Basic Information

Terpenoid ID TKC174441
Cell line 0
Protein target 20
DiseaseNCIT 0
ORDO 0
ICD 55

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC174441 HepG2 35481.0 nM Potency C3728 Orphanet_449

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC174441 P11473 Vitamin D3 receptor VDR 89125 nM Potency
TKC174441 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 4611 nM Potency
TKC174441 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 16360 nM Potency
TKC174441 P43220 Glucagon-like peptide 1 receptor GLP1R 31623 nM Potency
TKC174441 P84022 Mothers against decapentaplegic homolog 3 SMAD3 35481 nM Potency
TKC174441 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 3548 nM Potency
TKC174441 Q77YF9 Protein Vpr vpr 22387 nM Potency
TKC174441 P27695 DNA-(apurinic or apyrimidinic site) endonuclease APEX1 8437 nM Potency
TKC174441 Q9UNA4 DNA polymerase iota POLI 89125 nM Potency
TKC174441 O75496 Geminin GMNN 25929 nM Potency
TKC174441 Q13148 TAR DNA-binding protein 43 TARDBP 12589 nM Potency
TKC174441 P83916 Chromobox protein homolog 1 CBX1 89125 nM Potency
TKC174441 O00255 Menin MEN1 44668 nM Potency
TKC174441 P02791 Ferritin light chain FTL 50119 nM Potency
TKC174441 Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B BAZ2B 708 nM Potency
TKC174441 P51450 Nuclear receptor ROR-gamma Rorc 11220 nM Potency
TKC174441 O75030 Microphthalmia-associated transcription factor MITF 10980 nM AC50
TKC174441 Q194T2 Non-structural protein 1 NS1 1413 nM Potency
TKC174441 Q13315 Serine-protein kinase ATM ATM 412 nM Potency
TKC174441 P80244 ATP-dependent Clp protease proteolytic subunit clpP 28184 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P27695 APEX1_HUMAN Retinopathy [ICD-11: 9B71]
P27695 APEX1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P27695 APEX1_HUMAN Ocular cancer [ICD-11: 2D00-2D07]
P27695 APEX1_HUMAN Brain cancer [ICD-11: 2A00]
P27695 APEX1_HUMAN Melanoma [ICD-11: 2C30]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
Q13315 ATM_HUMAN Brain cancer [ICD-11: 2A00]
Q13315 ATM_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13315 ATM_HUMAN Lung cancer [ICD-11: 2C25]