.0 nM GI50 C60781 Orphanet_94
TKC206690 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 100000.0 nM GI50 C105555
TKC206690 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 100000.0 nM GI50 C60781 Orphanet_94
TKC206690 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 100000.0 nM GI50 C4917 Orphanet_70573
TKC206690 SR SR-786; SR786 100000.0 nM GI50 C37193 Orphanet_300895
TKC206690 SW-620 SW-620; SW 620; SW.620 100000.0 nM GI50 C4349
TKC206690 M19-MEL M-19; M19 100000.0 nM GI50 C3802
TKC206690 TK-10 TK.10; TK 10; TK10 100000.0 nM GI50 C4033 Orphanet_319276
TKC206690 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 100000.0 nM GI50 C3512
TKC206690 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 100000.0 nM GI50 C3802
TKC206690 XF498 XF-498; XF498 100000.0 nM GI50 C3058 Orphanet_360
TKC206690 KM12 KM-12; KM.12 100000.0 nM GI50 C4910
TKC206690 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 100000.0 nM GI50 C3242 Orphanet_29073
TKC206690 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 100000.0 nM GI50 C2923
TKC206690 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 100000.0 nM GI50 C105555
TKC206690 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 100000.0 nM GI50 C3224
TKC206690 KM-20L2 KM-20L2; KM 20L2; KM 2012 100000.0 nM GI50 C4349
TKC206690 A549 100000.0 nM GI50 C3512
TKC206690 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 100000.0 nM GI50 C4349
TKC206690 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 100000.0 nM GI50 C3058 Orphanet_360
TKC206690 HCT-15 HCT-15; HCT.15; HCT15 100000.0 nM GI50 C4349
TKC206690 SF-268 SF-268; SF.268; SF 268 100000.0 nM GI50 C60781 Orphanet_94
TKC206690 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 100000.0 nM GI50 C4910
TKC206690 EKVX 100000.0 nM GI50 C3512
TKC206690 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 100000.0 nM GI50 C2926
TKC206690 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 100000.0 nM GI50 C4917 Orphanet_70573
TKC206690 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 100000.0 nM GI50 C7978
TKC206690 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 100000.0 nM GI50 C4450
TKC206690 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 100000.0 nM GI50 C3224
TKC206690 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 100000.0 nM GI50 C7979 Orphanet_454723
TKC206690 SF-295 SF-295; SF.295; SF 295 100000.0 nM GI50 C3058 Orphanet_360
TKC206690 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 100000.0 nM GI50 C9385 Orphanet_217071
TKC206690 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 100000.0 nM GI50 C7953 Orphanet_99861
TKC206690 DLD-1 DLD 1; DLD1; CoCL3 100000.0 nM GI50 C4349
TKC206690 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 100000.0 nM GI50 C45662 Orphanet_50251
TKC206690 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 100000.0 nM GI50 C3510
TKC206690 HT-29 HT 29; HT29 100000.0 nM GI50 C4349
TKC206690 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 100000.0 nM GI50 C4349
TKC206690 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 100000.0 nM GI50 C9385 Orphanet_217071
TKC206690 HOP-18 HOP 18; Hop 18; HOP18; Hop18; Hopkins-18 100000.0 nM GI50 C4450

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC206690 P00352 Retinal dehydrogenase 1 ALDH1A1 39811 nM Potency
TKC206690 Q16637 Survival motor neuron protein SMN1,SMN2 1259 nM Potency
TKC206690 Q16637 Survival motor neuron protein SMN1,SMN2 1259 nM Potency
TKC206690 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 33498 nM Potency
TKC206690 P08684 Cytochrome P450 3A4 CYP3A4 10000 nM Potency
TKC206690 P10275 Androgen receptor AR 36 nM Potency
TKC206690 O75496 Geminin GMNN 18356 nM Potency
TKC206690 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 891 nM Potency
TKC206690 P39748 Flap endonuclease 1 FEN1 2 nM Potency
TKC206690 Q13148 TAR DNA-binding protein 43 TARDBP 8913 nM Potency
TKC206690 P04150 Glucocorticoid receptor NR3C1 28184 nM Potency
TKC206690 P21728 D(1A) dopamine receptor DRD1 26 nM Potency
TKC206690 P83916 Chromobox protein homolog 1 CBX1 6 nM Potency
TKC206690 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 11220 nM Potency
TKC206690 Q01453 Peripheral myelin protein 22 PMP22 30131 nM Potency
TKC206690 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 7943 nM Potency
TKC206690 P49798 Regulator of G-protein signaling 4 RGS4 89125 nM Potency
TKC206690 P08482 Muscarinic acetylcholine receptor M1 Chrm1 12589 nM Potency
TKC206690 O95342 Bile salt export pump ABCB11 108100 nM IC50
TKC206690 Q9R1A7 Nuclear receptor subfamily 1 group I member 2 Nr1i2 35481 nM Potency
TKC206690 P0A6C1 Endonuclease 4 nfo 631 nM Potency
TKC206690 Q99549 M-phase phosphoprotein 8 MPHOSPH8 100000 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
P10275 ANDR_HUMAN Acne vulgaris [ICD-11: ED80]
P10275 ANDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10275 ANDR_HUMAN Alcoholic liver disease [ICD-11: DB94]
P10275 ANDR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P10275 ANDR_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P10275 ANDR_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P10275 ANDR_HUMAN Female pelvic pain [ICD-11: GA34]
P10275 ANDR_HUMAN Hypo-osmolality/hyponatraemia [ICD-11: 5C72]
P10275 ANDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P10275 ANDR_HUMAN Mammary tumour [ICD-11: 2C60-2C6Z]
P10275 ANDR_HUMAN Pituitary gland disorder [ICD-11: 5A60-5A61]
P10275 ANDR_HUMAN Prostate cancer [ICD-11: 2C82]
P10275 ANDR_HUMAN Testicular dysfunction [ICD-11: 5A81]
P10275 ANDR_HUMAN Prostate hyperplasia [ICD-11: GA90]
P10275 ANDR_HUMAN Alopecia [ICD-11: ED70]
P10275 ANDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P10275 ANDR_HUMAN Thrombosis [ICD-11: DB61-GB90]
P10275 ANDR_HUMAN Contraceptive management [ICD-11: QA21]
P10275 ANDR_HUMAN Heart failure [ICD-11: BD10-BD1Z]
P10275 ANDR_HUMAN Muscle disorder [ICD-11: FB32-FB3Z]
P10275 ANDR_HUMAN Muscular dystrophy [ICD-11: 8C70]
P10275 ANDR_HUMAN Cystic fibrosis [ICD-11: CA25]
P10275 ANDR_HUMAN Pain [ICD-11: MG30-MG3Z]
P10275 ANDR_HUMAN Cachexia [ICD-11: MG20]
P10275 ANDR_HUMAN Dissociative neurological symptom disorder [ICD-11: 6B60]
P10275 ANDR_HUMAN Bladder cancer [ICD-11: 2C94]
P10275 ANDR_HUMAN Oesophagitis [ICD-11: DA24]
P10275 ANDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P10275 ANDR_HUMAN Prostate hyperplasia [ICD-11: GA90]
P10275 ANDR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P10275 ANDR_HUMAN Prostate cancer [ICD-11: 2C82]
P10275 ANDR_HUMAN Acne vulgaris [ICD-11: ED80]
P10275 ANDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
P04150 GCR_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P04150 GCR_HUMAN Indeterminate colitis [ICD-11: DD72]
P04150 GCR_HUMAN Multiple sclerosis [ICD-11: 8A40]
P04150 GCR_HUMAN Muscular dystrophy [ICD-11: 8C70]
P04150 GCR_HUMAN Prostate cancer [ICD-11: 2C82]
P04150 GCR_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P04150 GCR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P04150 GCR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04150 GCR_HUMAN Adaptive immunity immunodeficiency [ICD-11: 4A01]
P04150 GCR_HUMAN Adrenogenital disorder [ICD-11: 5A71]
P04150 GCR_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P04150 GCR_HUMAN Asthma [ICD-11: CA23]
P04150 GCR_HUMAN Atopic eczema [ICD-11: EA80]
P04150 GCR_HUMAN Chronic obstructive pulmonary disease [ICD-11: CA22]
P04150 GCR_HUMAN Cushing syndrome [ICD-11: 5A70]
P04150 GCR_HUMAN Eczema [ICD-11: EA80-EA89]
P04150 GCR_HUMAN Multiple sclerosis [ICD-11: 8A40]
P04150 GCR_HUMAN Muscular dystrophy [ICD-11: 8C70]
P04150 GCR_HUMAN Oesophagitis [ICD-11: DA24]
P04150 GCR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P04150 GCR_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P04150 GCR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P04150 GCR_HUMAN Spine/trunk injury [ICD-11: ND51]
P04150 GCR_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
P04150 GCR_HUMAN Herpes simplex infection [ICD-11: 1F00]
P04150 GCR_HUMAN Otitis externa [ICD-11: AA00-AA13]
P04150 GCR_HUMAN Substance abuse [ICD-11: 6C40]
P04150 GCR_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P04150 GCR_HUMAN Depression [ICD-11: 6A70-6A7Z]
P04150 GCR_HUMAN Mood disorder [ICD-11: 6A60-6E23]
P04150 GCR_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P04150 GCR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P04150 GCR_HUMAN Retinopathy [ICD-11: 9B71]
P04150 GCR_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
P21728 DRD1_HUMAN Abortion [ICD-11: JA00]
P21728 DRD1_HUMAN Allergic/hypersensitivity disorder [ICD-11: 4A80-4A8Z]
P21728 DRD1_HUMAN Hypertension [ICD-11: BA00-BA04]
P21728 DRD1_HUMAN Parkinsonism [ICD-11: 8A00]
P21728 DRD1_HUMAN Cocaine use disorder [ICD-11: 6C45]
P21728 DRD1_HUMAN Schizophrenia [ICD-11: 6A20]
P21728 DRD1_HUMAN Tic disorder [ICD-11: 8A05]
P21728 DRD1_HUMAN Dementia [ICD-11: 6D80-6D8Z]
P21728 DRD1_HUMAN Psychotic disorder [ICD-11: 6A20-6A25]
P21728 DRD1_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P21728 DRD1_HUMAN Pain [ICD-11: MG30-MG3Z]
P21728 DRD1_HUMAN Glaucoma [ICD-11: 9C61]
P21728 DRD1_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
P21728 DRD1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P21728 DRD1_HUMAN Unspecific substance use disorder [ICD-11: 6C4Z]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]