Basic Information

Terpenoid ID TKC140412
Chirality TKC102540
Cell line 0
Protein target 14
DiseaseNCIT 0
ORDO 0
ICD 14

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC140412 L6 L-6; L-6 myoblast 13.0 ug.mL-1 IC50
TKC140412 KB KB (HeLa derivative); HeLa-KB; Strain KB 39.0 % Activity C27677
TKC140412 P388 P-388 5.0 ug.mL-1 IC50 C21602
TKC140412 MCF7 28960.0 nM IC50 C4194
TKC140412 SK-BR-3 SK-Br-3; Sk-Br-3; SK BR 03; SKBR-3; SKBr-3; SK-BR3; SKBr3; SkBr3; SKBR3 12000.0 nM IC50 C5214
TKC140412 HepG2 10260.0 nM IC50 C3728 Orphanet_449
TKC140412 HEK293 20596.0 nM Potency

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC140412 P10636 Microtubule-associated protein tau MAPT 14125 nM Potency
TKC140412 Q16637 Survival motor neuron protein SMN1,SMN2 35481 nM Potency
TKC140412 Q16637 Survival motor neuron protein SMN1,SMN2 35481 nM Potency
TKC140412 Q9NPD5 Solute carrier organic anion transporter family member 1B3 SLCO1B3 61 % Inhibition
TKC140412 Q9Y6L6 Solute carrier organic anion transporter family member 1B1 SLCO1B1 74 % Inhibition
TKC140412 Q77YF9 Protein Vpr vpr 63096 nM Potency
TKC140412 O75496 Geminin GMNN 23109 nM Potency
TKC140412 O89049 Thioredoxin reductase 1, cytoplasmic Txnrd1 39811 nM Potency
TKC140412 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 3981 nM Potency
TKC140412 Q13148 TAR DNA-binding protein 43 TARDBP 14125 nM Potency
TKC140412 P83916 Chromobox protein homolog 1 CBX1 100000 nM Potency
TKC140412 P00811 Beta-lactamase ampC 316 nM Potency
TKC140412 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 EHMT2 89125 nM Potency
TKC140412 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 25929 nM Potency
TKC140412 Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B BAZ2B 79433 nM Potency
TKC140412 P02545 Prelamin-A/C LMNA 17783 nM Potency
TKC140412 Q194T2 Non-structural protein 1 NS1 11220 nM Potency

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
Q16637 SMN_HUMAN Muscular atrophy [ICD-11: 8B61]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q13148 TADBP_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q13148 TADBP_HUMAN Alzheimer disease [ICD-11: 8A20]
Q96KQ7 EHMT2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q96KQ7 EHMT2_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
Q96KQ7 EHMT2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]