Basic Information

Terpenoid ID TKC143885
Cell line 0
Protein target 25
DiseaseNCIT 0
ORDO 0
ICD 77

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC143885 HepG2 3548.0 nM Potency C3728 Orphanet_449
TKC143885 Vero VERO; VeroCCL81; Vero 81; Vero-81; Verda reno 36820.0 nM CC50

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC143885 P11473 Vitamin D3 receptor VDR 79433 nM Potency
TKC143885 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 18356 nM Potency
TKC143885 P07900 Heat shock protein HSP 90-alpha HSP90AA1 649 nM AC50
TKC143885 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 18356 nM Potency
TKC143885 O95398 Rap guanine nucleotide exchange factor 3 RAPGEF3 50119 nM Potency
TKC143885 P43220 Glucagon-like peptide 1 receptor GLP1R 28184 nM Potency
TKC143885 P84022 Mothers against decapentaplegic homolog 3 SMAD3 3162 nM Potency
TKC143885 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 20596 nM Potency
TKC143885 Q77YF9 Protein Vpr vpr 5623 nM Potency
TKC143885 Q99700 Ataxin-2 ATXN2 11220 nM Potency
TKC143885 Q9UBT6 DNA polymerase kappa POLK 42284 nM Potency
TKC143885 Q9UNA4 DNA polymerase iota POLI 17783 nM Potency
TKC143885 O75496 Geminin GMNN 3663 nM Potency
TKC143885 P37840 Alpha-synuclein SNCA 22387 nM Potency
TKC143885 Q13148 TAR DNA-binding protein 43 TARDBP 35481 nM Potency
TKC143885 P83916 Chromobox protein homolog 1 CBX1 56234 nM Potency
TKC143885 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 29081 nM Potency
TKC143885 P63096 Guanine nucleotide-binding protein G GNAI1 44668 nM Potency
TKC143885 P29990 Genome polyprotein 30960 nM IC50
TKC143885 Q9Y253 DNA polymerase eta POLH 50119 nM Potency
TKC143885 P05412 Transcription factor AP-1 JUN 30000 nM IC50
TKC143885 P05412 Transcription factor AP-1 JUN 130000 nM IC50
TKC143885 Q99814 Endothelial PAS domain-containing protein 1 EPAS1 14400 nM IC50
TKC143885 O15648 ATP-dependent 6-phosphofructokinase pfk 37933 nM Potency
TKC143885 Q8IL32 Heat shock protein 90, putative PF3D7_1443900 1057 nM AC50
TKC143885 P01106 Myc proto-oncogene protein MYC 4000000 nM IC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P11473 VDR_HUMAN Chronic kidney disease [ICD-11: GB61]
P11473 VDR_HUMAN Hair/hair growth developmental defect [ICD-11: LC30]
P11473 VDR_HUMAN Hyper-parathyroidism [ICD-11: 5A51]
P11473 VDR_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
P11473 VDR_HUMAN Mineral deficiency [ICD-11: 5B5K]
P11473 VDR_HUMAN Psoriasis [ICD-11: EA90]
P11473 VDR_HUMAN Vitamin deficiency [ICD-11: 5B55-5B5F]
P11473 VDR_HUMAN Low bone mass disorder [ICD-11: FB83]
P11473 VDR_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P11473 VDR_HUMAN Prostate cancer [ICD-11: 2C82]
P11473 VDR_HUMAN Prostate disease [ICD-11: GA91]
P11473 VDR_HUMAN Abnormal micturition [ICD-11: MF50]
P11473 VDR_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P11473 VDR_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P11473 VDR_HUMAN Acne vulgaris [ICD-11: ED80]
P07900 HS90A_HUMAN Acute upper respiratory infection [ICD-11: CA07]
P07900 HS90A_HUMAN Asthma [ICD-11: CA23]
P07900 HS90A_HUMAN Vasomotor/allergic rhinitis [ICD-11: CA08]
P07900 HS90A_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
P07900 HS90A_HUMAN Multiple myeloma [ICD-11: 2A83]
P07900 HS90A_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P07900 HS90A_HUMAN Lung cancer [ICD-11: 2C25]
P07900 HS90A_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P07900 HS90A_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P07900 HS90A_HUMAN Stomach cancer [ICD-11: 2B72]
P07900 HS90A_HUMAN Alzheimer disease [ICD-11: 8A20]
P07900 HS90A_HUMAN Encephalopathy [ICD-11: 8E47]
P07900 HS90A_HUMAN Mature B-cell lymphoma [ICD-11: 2A85]
P07900 HS90A_HUMAN Melanoma [ICD-11: 2C30]
P07900 HS90A_HUMAN Neuropathy [ICD-11: 8C0Z]
P07900 HS90A_HUMAN Ovarian cancer [ICD-11: 2C73]
P07900 HS90A_HUMAN Diabetes mellitus [ICD-11: 5A10]
P07900 HS90A_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P07900 HS90A_HUMAN Unspecific body region injury [ICD-11: ND56]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O95398 RPGF3_HUMAN Epidermal dysplasias [ICD-11: EK90]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
P37840 SYUA_HUMAN Parkinsonism [ICD-11: 8A00]
P37840 SYUA_HUMAN Alzheimer disease [ICD-11: 8A20]
P37840 SYUA_HUMAN Autonomic nervous system disorder [ICD-11: 8D87]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
P05412 JUN_HUMAN Rheumatoid arthritis [ICD-11: FA20]
P05412 JUN_HUMAN Rheumatoid arthritis [ICD-11: FA20]
Q99814 EPAS1_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q99814 EPAS1_HUMAN Renal cell carcinoma [ICD-11: 2C90]
Q99814 EPAS1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q99814 EPAS1_HUMAN Brain cancer [ICD-11: 2A00]
Q99814 EPAS1_HUMAN Adrenomedullary hyperfunction [ICD-11: 5A75]
Q99814 EPAS1_HUMAN Brain cancer [ICD-11: 2A00]
Q99814 EPAS1_HUMAN Renal cell carcinoma [ICD-11: 2C90]
P01106 MYC_HUMAN Coronary atherosclerosis [ICD-11: BA80]
P01106 MYC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]