Basic Information
| Terpenoid ID | TKC135974 |
|
| Cell line | 0 | |
| Protein target | 1 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 32 |
| Terpenoid ID | TKC135974 |
|
| Cell line | 0 | |
| Protein target | 1 | |
| DiseaseNCIT | 0 | |
| ORDO | 0 | |
| ICD | 32 |
| ID | Cell Line | Synonyms | Value | Unit | Type | NCIt | ORDO |
|---|---|---|---|---|---|---|---|
| TKC135974 | HL-60 | HL 60; HL.60 HL60; Human Leukemia-60 | 209000.0 | nM | IC50 | C9154 | Orphanet_519 |
| TKC135974 | HT-29 | HT 29; HT29 | 8.0 | ug.mL-1 | IC50 | C4349 | |
| TKC135974 | MDA-MB-468 | MDA-MB 468; MDA-MB468; MDAMB468; MDA-468; MDA468; MB468; MD Anderson-Metastatic Breast-468 | 96.0 | % | Activity | C5214 | |
| TKC135974 | T47D | 111.0 | % | Activity | C4194 | ||
| TKC135974 | BT-549 | BT 549; BT.549; BT549 | 114.0 | % | Activity | C4194 | |
| TKC135974 | MCF7 | 20000.0 | nM | IC50 | C4194 | ||
| TKC135974 | TK-10 | TK.10; TK 10; TK10 | 110.0 | % | Activity | C4033 | Orphanet_319276 |
| TKC135974 | SN12C | SN-12C | 105.0 | % | Activity | C9385 | Orphanet_217071 |
| TKC135974 | RXF 393 | RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL | 103.0 | % | Activity | C9385 | Orphanet_217071 |
| TKC135974 | CAKI-1 | CAL 1; Centre Antoine Lacassagne-1 | 107.0 | % | Activity | C3224 | |
| TKC135974 | ACHN | 109.0 | % | Activity | C6975 | Orphanet_319298 | |
| TKC135974 | A498 | A498 | 88.0 | % | Activity | C9385 | Orphanet_217071 |
| TKC135974 | 786-0 | 786-o; 786O; 786-0; 786.O; 786-O RCC; RCC 786-O; RCC_7860; RCC 7860; 7860; 786-0WT | 80.0 | % | Activity | C9385 | Orphanet_217071 |
| TKC135974 | IGROV-1 | Igrov-1; IGROV 1; IGR-OV1; IGROV1; Igrov1; IGR.OV1; IGROV; OV1/P; OV1/p; OV1-P | 98.0 | % | Activity | C7979 | Orphanet_454723 |
| TKC135974 | SK-MEL-5 | SK-Mel-5; SK MEL 5; SK.MEL.5; SK-MEL5; SKMel-5; SKMEL-5; SKMEL5; SKMel5; SKmel5; AA-Mel | 97.0 | % | Activity | C3510 | |
| TKC135974 | SK-MEL-28 | SK-Mel-28; SK.MEL.28; SK-MEL 28; SK MEL-28; SK MEL 28; SK Mel 28; SKMel-28; SKMEL-28; SK-MEL28; SK-Mel28; SK Mel28; SKMEL28; SKMel28; SKmel28; SKML-28; SK28; AU-Mel; P-36; P36 | 119.0 | % | Activity | C3510 | |
| TKC135974 | SK-MEL-2 | SK-Mel-2; SK-Mel 2; SK-mel-2; SK-MEL2; SK.MEL.2; SK Mel 2; SK MEL 2; SKMEL-2; SKMEL2; SKmel2; SK-ML2; SKml2 | 147.0 | % | Activity | C3224 | |
| TKC135974 | MDA-MB-435 | MDA-MB435; MDAMB435; MDA.MB.435; MDA-435; MDA 435; MDA435; MD Anderson-Metastatic Breast-435 | 100.0 | % | Activity | C3802 | |
| TKC135974 | M14 | M14-MEL; UCLA-SO-M14; UCLA SO M14; UCLA-SO-14; UCLASO-M14; Melanoma 14; M-14 | 106.0 | % | Activity | C3802 | |
| TKC135974 | Malme-3M | MALME-3M; MALME 3M; Malme-3 M; MALME.3M; Malme3M; MALME3M; Malme-3 Monolayer | 115.0 | % | Activity | C3224 | |
| TKC135974 | LOX IMVI | LOX/IMVI; LOX IMVI; LOXIM-VI; LOXIMVI; LOX | 107.0 | % | Activity | C3802 | |
| TKC135974 | U-251 | U-251 MG; U-251-MG; U-251_MG; U251-MG; U251MG; U-251; U251; U251n; U251N; 251 MG; 251MG; 251 MG(6) | 103.0 | % | Activity | C60781 | Orphanet_94 |
| TKC135974 | SNB-75 | SNB.75; SNB75; Surgical Neurology Branch-75 | 94.0 | % | Activity | C3058 | Orphanet_360 |
| TKC135974 | SNB-19 | SNB.19; SNB19; Surgical Neurology Branch-19 | 98.0 | % | Activity | C60781 | Orphanet_94 |
| TKC135974 | SF-539 | SF-539; SF-539 BT; SF.539; SF 539 | 103.0 | % | Activity | C3796 | Orphanet_251576 |
| TKC135974 | SF-295 | SF-295; SF.295; SF 295 | 107.0 | % | Activity | C3058 | Orphanet_360 |
| TKC135974 | SW-620 | SW-620; SW 620; SW.620 | 114.0 | % | Activity | C4349 | |
| TKC135974 | KM12 | KM-12; KM.12 | 94.0 | % | Activity | C4910 | |
| TKC135974 | HCC 2998 | HCC-2998; HCC.2998; HCC 2998; Hamon Cancer Center 2998 | 100.0 | % | Activity | C4349 | |
| TKC135974 | COLO 205 | Colo 205; CoLo 205; COLO-205; Colo-205; COLO.205; Colo205; COLO205; Co 205; Colorado 205 | 117.0 | % | Activity | C4349 | |
| TKC135974 | NCI-H522 | NCI.H522; H522; H-522; NCI-522; NCI522; NCIH522 | 101.0 | % | Activity | C3512 | |
| TKC135974 | NCI-H460 | NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460 | 107.0 | % | Activity | C4450 | |
| TKC135974 | NCI-H322M | NCI.H322M; H322M; H-322M; H-322m | 113.0 | % | Activity | C2923 | |
| TKC135974 | NCI-H23 | NCI.H23; NCI H23; H-23; H23; NCIH23 | 95.0 | % | Activity | C3512 | |
| TKC135974 | NCI-H226 | NCI.H226; NCI H226; H226; H-226; HUT-226; HUT 226; NCIH226 | 107.0 | % | Activity | C45662 | Orphanet_50251 |
| TKC135974 | HOP-92 | HOP 92; HOP.92; HOP92; Hop92; Hopkins-92 | 85.0 | % | Activity | C2926 | |
| TKC135974 | HOP-62 | HOP 62; Hop 62; HOP.62; HOP62; Hop62; Hopkins-62 | 102.0 | % | Activity | C3512 | |
| TKC135974 | RPMI-8226 | RPMI 8226; RPMI.8226; RPMI8226; RPMI no. 8226; RPMI no 8226; RPMI #8226; 8226; RPMI 8226/S; RPMI-8226S; RPMI8226/S; 8226/S; Roswell Park Memorial Institute 8226; GM02132; GM2132; GM 2132; GM02132C; Simpson | 100.0 | % | Activity | C3242 | Orphanet_29073 |
| TKC135974 | MOLT-4 | Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D | 102.0 | % | Activity | C9142 | Orphanet_99861 |
| TKC135974 | K562 | K562; K.562; K 562; KO; GM05372; GM05372E | 93.0 | % | Activity | C9110 | Orphanet_521 |
| TKC135974 | CCRF-CEM | CCRF/CEM; CCRFCEM; CCRF.CEM; CCRF CEM; CCRF; CEM; CEM-CCRF; CEM-CCRF (CAMR); CCRF/CEM/0; CEM/0; CEM-0; CCRF-CEM/S; GM03671; GM03671C | 105.0 | % | Activity | C7953 | Orphanet_99861 |
| ID | Uniport | Pref_name | Gene name | value | unit | type |
|---|---|---|---|---|---|---|
| TKC135974 | P12931 | Proto-oncogene tyrosine-protein kinase Src | SRC | 35800 | nM | IC50 |
| Uniport ID | Uniport Name | ICD-11 |
|---|---|---|
| P12931 | SRC_HUMAN | Breast cancer [ICD-11: 2C60-2C6Y] |
| P12931 | SRC_HUMAN | Ischemia [ICD-11: 8B10-8B11] |
| P12931 | SRC_HUMAN | Multiple myeloma [ICD-11: 2A83] |
| P12931 | SRC_HUMAN | Myeloproliferative neoplasm [ICD-11: 2A20] |
| P12931 | SRC_HUMAN | Solid tumour/cancer [ICD-11: 2A00-2F9Z] |
| P12931 | SRC_HUMAN | Acute myeloid leukaemia [ICD-11: 2A60] |
| P12931 | SRC_HUMAN | BCR-ABL1-negative chronic myeloid leukaemia [ICD-11: 2A41] |
| P12931 | SRC_HUMAN | Brain cancer [ICD-11: 2A00] |
| P12931 | SRC_HUMAN | Cervical cancer [ICD-11: 2C77] |
| P12931 | SRC_HUMAN | Endometrial cancer [ICD-11: 2C76] |
| P12931 | SRC_HUMAN | Epidermal dysplasias [ICD-11: EK90] |
| P12931 | SRC_HUMAN | Fallopian tube cancer [ICD-11: 2C74] |
| P12931 | SRC_HUMAN | Gastrointestinal stromal tumour [ICD-11: 2B5B] |
| P12931 | SRC_HUMAN | Leiomyosarcoma [ICD-11: 2B58] |
| P12931 | SRC_HUMAN | Malignant digestive organ neoplasm [ICD-11: 2C11] |
| P12931 | SRC_HUMAN | Metastatic digestive system neoplasm [ICD-11: 2D8Y] |
| P12931 | SRC_HUMAN | Motor neuron disease [ICD-11: 8B60] |
| P12931 | SRC_HUMAN | Multiple sclerosis [ICD-11: 8A40] |
| P12931 | SRC_HUMAN | Ovarian cancer [ICD-11: 2C73] |
| P12931 | SRC_HUMAN | Pancreatic cancer [ICD-11: 2C10] |
| P12931 | SRC_HUMAN | Peritoneal cancer [ICD-11: 2C51] |
| P12931 | SRC_HUMAN | Sarcoma [ICD-11: 2A60-2C35] |
| P12931 | SRC_HUMAN | Synovial sarcoma [ICD-11: 2B5A] |
| P12931 | SRC_HUMAN | Malignant haematopoietic neoplasm [ICD-11: 2B33] |
| P12931 | SRC_HUMAN | Osteosarcoma [ICD-11: 2B51] |
| P12931 | SRC_HUMAN | Cardiovascular disease [ICD-11: BA00-BE2Z] |
| P12931 | SRC_HUMAN | Mature B-cell leukaemia [ICD-11: 2A82] |
| P12931 | SRC_HUMAN | Parkinsonism [ICD-11: 8A00] |
| P12931 | SRC_HUMAN | Postoperative inflammation [ICD-11: 1A00-CA43] |
| P12931 | SRC_HUMAN | Low bone mass disorder [ICD-11: FB83] |
| P12931 | SRC_HUMAN | Gram-positive bacterial infection [ICD-11: 1B74-1F40] |
| P12931 | SRC_HUMAN | Nasopharyngeal cancer [ICD-11: 2B6B] |