Basic Information

Terpenoid ID TKC134744
Cell line 0
Protein target 21
DiseaseNCIT 0
ORDO 0
ICD 53

Active subnetwork


Terpenoid-cell-disease Activity Association

ID Cell Line Synonyms Value Unit Type NCIt ORDO
TKC134744 INS1 INS1 7821.0 nM AC50 C121566
TKC134744 HepG2 7943.0 nM Potency C3728 Orphanet_449
TKC134744 RAW264.7 RAW264 8200.0 nM IC50 C21604

Terpenoid-protein target Activity Association

ID Uniport Pref_name Gene name value unit type
TKC134744 P10636 Microtubule-associated protein tau MAPT 14125 nM Potency
TKC134744 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 TDP1 651 nM Potency
TKC134744 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 12995 nM Potency
TKC134744 P43220 Glucagon-like peptide 1 receptor GLP1R 10000 nM Potency
TKC134744 P84022 Mothers against decapentaplegic homolog 3 SMAD3 4467 nM Potency
TKC134744 Q03431 Parathyroid hormone/parathyroid hormone-related peptide receptor PTH1R 70795 nM Potency
TKC134744 Q16236 Nuclear factor erythroid 2-related factor 2 NFE2L2 20596 nM Potency
TKC134744 Q99700 Ataxin-2 ATXN2 7943 nM Potency
TKC134744 Q962Y6 Thioredoxin glutathione reductase TGR 35481 nM Potency
TKC134744 Q9UNA4 DNA polymerase iota POLI 17783 nM Potency
TKC134744 O75496 Geminin GMNN 1458 nM Potency
TKC134744 Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G 3162 nM Potency
TKC134744 O94782 Ubiquitin carboxyl-terminal hydrolase 1 USP1 35481 nM Potency
TKC134744 Q96QE3 ATPase family AAA domain-containing protein 5 ATAD5 3661 nM Potency
TKC134744 P51450 Nuclear receptor ROR-gamma Rorc 6310 nM Potency
TKC134744 P42858 Huntingtin HTT 5623 nM Potency
TKC134744 O15118 NPC intracellular cholesterol transporter 1 NPC1 3548 nM Potency
TKC134744 P51151 Ras-related protein Rab-9A RAB9A 2512 nM Potency
TKC134744 P17861 X-box-binding protein 1 XBP1 5710 nM IC50
TKC134744 P35639 DNA damage-inducible transcript 3 protein Ddit3 10000 nM IC50
TKC134744 P35639 DNA damage-inducible transcript 3 protein Ddit3 970 nM IC50
TKC134744 Q00987 E3 ubiquitin-protein ligase Mdm2 MDM2 590 nM EC50
TKC134744 O43521 Bcl-2-like protein 11 BCL2L11 >350000 nM EC50

Protein target-disease Activity Association

Uniport ID Uniport Name ICD-11
P10636 TAU_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
P10636 TAU_HUMAN Alzheimer disease [ICD-11: 8A20]
P10636 TAU_HUMAN Mild neurocognitive disorder [ICD-11: 6D71]
P10636 TAU_HUMAN Choreiform disorder [ICD-11: 8A01]
P10636 TAU_HUMAN Parkinsonism [ICD-11: 8A00]
P10636 TAU_HUMAN Central nervous system disease [ICD-11: 8A04-8D87]
P10636 TAU_HUMAN Neurodegenerative disorder [ICD-11: 8A20-8A23]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Liver cancer [ICD-11: 2C12]
O75874 IDHC_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
O75874 IDHC_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
O75874 IDHC_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P43220 GLP1R_HUMAN Cardiovascular disease [ICD-11: BA00-BE2Z]
P43220 GLP1R_HUMAN Obesity [ICD-11: 5B80-5B81]
P43220 GLP1R_HUMAN Type 2 diabetes mellitus [ICD-11: 5A11]
P43220 GLP1R_HUMAN Type-1/2 diabete [ICD-11: 5A10-5A11]
P43220 GLP1R_HUMAN Acute diabete complication [ICD-11: 5A2Y]
P43220 GLP1R_HUMAN Diabetes mellitus [ICD-11: 5A10]
P43220 GLP1R_HUMAN Dyspepsia [ICD-11: MD92]
P43220 GLP1R_HUMAN Irritable bowel syndrome [ICD-11: DD91]
P43220 GLP1R_HUMAN Intracranial injury [ICD-11: NA07]
P43220 GLP1R_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
P84022 SMAD3_HUMAN Herpes simplex infection [ICD-11: 1F00]
P84022 SMAD3_HUMAN Kidney fibrosis [ICD-11: GC01]
Q03431 PTH1R_HUMAN Low bone mass disorder [ICD-11: FB83]
Q03431 PTH1R_HUMAN Hypo-parathyroidism [ICD-11: 5A50]
Q16236 NF2L2_HUMAN Ataxic disorder [ICD-11: 8A03]
Q16236 NF2L2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q16236 NF2L2_HUMAN Glaucoma [ICD-11: 9C61]
Q16236 NF2L2_HUMAN Lung cancer [ICD-11: 2C25]
Q16236 NF2L2_HUMAN Macular degeneration [ICD-11: 9B75]
Q16236 NF2L2_HUMAN Melanoma [ICD-11: 2C30]
Q16236 NF2L2_HUMAN Mental/behavioural/neurodevelopmental disorder [ICD-11: 6E20-6E8Z]
Q16236 NF2L2_HUMAN Pulmonary hypertension [ICD-11: BB01]
Q16236 NF2L2_HUMAN Subarachnoid haemorrhage [ICD-11: 8B01]
Q16236 NF2L2_HUMAN Urinary system clinical sympton [ICD-11: MF8Y]
Q16236 NF2L2_HUMAN Non-alcoholic fatty liver disease [ICD-11: DB92]
Q16236 NF2L2_HUMAN Alpha-1-antitrypsin deficiency [ICD-11: 5C5A]
Q16236 NF2L2_HUMAN Motor neuron disease [ICD-11: 8B60]
Q16236 NF2L2_HUMAN Multiple sclerosis [ICD-11: 8A40]
O94782 UBP1_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
P42858 HD_HUMAN Choreiform disorder [ICD-11: 8A01]
P51151 RAB9A_HUMAN Fungal infection [ICD-11: 1F29-1F2F]
Q00987 MDM2_HUMAN Acute myeloid leukaemia [ICD-11: 2A60]
Q00987 MDM2_HUMAN Malignant haematopoietic neoplasm [ICD-11: 2B33]
Q00987 MDM2_HUMAN Myeloproliferative neoplasm [ICD-11: 2A20]
Q00987 MDM2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Q00987 MDM2_HUMAN Mature B-cell leukaemia [ICD-11: 2A82]
Q00987 MDM2_HUMAN Myelodysplastic syndrome [ICD-11: 2A37]
Q00987 MDM2_HUMAN Neuroendocrine carcinoma [ICD-11: 2C34]
Q00987 MDM2_HUMAN Liposarcoma [ICD-11: 2B59]
Q00987 MDM2_HUMAN Lung cancer [ICD-11: 2C25]
Q00987 MDM2_HUMAN Prostate cancer [ICD-11: 2C82]
Q00987 MDM2_HUMAN Breast cancer [ICD-11: 2C60-2C6Y]
Q00987 MDM2_HUMAN Solid tumour/cancer [ICD-11: 2A00-2F9Z]