Basic Information

Terpenoid ID TKC134761
Cell line 11
Protein target 1
DiseaseNCIT 12
ORDO 4
ICD 15

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC134761 RAW264.7 RAW264 100.0 nM IC50 C21604
TKC134761 MCF7 10.0 ug.mL-1 IC50 C4194
TKC134761 K562 K562; K.562; K 562; KO; GM05372; GM05372E 17000.0 nM IC50 C9110 Orphanet_521
TKC134761 HeLa HELA; Hela; He La; He-La; HeLa-CCL2; Henrietta Lacks cells; Helacyton gartleri 6000.0 nM IC50 C27677
TKC134761 DU-145 DU-145; Du-145; DU 145; DU_145; DU.145; Duke University 145 3100.0 nM IC50 C4863
TKC134761 U-937 U937; U 937 2200.0 nM IC50 C8263 Orphanet_514
TKC134761 NCI-H1975 H1975; H-1975; NCIH1975 13000.0 nM IC50 C3512
TKC134761 A549 6200.0 nM IC50 C3512
TKC134761 MOLT-4 Molt-4; MOLT 4; Molt 4; MOLT.4; MOLT4; Molt4; GM02219; GM02219C; GM2219C; GM02219D 5500.0 nM IC50 C9142 Orphanet_99861
TKC134761 HL-60 HL 60; HL.60 HL60; Human Leukemia-60 2400.0 nM IC50 C9154 Orphanet_519
TKC134761 HCT-116 HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; CoCL2 4430.0 nM IC50 C4910
TKC134761 HT-29 HT 29; HT29 3370.0 nM IC50 C4349

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC134761 P40763 Signal transducer and activator of transcription 3 STAT3 48 % Inhibition

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P40763 STAT3_HUMAN Psoriasis [ICD-11: EA90]
P40763 STAT3_HUMAN Brain cancer [ICD-11: 2A00]
P40763 STAT3_HUMAN Colorectal cancer [ICD-11: 2B91]
P40763 STAT3_HUMAN Liver cancer [ICD-11: 2C12]
P40763 STAT3_HUMAN Malignant digestive organ neoplasm [ICD-11: 2C11]
P40763 STAT3_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
P40763 STAT3_HUMAN Pancreatic cancer [ICD-11: 2C10]
P40763 STAT3_HUMAN Respiratory infection [ICD-11: CA07-CA4Z]
P40763 STAT3_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P40763 STAT3_HUMAN Immune system disease [ICD-11: 4A01-4B41]
P40763 STAT3_HUMAN Postoperative inflammation [ICD-11: 1A00-CA43]
P40763 STAT3_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
P40763 STAT3_HUMAN Multiple myeloma [ICD-11: 2A83]
P40763 STAT3_HUMAN Mycosis fungoides [ICD-11: 2B01]
P40763 STAT3_HUMAN Ulcerative colitis [ICD-11: DD71]
P40763 STAT3_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]