Basic Information

Terpenoid ID TKC146761
Chirality TKC146725
Cell line 0
Protein target 2
DiseaseNCIT 0
ORDO 0
ICD 3

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC146761 HUVEC HUV-EC-C; HUVEC 8910.0 nM IC50
TKC146761 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 18700.0 nM IC50 C9154 Orphanet_519
TKC146761 Jurkat JURKAT; JM; JM-Jurkat; Jurkat-FHCRC; Jurkat FHCRC; FHCRC-11; FHCRC subclone 11; FCCH1024 650.0 nM IC50 C7953 Orphanet_99861
TKC146761 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 19055.0 nM GI50 C5214
TKC146761 MCF7 50180.0 nM IC50 C4194
TKC146761 P388 P-388 2.0 uM Activity C21602
TKC146761 A549 630.0 nM IC50 C3512
TKC146761 SK-OV-3 SKOV-3; SK-OV3; SK.OV.3; SKOV3; Skov3; SKO3 850.0 nM IC50 C7978
TKC146761 SK-MEL-2 SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 750.0 nM IC50 C3224
TKC146761 XF498 XF-498; XF498 540.0 nM IC50 C3058 Orphanet_360
TKC146761 HCT-15 HCT-15; HCT.15; HCT15 460.0 nM IC50 C4349
TKC146761 Huh-7 HuH-7; HUH-7; HuH7; Huh7; HUH7; HUH7.0; JTC-39; Japanese Tissue Culture-39 44940.0 nM CC50 C7956 Orphanet_210159
TKC146761 CHO Chinese Hamster Ovary; CHO-ori 147700.0 nM IC50
TKC146761 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 8850.0 nM IC50 C27677
TKC146761 U-251 U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) 3311.0 nM GI50 C60781 Orphanet_94
TKC146761 SF-268 SF-268; SF.268; SF 268 20893.0 nM GI50 C60781 Orphanet_94
TKC146761 SF-295 SF-295; SF.295; SF 295 15488.0 nM GI50 C3058 Orphanet_360
TKC146761 SF-539 SF-539; SF-539 BT; SF.539; SF 539 9772.0 nM GI50 C3796 Orphanet_251576
TKC146761 SNB-75 SNB.75; SNB75; Surgical Neurology Branch-75 11749.0 nM GI50 C3058 Orphanet_360
TKC146761 SNB-78 SNB78; Surgical Neurology Branch-78 8318.0 nM GI50 C3058 Orphanet_360
TKC146761 HCC 2998 HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 14791.0 nM GI50 C4349
TKC146761 KM12 KM-12; KM.12 6026.0 nM GI50 C4910
TKC146761 HT-29 HT 29; HT29 4365.0 nM GI50 C4349
TKC146761 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 95410.0 nM IC50 C4910
TKC146761 NCI-H23 NCI.H23; NCI H23; H-23; H23; NCIH23 6166.0 nM GI50 C3512
TKC146761 NCI-H226 NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 15849.0 nM GI50 C45662 Orphanet_50251
TKC146761 NCI-H522 NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 2291.0 nM GI50 C3512
TKC146761 NCI-H460 NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 7413.0 nM GI50 C4450
TKC146761 DMS-273 DMS-273; DMS273; Darmouth Medical School 273 4467.0 nM GI50 C4917 Orphanet_70573
TKC146761 DMS-114 DMS-114; DMS114; Darmouth Medical School 114 1585.0 nM GI50 C4917 Orphanet_70573
TKC146761 LOX IMVI LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX 3162.0 nM GI50 C3802
TKC146761 OVCAR-3 Ovcar-3; OVCAR 3; OVCAR.3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR3; Ovcar3 10233.0 nM GI50 C105555
TKC146761 OVCAR-4 OVCAR 4; NIH:OVCAR-4; NIH:OVCAR4; OVCAR.4; OVCAR4; Ovcar4 12883.0 nM GI50 C105555
TKC146761 OVCAR-5 OVCAR 5; NIH:OVCAR-5; OVCAR.5; OVCAR5; Ovcar5; OVCA5 12883.0 nM GI50 C105555
TKC146761 OVCAR-8 OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 4169.0 nM GI50 C105555
TKC146761 ACHN 7079.0 nM GI50 C6975 Orphanet_319298
TKC146761 St-4 5370.0 nM GI50 C4911
TKC146761 MKN-7 MKN-7; MKN 7 3020.0 nM GI50 C5473
TKC146761 MKN-28 MKN-28; MKN 28 4571.0 nM GI50 C5473
TKC146761 MKN-45 MKN-45; MKN 45 5248.0 nM GI50 C4004
TKC146761 MKN-74 MKN-74; MKN 74 3981.0 nM GI50 C5473
TKC146761 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 18621.0 nM GI50 C4863
TKC146761 PC-3 PC3; PC.3 3162.0 nM GI50 C4863
TKC146761 Caco-2 CaCo-2; CACO-2; Caco 2; CACO 2; CACO2; CaCo2; CaCO2; Caco2; Caco-2/ATCC; Caco-II 26870.0 nM IC50 C4349
TKC146761 HT-1080 Ht-1080; HT 1080; HT1080; HT 1080.T 49140.0 nM IC50 C3043 Orphanet_2030
TKC146761 HepG2 30130.0 nM IC50 C3728 Orphanet_449
TKC146761 K562 K562; K.562; K 562; KO; GM05372; GM05372E 9810.0 nM IC50 C9110 Orphanet_521
TKC146761 SK-HEP1 SK-Hep-1; SK HEP-1; SK HEP 01; SK-Hep1; Sk-Hep1; SK Hep1; SKHEP-1; SKHEP1; SKHep1; SK_HEP1 30000.0 nM IC50 C7106
TKC146761 L6 L-6; L-6 myoblast 730.0 nM IC50
TKC146761 Hepatocyte 8.0 % Activity
TKC146761 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 90.0 nM IC50 C7953 Orphanet_99861
TKC146761 SMMC-7721 SMMC 7721; SMMC7721; H7721; H-7721 13800.0 nM IC50 C27677
TKC146761 A549 29900.0 nM IC50 C3512
TKC146761 MCF7 39900.0 nM IC50 C4194
TKC146761 MDCK MDCK (NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney 25.0 10'-6 cm/s Papp
TKC146761 HEK293 9900.0 nM IC50
TKC146761 HepG2 63700.0 nM IC50 C3728 Orphanet_449
TKC146761 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 39900.0 nM IC50 C9154 Orphanet_519
TKC146761 HUVEC HUV-EC-C; HUVEC 1400.0 nM IC50
TKC146761 J774 J-774 1500.0 nM EC50 C134780
TKC146761 MDA-MB-231 MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA-231P; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231 5640.0 nM IC50 C5214
TKC146761 A-375 A 375; A375; A375-MEL; A375-mel; A375mel 38500.0 nM IC50 C3802
TKC146761 L02 L02; LO2; HL-7702; HL7702; Liver-02; Human Liver-7702 34000.0 nM IC50 C27677
TKC146761 CCRF-CEM CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C 85.0 nM EC50 C7953 Orphanet_99861
TKC146761 ADR5000 cell line CCRF ADR5000; CCRF-ADR5000; CEM/ADR5000; CEM/ADR 5000; CEM-ADR5000; CEM ADR5000; ADR5000 265.0 nM EC50 C7953 Orphanet_99861
TKC146761 HT-29 HT 29; HT29 18520.0 nM IC50 C4349
TKC146761 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 32800.0 nM IC50 C4910
TKC146761 U-937 U937; U 937 910.0 nM GI50 C8263 Orphanet_514
TKC146761 NB-4 151.0 nM GI50
TKC146761 NCI/ADR-RES NCI/ADR-RES; NCI.ADR.RES; NCIADR.RES; NCI/ADRRES; NCIADRRES; ADR-RES; MCF-7/ADR; MCF-7/ADR-RES; MCF-7/AdrR; MCF-7/Adr; MCF-7/adr; MCF-7ADR; MCF7-ADR; MCF7ADR; OVCAR-8/ADR; OVCAR8/ADR 3320.0 nM GI50 C105555
TKC146761 Lu1 Lu1 39900.0 nM IC50 C21678
TKC146761 P388 P-388 39900.0 nM IC50 C21602
TKC146761 A-431 A431; A431/P 42440.0 nM IC50 C4819
TKC146761 COLO 205 Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 42440.0 nM IC50 C4349
TKC146761 KB KB (HeLa derivative); HeLa-KB; Strain KB 95300.0 nM IC50 C27677
TKC146761 PC-14 PC 14; PC14 45.0 % Activity C3512
TKC146761 C6 C-6; C 6; RGC-6; RGC6; RGc6 66.0 % Activity C64069

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC146761 P08684 Cytochrome P450 3A4 CYP3A4 125000 nM IC50
TKC146761 P08183 ATP-dependent translocase ABCB1 ABCB1 25 10'-6 cm/s Papp
TKC146761 P0DTD1 Replicase polyprotein 1ab rep 6 % Inhibition
TKC146761 P20813 Cytochrome P450 2B6 CYP2B6 125000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P08684 CP3A4_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08684 CP3A4_HUMAN Atopic eczema [ICD-11: EA80]
P08684 CP3A4_HUMAN Anxiety disorder [ICD-11: 6B00-6B0Z]
P08183 MDR1_HUMAN Lung cancer [ICD-11: 2C25]
P08183 MDR1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P08183 MDR1_HUMAN Bacterial infection [ICD-11: 1A00-1C4Z]
P08183 MDR1_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P08183 MDR1_HUMAN Adrenal cancer [ICD-11: 2D11]
P08183 MDR1_HUMAN Ovarian cancer [ICD-11: 2C73]