Basic Information

Terpenoid ID TKC152772
Chirality TKC149004
Cell line 0
Protein target 2
DiseaseNCIT 0
ORDO 0
ICD 11

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC152772 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 18.0 ug ml-1 ED50 C3224
TKC152772 HOP-92 HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 36141.0 nM GI50 C2926
TKC152772 B16 B-16; B16 melanoma; B16 subline B78; B78 38000.0 nM IC50 C21790
TKC152772 HepG2 20.0 ug.mL-1 IC50 C3728 Orphanet_449
TKC152772 PANC-1 Panc-1; PANC.1; Panc 1; PanC1; Panc1; PANC1; Panc-1-P 39.0 uM PC50 C9120
TKC152772 Ca9-22 CA9-22; Ca 9-22; CA922; Ca922 17.0 ug.mL-1 IC50 C129857 Orphanet_502363
TKC152772 MDA-N MDAN 32659.0 nM GI50 C3802
TKC152772 SN12C SN-12C 36475.0 nM GI50 C9385 Orphanet_217071
TKC152772 ACHN 55081.0 nM GI50 C6975 Orphanet_319298
TKC152772 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 61518.0 nM GI50 C3512
TKC152772 UO-31 UO.31; UO31; U031 47753.0 nM GI50 C9385 Orphanet_217071
TKC152772 SF-539 SF-539; SF-539 BT; SF.539; SF 539 88716.0 nM GI50 C3796 Orphanet_251576
TKC152772 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 100000.0 nM GI50 C4863
TKC152772 Malme-3M MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer 89331.0 nM GI50 C3224
TKC152772 SK-MEL-5 SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel 73961.0 nM GI50 C3510
TKC152772 A498 A498 13366.0 nM GI50 C9385 Orphanet_217071
TKC152772 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 55081.0 nM GI50 C105555
TKC152772 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 27542.0 nM GI50 C9142 Orphanet_99861
TKC152772 HOP-62 HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 58345.0 nM GI50 C3512
TKC152772 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 26730.0 nM GI50 C105555
TKC152772 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 21878.0 nM GI50 C60781 Orphanet_94
TKC152772 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 33266.0 nM GI50 C105555
TKC152772 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 100000.0 nM GI50 C105555
TKC152772 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 100000.0 nM GI50 C4917 Orphanet_70573
TKC152772 SNB-19 SNB.19; SNB19; Surgical Neurology Branch-19 47315.0 nM GI50 C60781 Orphanet_94
TKC152772 TK-10 TK.10; TK 10; TK10 79616.0 nM GI50 C4033 Orphanet_319276
TKC152772 SR SR-786; SR786 42756.0 nM GI50 C37193 Orphanet_300895
TKC152772 M19-MEL M-19; M19 100000.0 nM GI50 C3802
TKC152772 SW-620 SW-620; SW 620; SW.620 48195.0 nM GI50 C4349
TKC152772 KM12 KM-12; KM.12 66988.0 nM GI50 C4910
TKC152772 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 23768.0 nM GI50 C3512
TKC152772 M14 M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 94624.0 nM GI50 C3802
TKC152772 XF498 XF-498; XF498 100000.0 nM GI50 C3058 Orphanet_360
TKC152772 RPMI-8226 RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson 53703.0 nM GI50 C3242 Orphanet_29073
TKC152772 NCI-H322M NCI.H322M; H322M; H-322M; H-322m 100000.0 nM GI50 C2923
TKC152772 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 100000.0 nM GI50 C105555
TKC152772 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 19454.0 nM GI50 C3802
TKC152772 KM-20L2 KM-20L2; KM 20L2; KM 2012 100000.0 nM GI50 C4349
TKC152772 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 100000.0 nM GI50 C4349
TKC152772 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 38194.0 nM GI50 C3058 Orphanet_360
TKC152772 HCT-15 HCT-15; HCT.15; HCT15 70146.0 nM GI50 C4349
TKC152772 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 44463.0 nM GI50 C4910
TKC152772 SF-268 SF-268; SF.268; SF 268 55719.0 nM GI50 C60781 Orphanet_94
TKC152772 EKVX 72946.0 nM GI50 C3512
TKC152772 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 65766.0 nM GI50 C4917 Orphanet_70573
TKC152772 LXFL 529 LXFL-529L; LXFL529L; LXF 529 L; LXFL-529; LXFL 529; LXFL529; LXF 529 100000.0 nM GI50 C2926
TKC152772 T47D 100000.0 nM GI50 C4194
TKC152772 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 45709.0 nM GI50 C4450
TKC152772 UACC-62 UACC 62; UACC.62; UACC62; University of Arizona Cell Culture-62 100000.0 nM GI50 C3224
TKC152772 MDA-MB-435 MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 19364.0 nM GI50 C3802
TKC152772 CAKI-1 CAL 1; Centre Antoine Lacassagne-1 81096.0 nM GI50 C3224
TKC152772 SF-295 SF-295; SF.295; SF 295 50816.0 nM GI50 C3058 Orphanet_360
TKC152772 IGROV-1 Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P 54702.0 nM GI50 C7979 Orphanet_454723
TKC152772 Hs-578T HS 578T; Hs-578T; HS-578T; Hs_578t; Hs-578-T; HS-578-T; Hs 578.T; HS578T; Hs578T; Hs578t; HS0578T; 578T; HS578; Hs578; Homo sapiens No. 578, tumor cells 25645.0 nM GI50 C4194
TKC152772 786-0 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT 37239.0 nM GI50 C9385 Orphanet_217071
TKC152772 UACC-257 UACC 257; UACC.257; UACC257; University of Arizona Cell Culture-257 42658.0 nM GI50 C3224
TKC152772 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 22131.0 nM GI50 C7953 Orphanet_99861
TKC152772 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 50350.0 nM GI50 C45662 Orphanet_50251
TKC152772 HT-29 HT 29; HT29 78163.0 nM GI50 C4349
TKC152772 SK-MEL-28 SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 65163.0 nM GI50 C3510
TKC152772 RXF 393 RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL 13964.0 nM GI50 C9385 Orphanet_217071
TKC152772 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 25180.0 nM IC50 C4349
TKC152772 L6 L-6; L-6 myoblast 27.0 % Activity
TKC152772 LLC-PK1 LLC-PK(1); LLC-PK-1; LLC PK-1; LLc-PK1; LLC PK1; LLCPK1; Lilly Laboratories Culture-Porcine Kidney 1 80.0 % Activity
TKC152772 BHY 25180.0 nM IC50 C34447
TKC152772 MIA PaCa-2 MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2; MiaPaCa 25180.0 nM IC50 C9120

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC152772 P18031 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 3680 nM IC50
TKC152772 P47199 Quinone oxidoreductase Cryz >10 ug ml-1 CD
TKC152772 P11388 DNA topoisomerase 2-alpha TOP2A 10400 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P18031 PTN1_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P18031 PTN1_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P18031 PTN1_HUMAN Obesity [ICD-11: 5B80-5B81]
P18031 PTN1_HUMAN Ophthalmic devices/implants/grafts injury [ICD-11: PK97]
P18031 PTN1_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P18031 PTN1_HUMAN Metabolic disorder [ICD-11: 5C50-5D2Z]
P18031 PTN1_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P11388 TOP2A_HUMAN Kaposi sarcoma [ICD-11: 2B57]
P11388 TOP2A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11388 TOP2A_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11388 TOP2A_HUMAN Mature T-cell lymphoma [ICD-11: 2A90]