Basic Information

Terpenoid ID TKC146761
Cell line 45
Protein target 5
DiseaseNCIT 46
ORDO 16
ICD 10

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC146761 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 18700 nM IC50 C9154 Orphanet_519
TKC146761 Jurkat JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024 650 nM IC50 C7953 Orphanet_99861
TKC146761 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 19055 nM GI50 C5214
TKC146761 A549 None 630 nM IC50 C3512
TKC146761 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 850 nM IC50 C7978
TKC146761 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 750 nM IC50 C3224
TKC146761 XF498 XF-498; XF498 540 nM IC50 C3058 Orphanet_360
TKC146761 HCT-15 HCT-15; HCT.15; HCT15 460 nM IC50 C4349
TKC146761 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 8850 nM IC50 C27677
TKC146761 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 3311 nM GI50 C60781 Orphanet_94
TKC146761 SF-295 SF-295; SF.295; SF 295 15488 nM GI50 C3058 Orphanet_360
TKC146761 SF-539 SF-539; SF-539 BT; SF.539; SF 539 9772 nM GI50 C3796 Orphanet_251576
TKC146761 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 11749 nM GI50 C3058 Orphanet_360
TKC146761 SNB-78 SNB78; Surgical Neurology Branch-78 8318 nM GI50 C3058 Orphanet_360
TKC146761 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 14791 nM GI50 C4349
TKC146761 KM12 KM-12; KM.12 6026 nM GI50 C4910
TKC146761 HT-29 HT 29; HT29 4365 nM GI50 C4349
TKC146761 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 6166 nM GI50 C3512
TKC146761 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 15849 nM GI50 C45662 Orphanet_50251
TKC146761 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 2291 nM GI50 C3512
TKC146761 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 7413 nM GI50 C4450
TKC146761 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 4467 nM GI50 C4917 Orphanet_70573
TKC146761 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 1585 nM GI50 C4917 Orphanet_70573
TKC146761 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 3162 nM GI50 C3802
TKC146761 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 10233 nM GI50 C105555
TKC146761 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 12883 nM GI50 C105555
TKC146761 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 12883 nM GI50 C105555
TKC146761 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 4169 nM GI50 C105555
TKC146761 ACHN None 7079 nM GI50 C6975 Orphanet_319298
TKC146761 St-4 None 5370 nM GI50 C4911
TKC146761 MKN-7 MKN-7; MKN 7 3020 nM GI50 C5473
TKC146761 MKN-28 MKN-28; MKN 28 4571 nM GI50 C5473
TKC146761 MKN-45 MKN-45; MKN 45 5248 nM GI50 C4004
TKC146761 MKN-74 MKN-74; MKN 74 3981 nM GI50 C5473
TKC146761 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 18621 nM GI50 C4863
TKC146761 PC-3 PC3; PC.3 3162 nM GI50 C4863
TKC146761 K562 K562; K.562; K 562; KO; GM05372; GM05372E 9810 nM IC50 C9110 Orphanet_521
TKC146761 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 90 nM IC50 C7953 Orphanet_99861
TKC146761 SMMC-7721 SMMC 7721; SMMC7721; H7721; H-7721 13800 nM IC50 C27677
TKC146761 HEK293 None 9900 nM IC50
TKC146761 J774 J-774 1500 nM EC50 C134780
TKC146761 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 5640 nM IC50 C5214
TKC146761 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 85 nM EC50 C7953 Orphanet_99861
TKC146761 ADR5000 cell line CCRF ADR5000; CCRF-ADR5000; CEM/ADR5000; CEM/ADR 5000; CEM-ADR5000; CEM ADR5000; ADR5000 265 nM EC50 C7953 Orphanet_99861
TKC146761 HT-29 HT 29; HT29 18520 nM IC50 C4349
TKC146761 U-937 U937; U 937 910 nM GI50 C8263 Orphanet_514
TKC146761 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 3320 nM GI50 C105555

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC146761 P08684 Cytochrome P450 3A4 CYP3A4 125000 nM IC50
TKC146761 P08183 ATP-dependent translocase ABCB1 ABCB1 25 10'-6 cm/s Papp
TKC146761 P0DTD1 Replicase polyprotein 1ab rep 6 % Inhibition
TKC146761 P11712 Cytochrome P450 2C9 CYP2C9 1 FC
TKC146761 P20813 Cytochrome P450 2B6 CYP2B6 125000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11 Disease
P08684 CP3A4_HUMAN ICD-11: 2A00-2F9Z tumour/cancer
P08684 CP3A4_HUMAN ICD-11: EA80 eczema
P08684 CP3A4_HUMAN ICD-11: 6B00-6B0Z disorder
P08183 MDR1_HUMAN ICD-11: 2C25 cancer
P08183 MDR1_HUMAN ICD-11: 2A00-2F9Z tumour/cancer
P08183 MDR1_HUMAN ICD-11: 1A00-1C4Z infection
P08183 MDR1_HUMAN ICD-11: 2A60 leukaemia
P08183 MDR1_HUMAN ICD-11: 2D11 cancer
P08183 MDR1_HUMAN ICD-11: 2C73 cancer
P11712 CP2C9_HUMAN ICD-11: 1A00-1C4Z infection