Basic Information

Terpenoid ID TKC197340
Chirality TKC197338
Cell line 0
Protein target 9
DiseaseNCIT 0
ORDO 0
ICD 7

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC197340 HCT-8 HCT-8; HCT8 310.0 nM IC50 C4349
TKC197340 Bel-7402 Bel-7402; BEL 7402; Bel 7402; BEL7402; Bel7402 920.0 nM IC50 C27677
TKC197340 BGC-823 BGC823 100.0 nM IC50 C27677
TKC197340 A549 8.0 nM IC50 C3512
TKC197340 A2780 A-2780; 2780; A2780S; A2780par 13.0 nM IC50 C7979 Orphanet_454723
TKC197340 MCF7 4.0 nM IC50 C4194
TKC197340 P388 P-388 158.0 % T/C C21602
TKC197340 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 300.0 nM IC50 C7979 Orphanet_454723
TKC197340 SW480 SW-480; SW 480; SW480E 33.0 nM IC50 C4349
TKC197340 HepG2 20.0 nM IC50 C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC197340 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 10 nM Potency
TKC197340 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 7 nM Potency
TKC197340 Q99700 Ataxin-2 ATXN2 17783 nM Potency
TKC197340 O75496 Geminin GMNN 291 nM Potency
TKC197340 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 28184 nM Potency
TKC197340 P02791 Ferritin light chain FTL 31623 nM Potency
TKC197340 P51450 Nuclear receptor ROR-gamma Rorc 11220 nM Potency
TKC197340 Q194T2 Non-structural protein 1 NS1 14125 nM Potency
TKC197340 Q14974 Importin subunit beta-1 KPNB1 125893 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]